The impact of diabetics and smoking on gender differences of smear positive pulmonary tuberculosis incidence

Abedi, Siavash; Moosazadeh, Mahmood; Tabrizi, Reza; Afshari, Mahdi; Nezammahalleh, Asghar; Akbari, Maryam

doi:10.1016/j.ijtb.2017.01.004

Cited by 6 publications

(15 citation statements)

References 13 publications

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“…Our findings show a higher prevalence of smear-positive PTB among males than females. This finding corroborates with numerous studies conducted in many countries [6,7,25,26]. The M:F ratio was 1.4-4.6:1.…”

Section: Prevalence Of Smear-positive Ptbsupporting

confidence: 92%

“…Most studies conducted globally have revealed that the highest burden of TB is among males [4,5]. A similar male predominance of an approximately 2:1 ratio was also observed for PTB [6] and smear-positive PTB [7] in Southern Mexico and Iran, respectively. Nevertheless, there were also studies recorded higher smear-positive PTB prevalence among females, such as in Quetta city [8] and Hyderabad city [9] in Pakistan.…”

Section: Introductionmentioning

confidence: 55%

“…The present study shows that being a smoker is associated with smear-positive PTB among male patients. A study conducted in Iran found that men who are smokers have 98% increased risk of developing smear-positive PTB [7]. In comparison, men who are non-smokers have only 5% increased risk of developing smear-positive PTB [7].…”

Section: Plos Onementioning

confidence: 99%

“…These sex-related variations may reflect the difference in biological [10], epidemiological and socioeconomic characteristics, and cultural barriers in accessing healthcare services [11]. Findings from research exploring on sex-related differences in risk factor of PTB [5][6][7] invariably differ according to the local setting of the PTB patient's population. Therefore, it is appropriate to perform sexdifference assessment and analysis in the local context as an evidence-based for strengthening the National Strategic Plan of TB control program as recommended by WHO [11] and United Nations Development Programme [12].…”

Section: Introductionmentioning

confidence: 99%

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Sex-related differences in smear-positive pulmonary tuberculosis patients in Kuala Lumpur, Malaysia: Prevalence and associated factors

et al. 2021

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Smear-positive pulmonary tuberculosis (PTB) is more infectious compared to smear-negative PTB and have great significance for epidemiology and infection control. The prevalence of smear-positive PTB rarely affects males and females equally. Hence, we aimed to identify the sex-related differences in the prevalence of smear-positive PTB and its associated factors in Kuala Lumpur, Malaysia. A cross-sectional study was conducted using data from the National Tuberculosis Information System (TBIS) from 1 January, 2015, to 31 December, 2019. The study population was selected using simple random sampling from the list of registered PTB patients in TBIS. The criteria for inclusion were all Malaysian adults aged ≥18 years residing in Kuala Lumpur and registered as PTB in TBIS. Factors associated with smear-positive PTB in male and female patients were determined using multiple logistic regression analysis. Overall prevalence of smear-positive PTB was 68.6%, and male patients predominated (71%). The male:female prevalence ratio of smear-positive PTB was 2.4:1. Male patients who worked as machine operators and elementary workers (adjusted odds ratio (aOR) 2.23, 95% confidence interval (CI) 1.24–4.02, p = 0.007), were self-employed (aOR 2.58, 95% CI 1.46–4.56, p = 0.001), lived in a residence categorized as ‘other’ (aOR 2.49, 95% CI 1.28–4.86, p = 0.007) and were smokers (aOR 1.37, 95% CI 1.01–1.87, p = 0.045) had higher odds for smear-positive PTB. Meanwhile, female patients with diabetes mellitus had higher odds for smear-positive PTB (aOR 1.92, 95% CI 1.05–3.54, p = 0.035), while female patients who were healthcare workers had lower odds (aOR 0.33, 95% CI 0.12, 0.94, p = 0.039). The prevalence of smear-positive PTB is higher in males compared to females. The factors associated with smear-positive PTB differed based on sex. The current TB control program, especially on smear-positive PTB, should likely be strategized and stratified by sex.

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Section: Prevalence Of Smear-positive Ptbsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 55%

Section: Plos Onementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sex-related differences in smear-positive pulmonary tuberculosis patients in Kuala Lumpur, Malaysia: Prevalence and associated factors

et al. 2021

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“…The progression from MTB infection to TB disease is in uenced by multiple factors, including undernutrition, smoking, alcohol consumption, etc. (Abedi et al, 2019). In addition, host molecular regulatory mechanisms, such as gene expression regulation by microRNAs (miRNAs), may also be involved in disease progression.…”

Section: Introductionmentioning

confidence: 99%

Associations of Genetic Variants of miRNA Coding Regions With Pulmonary Tuberculosis Risk in China

Zhang

Liu

Zhu

et al. 2021

Preprint

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Background Tuberculosis (TB) is the leading cause of death caused by single pathogenic microorganism of mycobacterium tuberculosis(MTB). The study aims to explore the associations of microRNA (miRNA) single nucleotide polymorphisms (SNPs) with pulmonary TB (PTB) risk. Methods A population-based case-control study was conducted, and 168 newly diagnosed smear-positive PTB cases and 251 non-TB controls were recruited. SNPs located within miR-27a (rs895819), miR-423 (rs6505162), miR-196a-2 (rs11614913), miR-146a (rs2910164), miR-618 (rs2682818) were selected and MassARRAY® MALDI-TOF System was employed for genotyping. SPSS19.0 was adopted for statistical analysis, non-conditional logistic regression was performed. Odds ratios (ORs) and 95%confidence intervals (95%CIs) were computed to estimate the associations. Associations of haplotypes with PTB risk was performed with online tool. Results Rs895819 CT/CC genotype was associated with reduced PTB risk among female population (OR= 0.45, 95%CI: 0.23-0.98), p=0.045. Haplotypes (Combined with rs895819, rs2682818, rs2910164, rs6505162 and rs11614913) TCCCT, TAGCC, CCCCC, CCGCT and TCGAT were associated with reduced PTB risk and the ORs were 0.67 (95%CI: 0.45-0.99), 0.49 (0.25-0.94), 0.34 (95%CI: 0.14-0.81), 0.22 (95%CI: 0.06-0.84) and 0.24 (95%CI: 0.07-0.79)，respectively; while the haplotypes of TAGCT, CCCCT, CACCT and TCCAT were associated with increased PTB risk, and the ORs were 3.63 (95%CI: 1.54-8.55), 2.20 (95%CI: 1.00-4.86), 3.90 (95%CI: 1.47-10.36) and 2.95 (95%CI: 1.09-7.99), respectively. Conclusions Rs895819 CT/CC genotype was associated with reduced female PTB risk and haplotype TCCCT, TAGCC, CCCCC, CCGCT and TCGAT were associated with reduced PTB risk, while TAGCT, CCCCT, CACCT and TCCAT were associated with increased risk.

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Associations of genetic variants within TYK2 with pulmonary tuberculosis among Chinese population

Zhang,

Liu,

Zhu

et al. 2024

Molec Gen & Gen Med

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BackgroundPulmonary tuberculosis (PTB) is a common infectious disease caused by mycobacterium tuberculosis (MTB) and the present study aims to explore the associations of genetic variants within tyrosine kinases 2 (TYK2) with PTB incidence.MethodsA population‐based case control study including 168 smear‐positive PTB cases and 251 controls was conducted. Five single nucleotide polymorphisms (SNPs) including rs280520, rs91755, rs2304256, rs12720270, rs280519 located within TYK2 gene were selected and MassARRAY® MALDI‐TOF system was employed for genotyping. SPSS 19.0 was adopted for statistical analysis, non‐conditional logistic regression was conducted. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were computed to estimate their contributions to PTB incidence.ResultsIn the overall study population, rs91755 TT and rs280519 AA genotypes were found to be associated with reduced PTB risk (OR = 0.34, 95% CI: 0.16–0.72; OR = 0.38, 95% CI: 0.18–0.79, respectively). After stratification for sex, we found that among the male population, rs91755TG/TT, rs12720270AG/GG and rs280519AG/AA genotypes were associated with reduced PTB risk (OR = 0.41, 95% CI: 0.21–0.80; OR = 0.44, 95% CI: 0.21–0.94; OR = 0.42, 95% CI: 0.21–0.82, respectively). After stratification for age, we found that among those aged <60 years, rs91755TT and rs280519AA genotype were associated with reduced PTB risk (OR = 0.29, 95% CI: 0.09–0.90; OR = 0.34, 95% CI: 0.11–1.08, respectively); while rs2304256AC/AA genotype was associated with increased PTB risk (OR = 2.68, 95% CI: 1.05–6.85). Haplotype analysis revealed that AGAAG and ATCGA (Combined with rs280520, rs91755, rs2304256, rs12720270 and rs280519) were associated with increased (OR = 1.54, 95% CI: 1.01–2.37) and decreased PTB risk (OR = 0.70, 95% CI: 0.52–0.94), respectively.ConclusionsThe genetic variants located within TYK2 including rs91755, rs12720270 and rs280519 were found to be associated with modified PTB risk and the SNPs had potential to be the biomarkers to predict PTB incidence risk.

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The impact of diabetics and smoking on gender differences of smear positive pulmonary tuberculosis incidence

Cited by 6 publications

References 13 publications

Sex-related differences in smear-positive pulmonary tuberculosis patients in Kuala Lumpur, Malaysia: Prevalence and associated factors

Sex-related differences in smear-positive pulmonary tuberculosis patients in Kuala Lumpur, Malaysia: Prevalence and associated factors

Associations of Genetic Variants of miRNA Coding Regions With Pulmonary Tuberculosis Risk in China

Associations of genetic variants within TYK2 with pulmonary tuberculosis among Chinese population

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