The impact of COVID-19 on the pediatric solid organ transplant population

Feldman, Amy G.; Danziger‐Isakov, Lara

doi:10.1016/j.sempedsurg.2022.151178

Cited by 9 publications

(7 citation statements)

References 47 publications

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“…Asthma, a comorbidity with high incidence in Mexico, is also associated with poor prognosis and mortality when compared with other patients with COVID-19 [ 33 ], in whom immunosuppression and diabetes were other comorbidities identified with high incidence. Patients with immunosuppression and malignancy and recipients of solid-organ transplantation have been associated with an increased risk of severe COVID-19 and death, in addition to type 1 and type 2 diabetes [ 34 , 35 , 36 ]. In the HIMFG, immunosuppression, cardiovascular disease, obesity, and asthma had the highest incidence in patients with COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Coronavirus Disease (COVID-19) in Mexican Children and Adolescents

Flores-Alanis

Saldaña-Ahuactzi

Parra-Ortega

et al. 2022

Viruses

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Background: We analyzed the demographic, clinical, and diagnostic data of children and adolescents in Mexico, from the first case of coronavirus disease (COVID-19) to 28 February 2022. Methods: Using the open databases of the Ministry of Health and a tertiary pediatric hospital, we obtained demographic and clinical data from the beginning of the COVID-19 pandemic until 28 February 2022. In addition, quantitative reverse-transcription polymerase chain reaction outputs were used to determine the viral load, and structural protein-based serology was performed to evaluate IgG antibody levels. Results: Of the total 437,832 children and adolescents with COVID-19, 1187 died. Of these patients, 1349 were admitted to the Hospital Infantil de Mexico Federico Gómez, and 11 died. Obesity, asthma, and immunosuppression were the main comorbidities, and fever, cough, and headache were the main symptoms. In this population, many patients have a low viral load and IgG antibody levels. Conclusion: During the first 2 years of the COVID-19 pandemic in Mexico, children and adolescents had low incidence and mortality. They are a heterogeneous population, but many patients had comorbidities such as obesity, asthma, and immunosuppression; symptoms such as fever, cough, and headache; and low viral load and IgG antibodies.

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Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Coronavirus Disease (COVID-19) in Mexican Children and Adolescents

Flores-Alanis

Saldaña-Ahuactzi

Parra-Ortega

et al. 2022

Viruses

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“…Additionally, the rates of pediatric infection and hospitalizations have recently increased exponentially with the circulation of the SARS‐CoV‐2 Delta (B.1.617.2), Omicron, and other variants 54,56,57 . Second, data suggest that the antibody response to a 2‐dose COVID‐19 vaccine series is dampened in solid organ transplant recipients 17,19,21,22,58 . Therefore, it is optimal for transplant patients to receive COVID‐19 vaccine before transplant and before they start on immunosuppressive medications.…”

Section: Discussionmentioning

confidence: 99%

“…54,56,57 Second, data suggest that the antibody response to a 2dose COVID-19 vaccine series is dampened in solid organ transplant recipients. 17,19,21,22,58 Therefore, it is optimal for transplant patients to receive COVID-19 vaccine before transplant and before they start on immunosuppressive medications.…”

Section: Ta B L E 3 Covid-19 Vaccine Mandatesmentioning

confidence: 99%

Survey of pediatric transplant center practices regarding COVID‐19 vaccine mandates for transplant candidates and living donors and use of COVID‐19‐positive deceased organs

Feldman

Beaty

Everitt

et al. 2023

Pediatric Transplantation

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BackgroundCOVID‐19 vaccine is recommended for individuals ages ≥6 months; however, whether vaccination should be mandated for transplant candidates and living donors remains controversial. This study assessed COVID‐19 policies at US pediatric solid organ transplant centers.MethodsA 79‐item survey was emailed between March and April 2022 to 200 UNOS Medical Directors detailing center COVID‐19 vaccine policies for transplant candidates and living donors and use of grafts from COVID‐19‐positive deceased donors.ResultsThe response rate was 77% (154/200). For children aged 5–15 years, 23% (35/154 centers) have a COVID‐19 vaccine mandate, 27% (42/154) anticipate implementing a future mandate, and 47% (72/154) have not considered or do not anticipate implementing a mandate. For children ≥16 years, 32% (50/154 centers) have a COVID‐19 vaccine mandate, 25% (39/154) anticipate implementing a future mandate, and 40% (62/154) have not considered or do not anticipate implementing a mandate. The top two reasons for not implementing a COVID‐19 vaccine mandate were concerns about penalizing a child for their parent's decision and worsening inequities in transplant. Of 85 kidney and liver living donor centers, 32% (27/85) require vaccination of donors. Twenty percent (31/154) of centers accept organs from COVID‐19‐positive deceased donors.ConclusionsThere is great variation among pediatric SOT centers in both the implementation and details of COVID‐19 vaccine mandates for candidates and living donors. To guide more uniform policies, further data are needed on COVID‐19 disease, vaccine efficacy, and use of grafts from donors positive for COVID‐19 in the pediatric transplant population.

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“…As of yet, there are limited published data describing the outcomes of immunocompromised children infected with SARS‐CoV‐2. 39 , 40 , 41 , 42 In adults, the risk of the worst COVID‐19 evolution has frequently led to the postponement of anticancer therapies. 42 , 43 However, in childhood, most cancers require intensive treatment, which, if postponed, may be life‐threatening.…”

Section: Focus On Atypical Respiratory Manifestations Of Covid‐19 In ...mentioning

confidence: 99%

“…As of yet, there are limited published data describing the outcomes of immunocompromised children infected with SARS‐CoV‐2 39–42 . In adults, the risk of the worst COVID‐19 evolution has frequently led to the postponement of anticancer therapies 42,43 .…”

Section: Focus On Atypical Respiratory Manifestations Of Covid‐19 In ...mentioning

confidence: 99%

COVID‐19 and pediatric pulmonology: Feedback from an expert center after the first year of the pandemic

Corvol

Prévost

Aubertin

et al. 2022

Pediatric Pulmonology

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The coronavirus disease 2019 (COVID‐19) outbreak has evolved with different waves corresponding to subsequent severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) mutations. While the most severe cases have been observed in the elderly and in individuals with underlying comorbidities, severe pediatric and young adult cases have been observed, as well as post‐infectious inflammatory syndromes and persistent symptoms leading to long‐COVID. This manuscript describes the experience of a pediatric respiratory unit during the first year of the pandemic and reviews the corresponding literature with a special emphasis on children and young people with underlying conditions, such as immunosuppression, sickle cell disease, and cystic fibrosis.

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The impact of COVID-19 on the pediatric solid organ transplant population

Cited by 9 publications

References 47 publications

Clinical Characteristics of Coronavirus Disease (COVID-19) in Mexican Children and Adolescents

Clinical Characteristics of Coronavirus Disease (COVID-19) in Mexican Children and Adolescents

Survey of pediatric transplant center practices regarding COVID‐19 vaccine mandates for transplant candidates and living donors and use of COVID‐19‐positive deceased organs

COVID‐19 and pediatric pulmonology: Feedback from an expert center after the first year of the pandemic

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