The Impact of Deep Brain Stimulation on the Sexual Function of Patients With Parkinson’s Disease

Pedro, Tiago; Sousa, Mário; Rito, Manuel; Pereira, Ricardo; Januário, Cristina; Moreira, Fradique

doi:10.1097/nrl.0000000000000272

Cited by 12 publications

(17 citation statements)

References 46 publications

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“…Although the results of both instruments showed a moderate correlation between them and with depression, self-esteem, and CRQ, the SQ-F was correlated with a larger number of factors than FSFI, including cognition and severity of NMS. Furthermore, the results from multiple regression models confirmed that FSFI and SQ-F scores could be predicted by different factors: while depression severity was the unique able to predict the FSFI, the global cognitive capacity and that CRQ were the best predictors for the SQ-F. Based on this evidence, although most previous studies investigating SH in WwPD had used FSFI [12,16,20,27,30,36,43], the addition of an evaluation over a longer term by SQ-F may offer a more comprehensive disease impact on SH..…”

Section: Discussionmentioning

confidence: 56%

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Sexual health in women with Parkinson’s disease: Motor, non-motor, and social impacts

Nobrega,

da Silva Nascimento,

Souza

et al. 2023

Preprint

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Background: Sexual dysfunction (SD) is a common non-motor symptom (NMS) in people with Parkinson disease (PwPD). Sexual health (SH) depends on several biological, mental, and social factors that PD may affect. Despite its prevalence and relevance for quality of life, SD in women with Parkinson disease (WwPD) is poorly understood, and research in this area is scarce. Objectives: To investigate the impact of motor, non-motor, and social aspects on the SH of WwPD. Methods: We conducted a cross-sectional study of 100 women (mean age 54.45 sd 8.31, mean H&Y stage 1.70 sd 0.71). The following data were collected for each person (used tests/scales indicated within parentheses and defined in Glossary): (1) demographic information and global cognitive capacity (T-MoCA); (2) non-motor aspects of daily life experiences (MDS-UPDRS, part I); (3) motor aspects of daily life experiences (MDS-UPDRS, part II); (4) fatigue (FSS); (5) self-esteem (RSES); (6) sleep disorder (PDSS); (7) couple relationship quality (CRQ) (DAS); (8) depressive signals (BDI); (8) short-term sexual health (FSFI); and (9) long-term sexual health (SQ-F). Results: Our results suggest that depressive symptoms, preserved cognitive status, and CRQ are predictive factors in the sexual health of WwPD. Age, disease onset, duration, postmenopausal, Levodopa dosage, motor disability, and fatigue were not correlated with SH. Conclusion: Our findings emphasize the need to assess the sexual functioning of WwPD to investigate which motor, non-motor, and social aspects may be involved in SD so that measures can be implemented in clinical practice.

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Section: Discussionmentioning

confidence: 56%

“…In the absence of any illness, the aging process plays a key role in the development of SD [11]. Age is an independent predictive factor for developing erectile dysfunction in men and SD in women [12]. However, the aging effect on SH in PD is a complex issue and several studies showed that SD and sexual satisfaction in PD worsened with aging [13,14,15,16].…”

mentioning

confidence: 99%

Sexual health in women with Parkinson’s disease: Motor, non-motor, and social impacts

Nobrega,

da Silva Nascimento,

Souza

et al. 2023

Preprint

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“…Our multiple regression models revealed that different factors predicted scores on each instrument, with quality of marital relationship predicting general short-term SH (IIFE total score), motor disability predicting EF domain, and depression predicting SQ-M. Although the majority previous studies have used IIEF, primarily EF domain, [11,14,20,36,39] to evaluate SF in MwPD, our findings suggest that incorporating the SQ-M questionnaire can provide additional insight into how the PD affects SH.…”

Section: Discussionmentioning

confidence: 93%

“…The ranges of scores allow classifying erectile dysfunction (ED) into five categories, based on the domain of erectile function, with scores ranging from 6 to 30: without ED (26-30); mild ED (22)(23)(24)(25); mild to moderate ED (17)(18)(19)(20)(21); moderate ED (11)(12)(13)(14)(15)(16); severe ED (6)(7)(8)(9)(10).…”

Section: International Index Of Erectile Function (Iief) -Short-term Shmentioning

confidence: 99%

The impact of motor, non-motor, and social aspects on the sexual health of men living with Parkinson’s disease

Antunes Souza,

Costa Nóbrega,

de Almeida da Silva

et al. 2023

Preprint

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Background: Sexual health (SH) is influenced by several biological, mental, and social factors which may be negatively impacted by PD. Despite its prevalence and relevance for quality of life, the factors that affect the SH in men with Parkinson's disease (MwPD) are still poorly understood, and research in this area is scarce. Aim: To investigate the impact of motor, non-motor, and social aspects on the SH in MwPD. Method: We conducted a cross-sectional study of 80 men (mean age 53.55+/-10.8) in stages 1-3 of disease progression according to Hoehn and Yahr classification (H&Y), who reported to have sexual activity. The following data were collected for each person (used tests/scales indicated within parentheses and defined in glossary): (1) demographic information and global cognitive capacity (T-MoCA); (2) non-motor aspects of daily life experiences (MDS-UPDRS, part I); (3) motor aspects of daily life experiences (MDS-UPDRS, part II); (4) fatigue (FSS); (5) self-esteem (RSES); (6) sleep disorder (PDSS); (7) couple relationship quality (DAS); (8) depressive signals (BDI); (8) short-term sexual health by International Index of Erectile Function (IIFE); and (9) long-term sexual health by Sexual Quotient-Male (SQ-M). Results: Our results suggest that the quality of marital relationships predicts short-term SH, motor disability level predicts erectile dysfunction, and depression predicts long-term SH in MwPD. Age, disease onset, disease duration, Levodopa dosage, and non-motor symptoms, excluding depression, were not correlated with SH. Conclusion: Our findings confirm that multidimensional factors can affect the SH of MwPD and emphasize that only a multi-professional team can offer proper care to improve SH in MwPD.

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“…DBS-STN has no direct effect on the PD patients’ sexual life. Emotional well-being may contribute to a different opinion of the sexual function according to the patient’s sex [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Subthalamic nucleus-deep brain stimulation improves autonomic dysfunctions in Parkinson’s disease

Zhang

Wang

et al. 2022

BMC Neurol

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Background To study the effects of subthalamic nucleus-deep brain stimulation (STN-DBS) on autonomic dysfunctions in Parkinson’s disease (PD) patients. Methods A total of 57 PD patients who underwent bilateral STN-DBS from March to December 2018, were retrospectively analyzed. Preplanned assessments at baseline and postoperatively at 1, 3, and 6 months also included the Scales for Outcomes in Parkinson’s Disease-Autonomic questionnaire (SCOPA-Aut), the Unified Parkinson’s Disease Rating Scale (UPDRS) III score, levodopa equivalent day dose (LEDD), Parkinson’s Disease Quality of Life Scale (PDQ-39), the Hamilton Anxiety Rating Scale (HAMA), and the Hamilton Depression Rating Scale (HAMD). Results The SCOPA-Aut scores improved significantly [14.59% (18.32%), 24.00% (27.05%), 22.16% (27.07%), all P < 0.001] at 1 month, 3 months, and 6 months of STN-DBS, respectively. Analysis of the SCOPA-Aut sub-items showed significant improvements only in urine and thermoregulation sub-items at 6 months after surgery (P < 0.001). There was no significant correlation between improvements of SCOPA-Aut scores and improvements of PDQ-39 scores (P > 0.05) at 6 months after surgery. SCOPA-Aut scores were positively correlated with age (r = 0.428, P = 0.001); the improvements of SCCOPA-Aut scores were positively correlated with improvements of HAMA and HAMD scores (HAMA: r = 0.325, P = 0.015; HAMD: r = 0.265, P = 0.049) at 6 months after surgery. Conclusion STN-DBS improved autonomic dysfunction symptoms of PD patients, and urinary and thermoregulatory sub-items of autonomic dysfunction were improved in the short-term after surgery. There was a close relationship between improved autonomic symptoms and improved anxiety and depression 6 months after surgery. We should therefore direct more attention to autonomic dysfunctions in PD involving detailed preoperative evaluations and postoperative follow-ups, to improve the quality of life of patients.

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The Impact of Deep Brain Stimulation on the Sexual Function of Patients With Parkinson’s Disease

Cited by 12 publications

References 46 publications

Sexual health in women with Parkinson’s disease: Motor, non-motor, and social impacts

Sexual health in women with Parkinson’s disease: Motor, non-motor, and social impacts

The impact of motor, non-motor, and social aspects on the sexual health of men living with Parkinson’s disease

Subthalamic nucleus-deep brain stimulation improves autonomic dysfunctions in Parkinson’s disease

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