The impact of COVID-19 booster vaccination in the current pregnancy during the Omicron waves on maternal and perinatal outcomes: a multicentre observational study

Abstract

Material and Methods. This was an observational multicenter study. Pregnant women who gave birth while infected by SARS CoV2 during the Omicron waves were included. Patients were divided into 2 groups: the "booster vaccination" group included pregnant women who had completed vaccination and had received an additional dose of vaccine during pregnancy; the "non-booster vaccination" group included pregnant women who had completed primary vaccination without booster shots. Data about obstetrical and neonatal outcomes in both groups were compared.Results. In total, 59 patients were included: 41 received booster shots during the current pregnancy, and 18 did not. Asymptomatic forms were seen in 58.5% of the "booster vaccination" group versus 16.6% of the "non-boosted vaccination" group with p = 0.003. The need for cesarean delivery was reduced from 72.2% to 41.4% with p = 0.028. The length of hospitalization was reduced from 4.67 ± 4 days in the "non-boosted vaccination" group to 1.98 ± 0.93 days in the booster vaccination group with p = 0.001. The booster vaccination allowed reduced rates of prematurity with p = 0.011 and neonatal intensive care admissions with p = 0.007. Conclusions.The COVID-19 booster vaccination seems to be beneficial during the Omicron waves. It improved obstetrical and neonatal outcomes. So, pregnant women could be advised to get a booster dose of the COVID-19 vaccine when they get pregnant.

What does the cardiotocography say about SARS-CoV-2 infection? Cardiotocograph monitoring during the pandemic era: a narrative short review

“…The most important issue encountered, is related to the patients' selection: most of the studies reviewed, described CTG patterns of SARS-CoV-2-infected women without comparing them with an uninfected group. Another concern is that not all studies describe the SARS-CoV-2 variants involved, and we cannot determine whether different variants -for example, Omicron versus Delta -induce different CTG alterations [34,35]. Furthermore, not in all the studies, the COVID-19 symptomatology was sufficiently described, determined nor specified [36].…”

Association of inactivated COVID‐19 vaccination with maternal coagulation function in early pregnancy

“…Vaccination is the most effective way to decrease the severity of COVID‐19. It has been reported that vaccination during pregnancy improved obstetrical and neonatal outcomes by reducing the severity of COVID‐19 14–16 . However, reports of rare but severe thrombotic events characterized by blood clots and low platelet counts after receiving some COVID‐19 vaccines brought concerns about the safety of COVID‐19 vaccines 5–10 …”

“…It has been reported that vaccination during pregnancy improved obstetrical and neonatal outcomes by reducing the severity of COVID-19. [14][15][16] However, reports of rare but severe thrombotic events characterized by blood clots and low platelet counts after receiving some COVID-19 vaccines brought concerns about the safety of COVID-19 vaccines. [5][6][7][8][9][10] In this study, we first examined whether vaccination with inactivated COVID-19 vaccine before conception was associated with coagulation changes in pregnant women.…”