The impact of developmental genes in non-syndromic cleft lip and/or palate

Uysal, Nihal Şahin; Şahin, Feride İffet; Terzi, Yunus Kasım

doi:10.4274/jtgga.galenos.2022.2021-10-7

Cited by 8 publications

(1 citation statement)

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“…Organ development involves interactions among genes that regulate cell growth, proliferation, differentiation, epithelial-to-mesenchymal transition, and apoptosis ( Şahin Uysal et al, 2023 ). For example, the skeletal system provides a structural framework for muscle attachment and is crucial for supporting movement, protecting organs, and maintaining vascular homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Genetic mechanism of body size variation in groupers: Insights from phylotranscriptomics

Zhang,

Weng,

Wang

et al. 2024

Zoological Research

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Animal body size variation is of particular interest in evolutionary biology, but the genetic basis remains largely unknown. Previous studies have shown the presence of two parallel evolutionary genetic clusters within the fish genus Epinephelus with evident divergence in body size, providing an excellent opportunity to investigate the genetic basis of body size variation in vertebrates. Herein, we performed phylotranscriptomic analysis and reconstructed the phylogeny of 13 epinephelids originating from the South China Sea. Two genetic clades with an estimated divergence time of approximately 15.4 million years ago were correlated with large and small body size, respectively. A total of 180 rapidly evolving genes and two positively selected genes were identified between the two groups. Functional enrichment analyses of these candidate genes revealed distinct enrichment categories between the two groups. These pathways and genes may play important roles in body size variation in groupers through complex regulatory networks. Based on our results, we speculate that the ancestors of the two divergent groups of groupers may have adapted to different environments through habitat selection, leading to genetic variations in metabolic patterns, organ development, and lifespan, resulting in body size divergence between the two locally adapted populations. These findings provide important insights into the genetic mechanisms underlying body size variation in groupers and species differentiation.

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Section: Discussionmentioning

confidence: 99%