The impact of COVID-19 and masking practices on pertussis cases at a large academic medical center (2019-2021)

Sandoval, Tessa; Bisht, Anjali; Maurice, Annabelle de St

doi:10.1016/j.ajic.2022.11.012

Cited by 5 publications

(4 citation statements)

References 3 publications

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“…The COVID-19 pandemic restrictions, particularly masking and physical distancing measures, disrupted the usual patterns of distribution of common respiratory pathogens such as influenza and RSV [3], and negatively impacted vaccine coverage in many countries. Similarly, COVID-19 mitigation strategies led to a significant decrease in B. pertussis circulation, potentially compromising population immunity [4].…”

Section: Discussionmentioning

confidence: 99%

Pertussis outbreak in neonates and young infants across Italy, January to May 2024: implications for vaccination strategies

Poeta,

Moracas,

Albano

et al. 2024

Eurosurveillance

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Since January 2024, Italy experiences a pertussis outbreak, primarily affecting neonates and unvaccinated infants at high risk of severe complications and mortality; 11 major paediatric centres noted 108 hospitalisations and three deaths by 10 May. The outbreak reflects increased circulation of Bordetella pertussis and non-adherence to immunisation recommendations during pregnancy. Public health interventions, including maternal immunisation, vaccination of infants as early as possible and post-exposure prophylaxis, are critical for reducing the burden of pertussis and preventing further mortality.

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Section: Discussionmentioning

confidence: 99%

Pertussis outbreak in neonates and young infants across Italy, January to May 2024: implications for vaccination strategies

Poeta,

Moracas,

Albano

et al. 2024

Eurosurveillance

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“…Necroptosis and COVID-19 are closely related, as the innate immune recognition of SARS-CoV-2 by multiple host cell pattern recognition receptors induces the release of pro-inflammatory cytokines and inflammatory cell death, leading to acute respiratory distress syndrome, tissue injury, and cytokine storms ( Schifanella et al, 2023 ; Wiscovitch-Russo et al, 2023 ). The COVID-19 pandemic has significantly affected the spread of pertussis and the vaccination rates for pertussis-containing vaccines ( Sandoval et al, 2023 ). However, there is a risk of misdiagnosing pertussis infections due to the overlap of cough symptoms between COVID-19 and pertussis.…”

Section: Discussionmentioning

confidence: 99%

Deciphering the molecular nexus between Omicron infection and acute kidney injury: a bioinformatics approach

Wang,

Chen,

Zhang

et al. 2024

Front. Mol. Biosci.

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BackgroundThe ongoing global health crisis of COVID-19, and particularly the challenges posed by recurrent infections of the Omicron variant, have significantly strained healthcare systems worldwide. There is a growing body of evidence indicating an increased susceptibility to Omicron infection in patients suffering from Acute Kidney Injury (AKI). However, the intricate molecular interplay between AKI and Omicron variant of COVID-19 remains largely enigmatic.MethodsThis study employed a comprehensive analysis of human RNA sequencing (RNA-seq) and microarray datasets to identify differentially expressed genes (DEGs) associated with Omicron infection in the context of AKI. We engaged in functional enrichment assessments, an examination of Protein-Protein Interaction (PPI) networks, and advanced network analysis to elucidate the cellular signaling pathways involved, identify critical hub genes, and determine the relevant controlling transcription factors and microRNAs. Additionally, we explored protein-drug interactions to highlight potential pharmacological interventions.ResultsOur investigation revealed significant DEGs and cellular signaling pathways implicated in both Omicron infection and AKI. We identified pivotal hub genes, including EIF2AK2, PLSCR1, GBP1, TNFSF10, C1QB, and BST2, and their associated regulatory transcription factors and microRNAs. Notably, in the murine AKI model, there was a marked reduction in EIF2AK2 expression, in contrast to significant elevations in PLSCR1, C1QB, and BST2. EIF2AK2 exhibited an inverse relationship with the primary AKI mediator, Kim-1, whereas PLSCR1 and C1QB demonstrated strong positive correlations with it. Moreover, we identified potential therapeutic agents such as Suloctidil, Apocarotenal, 3′-Azido-3′-deoxythymidine, among others. Our findings also highlighted a correlation between the identified hub genes and diseases like myocardial ischemia, schizophrenia, and liver cirrhosis. To further validate the credibility of our data, we employed an independent validation dataset to verify the hub genes. Notably, the expression patterns of PLSCR1, GBP1, BST2, and C1QB were consistent with our research findings, reaffirming the reliability of our results.ConclusionOur bioinformatics analysis has provided initial insights into the shared genetic landscape between Omicron COVID-19 infections and AKI, identifying potential therapeutic targets and drugs. This preliminary investigation lays the foundation for further research, with the hope of contributing to the development of innovative treatment strategies for these complex medical conditions.

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“…Masking impacts not only COVID-19 transmission but also other respiratory diseases. 3 Although masks are supposed to be placed on a patient once measles is suspected, the patient has a potential for transmission to other patients as soon as the patient enters through the facility doors. Since the beginning of the COVID-19 pandemic, transmission risk has decreased with the usage of masks from the time any person enters a hospital facility.…”

Section: Discussionmentioning

confidence: 99%

“…2 Other studies have additionally found a direct correlation between masking mandates and a drop in pertussis cases. 3 …”

Section: Introductionmentioning

confidence: 99%

Respiratory infectious disease isolation During the COVID-19 pandemic

Deen

2023

American Journal of Infection Control

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The impact of COVID-19 and masking practices on pertussis cases at a large academic medical center (2019-2021)

Cited by 5 publications

References 3 publications

Pertussis outbreak in neonates and young infants across Italy, January to May 2024: implications for vaccination strategies

Pertussis outbreak in neonates and young infants across Italy, January to May 2024: implications for vaccination strategies

Deciphering the molecular nexus between Omicron infection and acute kidney injury: a bioinformatics approach

Respiratory infectious disease isolation During the COVID-19 pandemic

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