The Impact of Curcumin on Immune Response: An Immunomodulatory Strategy to Treat Sepsis

Allegra, Alessandro; Mirabile, Giuseppe; Ettari, Roberta; Pioggia, Giovanni; Gangemi, Sebastiano

doi:10.3390/ijms232314710

Cited by 7 publications

(2 citation statements)

References 161 publications

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“…The antioxidant activity of curcumin helps protect immune cells from oxidative damage and supports proper functioning. Research suggests curcumin positively influences immune health by promoting a balanced immune response and contributing to human disease control and prevention [11].…”

Section: Curcuminmentioning

confidence: 99%

The Immunological Significance of Medicinal Plants in Disease Control and Prevention in Humans

Alajeeli,

Al-Karawi,

Ali

2023

AJMS

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This abstract provides a review highlighting the significant role of medicinal plants in the treatment of various diseases globally. To explore this, a questionnaire was conducted in Baghdad to inquire whether individuals resorted to using medicinal plants when experiencing illness. The objective was to gain insights into the efficacy of medicinal plants when used as a form of treatment. Findings from studies conducted worldwide consistently indicate that medicinal plants are widely utilized due to their positive outcomes and cost-effectiveness compared to chemical drugs. Furthermore, ongoing research on the effects of medicinal plants has resulted in the development of novel therapies for numerous chronic ailments, including Parkinson’s disease, diabetes, hypertension, peptic ulcers, IBS syndrome, and other acute and chronic conditions.

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Section: Curcuminmentioning

confidence: 99%

The Immunological Significance of Medicinal Plants in Disease Control and Prevention in Humans

Alajeeli,

Al-Karawi,

Ali

2023

AJMS

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“…Therefore, modification of the immune state of macrophages should be one of the primary considerations in the treatment of sepsis. Curcumin was a bioactive molecular with macrophage modification ability in sepsis [9,10]. However, insolubility and poor bioavailability limited the clinical application of curcumin [11,12].…”

Section: Introductionmentioning

confidence: 99%

Efferocytosis-inspired nanodrug treats sepsis by alleviating inflammation and secondary immunosuppression

Guo,

Shen,

Shao

et al. 2023

Biomed. Mater.

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Uncontrolled inflammation storm induced by sepsis may lead to severe organ dysfunction and secondary immunosuppression, which is one of the main reasons for high mortality and prolonged hospitalization of septic patients. However, there is a lack of effective treatments for it at present. Here, we report an efferocytosis-inspired nanodrug (BCN@M) to treat sepsis and secondary immunosuppression via regulating the macrophage function. Bioactive molecular curcumin was loaded with bovine serum albumin (BSA) and then coated with the damaged erythrocyte membrane derived from septic mice. It was found that the septic erythrocytes promoted the efferocytosis signal and BCN@M uptake efficiency by macrophages. The well-constructed BCN@M nanodrug reduced the hyperinflammation in sepsis and restored the bacterial clearance ability of macrophage in the secondary immunosuppression state. This study highlights BCN@M as an efferocytosis-inspired nanodrug to alleviate hyperinflammation and secondary immunosuppression of sepsis.

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The Use of Herbal Medicine and Dietary Supplements in Cancer Patients Receiving Immune Checkpoint Inhibitors: A Multicenter Cross-Sectional Study

Kus,

Can Guven,

Yildirim

et al. 2024

Integr Cancer Ther

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Aims: This study aimed to assess the habits and knowledge of cancer patients regarding the use of herbal medicines and dietary supplements in cancer patients receiving immune checkpoint inhibitors (ICI). Methods: The data of 181 cancer patients who were over 18 years old and received ICIs were collected. The usage patterns, anticipated benefits and harms, and sources of supply were evaluated by filling researcher-prepared forms. Results: Most patients did not use any kind of herbal medicine (91.2%) or dietary supplements (75.9%) during their immunotherapy. Boosting the immune system is the primary motivation for use among users. Multivitamins are the most frequently used supplements. Family members and TV advertisements were the main sources of information, in addition to limited advice from healthcare professionals. A minority of participants reported gastrointestinal side effects. Herbal medicine and dietary supplement use were more prevalent among patients with stage IV cancer and renal cell carcinoma (RCC). Discussion: This study revealed that the limited uptake of herbal medicines and dietary supplements alongside ICI treatment among cancer patients. The lack of adequate information from healthcare professionals poses potential risks to patients. Improved communication with patients, education regarding herbal medicine and dietary supplement use, potential interactions, and associated risks during ICI treatment are essential. Further research is needed to identify the specific needs of patients, anticipated benefits, and potential harms of herbal medicine and dietary supplement use, together with ICIs.

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The Impact of Curcumin on Immune Response: An Immunomodulatory Strategy to Treat Sepsis

Cited by 7 publications

References 161 publications

The Immunological Significance of Medicinal Plants in Disease Control and Prevention in Humans

The Immunological Significance of Medicinal Plants in Disease Control and Prevention in Humans

Efferocytosis-inspired nanodrug treats sepsis by alleviating inflammation and secondary immunosuppression

The Use of Herbal Medicine and Dietary Supplements in Cancer Patients Receiving Immune Checkpoint Inhibitors: A Multicenter Cross-Sectional Study

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