The Impact of COVID-19 Pandemic Lockdown on the Relationship between Pediatric MAFLD and Renal Function

Valentino, Maria Sole; Marzuillo, Pierluigi; Esposito, Claudia; Bartiromo, Mario; Nardolillo, Michele; Villani, Annalisa Valentina; Maresca, Alessandro; Furcolo, Giuseppe; Guarino, Stefano; Giudice, E Miraglia Del; Sessa, Anna Di

doi:10.3390/jcm12052037

Cited by 3 publications

(2 citation statements)

References 57 publications

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“…Current evidence points towards an association between severe COVID-19 outcomes and factors such as older age [ 4 , 5 , 6 , 7 ], male gender [ 4 , 6 , 7 ], and multiple comorbidities including hypertension [ 8 , 9 ], cardiovascular disease [ 7 ], obesity [ 4 , 5 , 10 , 11 ], and type 2 diabetes [ 7 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

The Intersection of COVID-19 and Metabolic-Associated Fatty Liver Disease: An Overview of the Current Evidence

Buchynskyi

Kamyshna

Oksenych

et al. 2023

Viruses

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The global population is currently experiencing the impact of the SARS-CoV-2 coronavirus, which has caused the Coronavirus Disease 2019 (COVID-19) pandemic. With our profound comprehension of COVID-19, encompassing the involvement sequence of the respiratory tract, gastrointestinal system, and cardiovascular apparatus, the multiorgan symptoms of this infectious disease have been discerned. Metabolic-associated fatty liver disease (MAFLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a pervasive public health concern intricately linked with metabolic dysregulation and estimated to afflict one-fourth of the global adult population. The burgeoning focus on the association between COVID-19 and MAFLD is justified by the potential role of the latter as a risk factor for both SARS-CoV-2 infection and the subsequent emergence of severe COVID-19 symptoms. Investigations have suggested that changes in both innate and adaptive immune responses among MAFLD patients may play a role in determining the severity of COVID-19. The remarkable similarities observed in the cytokine pathways implicated in both diseases imply the existence of shared mechanisms governing the chronic inflammatory responses characterizing these conditions. The effect of MAFLD on the severity of COVID-19 illness remains uncertain, as indicated by conflicting results in cohort investigations.

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Section: Introductionmentioning

confidence: 99%

The Intersection of COVID-19 and Metabolic-Associated Fatty Liver Disease: An Overview of the Current Evidence

Buchynskyi

Kamyshna

Oksenych

et al. 2023

Viruses

View full text Add to dashboard Cite

show abstract

“…However, it has become evident that the outcome of infection is heavily influenced by host-related factors, including advanced age [ 2 , 3 , 4 , 5 ], male gender [ 2 , 4 , 5 ], and the presence of various comorbidities such as hypertension [ 6 , 7 ], cardiovascular disease [ 5 ], obesity [ 2 , 3 , 8 , 9 ], and type 2 diabetes [ 5 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis

Buchynskyi

Oksenych

Kamyshna

et al. 2023

Viruses

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Metabolic-associated fatty liver disease (MAFLD) and its potential impact on the severity of COVID-19 have gained significant attention during the pandemic. This review aimed to explore the genetic determinants associated with MAFLD, previously recognized as non-alcoholic fatty liver disease (NAFLD), and their potential influence on COVID-19 outcomes. Various genetic polymorphisms, including PNPLA3 (rs738409), GCKR (rs780094), TM6SF2 (rs58542926), and LYPLAL1 (rs12137855), have been investigated in relation to MAFLD susceptibility and progression. Genome-wide association studies and meta-analyses have revealed associations between these genetic variants and MAFLD risk, as well as their effects on lipid metabolism, glucose regulation, and liver function. Furthermore, emerging evidence suggests a possible connection between these MAFLD-associated polymorphisms and the severity of COVID-19. Studies exploring the association between indicated genetic variants and COVID-19 outcomes have shown conflicting results. Some studies observed a potential protective effect of certain variants against severe COVID-19, while others reported no significant associations. This review highlights the importance of understanding the genetic determinants of MAFLD and its potential implications for COVID-19 outcomes. Further research is needed to elucidate the precise mechanisms linking these genetic variants to disease severity and to develop gene profiling tools for the early prediction of COVID-19 outcomes. If confirmed as determinants of disease severity, these genetic polymorphisms could aid in the identification of high-risk individuals and in improving the management of COVID-19.

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Interplay between metabolic dysfunction-associated fatty liver disease and renal function: An intriguing pediatric perspective

Nardolillo,

Rescigno,

Bartiromo

et al. 2024

World J Gastroenterol

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Over recent years, the nomenclature of non-alcoholic fatty liver disease has undergone significant changes. Indeed, in 2020, an expert consensus panel proposed the term “Metabolic (dysfunction) associated fatty liver disease” (MAFLD) to underscore the close association of fatty liver with metabolic abnormalities, thereby highlighting the cardiometabolic risks (such as metabolic syndrome, type 2 diabetes, insulin resistance, and cardiovascular disease) faced by these patients since childhood. More recently, this term has been further replaced with metabolic associated steatotic liver disease. It is worth noting that emerging evidence not only supports a close and independent association of MAFLD with chronic kidney disease in adults but also indicates its interplay with metabolic impairments. However, comparable pediatric data remain limited. Given the progressive and chronic nature of both diseases and their prognostic cardiometabolic implications, this editorial aims to provide a pediatric perspective on the intriguing relationship between MAFLD and renal function in childhood.

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The Impact of COVID-19 Pandemic Lockdown on the Relationship between Pediatric MAFLD and Renal Function

Cited by 3 publications

References 57 publications

The Intersection of COVID-19 and Metabolic-Associated Fatty Liver Disease: An Overview of the Current Evidence

The Intersection of COVID-19 and Metabolic-Associated Fatty Liver Disease: An Overview of the Current Evidence

Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis

Interplay between metabolic dysfunction-associated fatty liver disease and renal function: An intriguing pediatric perspective

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