In this paper, exponential synchronization for hybrid multi-weighted complex networks is studied via aperiodically intermittent control. Different from previous work, both Markov jump and reaction-diffusion effects are simultaneously considered into multi-weighted complex networks. By employing network split technique, graph theory, and Lyapunov method, several synchronization criteria are derived. These criteria show the effects of multiple weights, Markov jump, and reaction-diffusion on exponential synchronization. Furthermore, an application to Cohen-Grossberg neural networks is conducted, and the corresponding synchronization criterion is given. Finally, some numerical simulations are presented to show the effectiveness of the obtained theoretical results.