2009
DOI: 10.1002/cncr.24501
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The impact of cytomorphology, cytogenetics, molecular genetics, and immunophenotyping in a comprehensive diagnostic workup of myelodysplastic syndromes

Abstract: These supportive care recommendations were prepared to guide doctors who practice in areas with significantly limited resources but who have sufficient infrastructure and training to treat children with cancer with curative intent. The success of any cancer treatment regimen depends largely on the availability and quality of supportive care and this also determines the intensity of treatment that can be delivered. We present practical recommendations on how to prevent infections, general nursing care, manageme… Show more

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Cited by 22 publications
(12 citation statements)
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“…Interestingly, both patients who gained a chromosome 13 (UPNs 1 and 22) had antecedent mutations in RUNX1. According to current literature, RUNX1 mutations occur at a frequency of about 15% in MDS, 7 thus the rate of RUNX1 mutations is increased in our patient cohort, which is defined by leukemic evolution. Thus, our results suggest that the detection of RUNX1 mutations in MDS comes along with a propensity to leukemic transformation.…”
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confidence: 63%
“…Interestingly, both patients who gained a chromosome 13 (UPNs 1 and 22) had antecedent mutations in RUNX1. According to current literature, RUNX1 mutations occur at a frequency of about 15% in MDS, 7 thus the rate of RUNX1 mutations is increased in our patient cohort, which is defined by leukemic evolution. Thus, our results suggest that the detection of RUNX1 mutations in MDS comes along with a propensity to leukemic transformation.…”
mentioning
confidence: 63%
“…In a recent study reported, MLL PTD was found in 8 of 163 (5%) of RAEB cases, and 2 of 210 (1%) low-grade MDS cases; however, the karyotype information of these cases was not revealed. 31 It is important to recognize that MLL PTDs are highly variable and that Southern blot analysis with the currently available probes may not detect all PTDs. This is also true for the currently used nested reverse transcription-PCR using two primer sets.…”
Section: Discussionmentioning
confidence: 99%
“…The method is increasingly used for diagnosing MDS and is also established as co-criterion in newer recommendations for diagnostic workup (5,(12)(13)(14)(15). The value of MFC for making the diagnosis MDS and even in detecting prognostic factors for this disease has been demonstrated in a number of studies (16)(17)(18)(19). Different ''flow scores'' have been introduced for MFC in MDS (20)(21)(22).…”
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confidence: 99%