Background: Uptake of treatment for hepatitis C virus (HCV) is low in Canada despite its publicly funded health care system. We explored the uptake of HCV treatment within the Canadian Co-infection Cohort to determine if some treatment centres have been more successful than others at starting patients with HIV-HCV coinfection on HCV treatment.
Methods:We estimated the variation between 16 centres in the uptake of HCV treatment using a Weibull time-to-event model with adjustment for patient characteristics that are thought likely to influence the uptake of treatment. We asked the principal investigator at each centre about access to hepatitis-related specialists and services and the importance of various criteria when determining if a patient with HIV-HCV coinfection should receive treatment for HCV.
Results:Among 681 untreated patients in the Canadian Co-infection Cohort, 163 patients with HIV-HCV coinfection started HCV treatment over a period of 1827 patient-years (9 per 100 patient-years). Even after adjustment for case mix, there was still appreciable variation in treatment uptake between centres, with mean hazard ratios of 0.43 (95% credible interval 0.11-1.3) and 3.6 (95% credible interval 1.7-8.4) for the centres least and most likely to start an average patient with HIV-HCV coinfection on HCV treatment. The most important criteria reported by principal investigators for determining eligibility for treatment were severity of fibrosis, current psychiatric comorbidities, current alcohol intake, past HCV treatment and a history of reinfection with HCV. However, the opinions were wide-ranging: 8 of the 15 criteria elicited both the responses "less important" and "very important."
Interpretation:The magnitude of the centre effects and diverse opinions about the importance of treatment eligibility criteria suggest that provider-related barriers to HCV treatment uptake are as important as patient-related barriers.
AbstractCMAJ OPEN, 1(3)
E107
Research
CMAJ OPENare infected with HCV. 11,12 In a recent survey, 80% of Canadian physicians who specialize in HCV said that they were not likely to provide HCV treatment to active injection drug users. 13 Injection drug users are often considered ineligible for treatment because of poor adherence to care, psychiatric illness or ongoing use of drugs or alcohol. 14,15 Even if eligible, patients with HCV may be reluctant to start treatment. 16 In the United States, patients are less likely to be offered and to accept HCV treatment if they are older, male, not white, infected with a difficult-to-treat HCV genotype, have psychiatric illness, or if they use drugs or alcohol. [17][18][19] Many studies have evaluated these patient-related barriers to treatment, 20,21 which are difficult to overcome. Provider and institutional barriers are also important; 17,22 these are perhaps more amenable to intervention. Although having access to an experienced provider is clearly important for the uptake of HCV treatment, [17][18][19] it is not clear what other provider and institutional bar...