This systematic literature review investigates the safety aspects of in-vehicle infotainment systems (IVISs) from 2012 to 2023, analyzing 96 studies. IVISs have significantly evolved, incorporating technologies such as navigation systems, parking assistance, and video games. However, these innovations introduce safety concerns like driver distraction and cognitive overload. This review identifies six primary safety issues: driving distraction, situational awareness, cognitive load, driving performance, interaction success, and emotional state. Head-down displays and touchscreens often have negative safety implications, while speech-based interfaces and Bluetooth-integrated systems are generally considered safer. Suggested improvements include enhancing interface design for touchscreens and exploring gesture-based alternatives. Despite these developments, significant gaps remain in real-world evaluations and studies in diverse driving conditions, highlighting the need for standardized manufacturing norms. Addressing these issues is essential for creating future IVIS that are both reliable and safe. This review serves as a foundation for future research, safety regulations, and design principles aimed at improving IVIS safety. Overcoming these challenges will require a multi-faceted approach that considers user-friendly design, adaptive technologies, and predictive analytics. The goal is to balance technological advancements with road safety, ensuring that IVISs contribute to a safer driving experience without compromising convenience and functionality.