The impact of different calibration matrices on the determination of insulin-like growth factor 1 by high-resolution-LC-MS in acromegalic and growth hormone deficient patients

Simstich, Sebastian; Züllig, Thomas; D’Aurizio, Federica; Biasotto, Alessia; Colao, Annamaria; Isidori, Andrea M.; Lenzi, Andrea; Fauler, Günter; Köfeler, Harald; Curcio, Francesco; Herrmann, Markus

doi:10.1016/j.clinbiochem.2023.02.008

Cited by 2 publications

(1 citation statement)

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“…Defining what we could consider a preserved IGF-I activity is challenging. A range of serum IGF-I values in the normal population has not yet been recorded since technical shortcomings have not been entirely solved [206][207][208]. Further, due to the complex biology of the IGF system, which includes IGF-I and -II together with six binding proteins, serum concentrations are, in all likelihood, insufficient to define IGF-I activity in target organs.…”

Section: Discussionmentioning

confidence: 99%

The Role of Insulin-like Growth Factor I in Mechanisms of Resilience and Vulnerability to Sporadic Alzheimer’s Disease

Zegarra-Valdivia,

Pignatelli,

Nuñez

et al. 2023

IJMS

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Despite decades of intense research, disease-modifying therapeutic approaches for Alzheimer’s disease (AD) are still very much needed. Apart from the extensively analyzed tau and amyloid pathological cascades, two promising avenues of research that may eventually identify new druggable targets for AD are based on a better understanding of the mechanisms of resilience and vulnerability to this condition. We argue that insulin-like growth factor I (IGF-I) activity in the brain provides a common substrate for the mechanisms of resilience and vulnerability to AD. We postulate that preserved brain IGF-I activity contributes to resilience to AD pathology as this growth factor intervenes in all the major pathological cascades considered to be involved in AD, including metabolic impairment, altered proteostasis, and inflammation, to name the three that are considered to be the most important ones. Conversely, disturbed IGF-I activity is found in many AD risk factors, such as old age, type 2 diabetes, imbalanced diet, sedentary life, sociality, stroke, stress, and low education, whereas the Apolipoprotein (Apo) E4 genotype and traumatic brain injury may also be influenced by brain IGF-I activity. Accordingly, IGF-I activity should be taken into consideration when analyzing these processes, while its preservation will predictably help prevent the progress of AD pathology. Thus, we need to define IGF-I activity in all these conditions and develop a means to preserve it. However, defining brain IGF-I activity cannot be solely based on humoral or tissue levels of this neurotrophic factor, and new functionally based assessments need to be developed.

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Section: Discussionmentioning

confidence: 99%