The impact of drugs on male fertility: a review

Semet, M.; Paci, Marine; Saïas-Magnan, J.; Metzler‐Guillemain, Catherine; Boissier, Romain; Lejeune, Hervé; Tcherdukian, Jessica

doi:10.1111/andr.12366

Cited by 255 publications

(178 citation statements)

References 206 publications

(366 reference statements)

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“…Male infertility may be related to disorders of spermatogenesis, post-testicular sperm maturation or sexual function ensuring ejaculation of spermatozoa. The impact of drugs on male fertility has recently been reviewed (Semet et al 2017), but still, data on drug effects or side effects on epididymal contractility is sparse. Medications that target smooth musculature potentially interfere with epididymal contraction and thus could prevent the correct maturation and transport of sperm.…”

Section: Potential Side Effects Of Medicationsmentioning

confidence: 99%

Contractility of the epididymal duct - function, regulation and potential drug effects

et al. 2018

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During their transit through the epididymis, spermatozoa mature and acquire motility and fertilizing capacity. The smooth muscle cells (SMCs) of the epididymal duct are thought to be responsible for the adequate transport of spermatozoa. Thus, precise regulation of SMC function also represents a prerequisite for sperm maturation thereby contributing to male fertility. In this review we would like to highlight various aspects of epididymal SMC function and discuss several angles with respect to regulation of contraction and relaxation. Different to the vas deferens, where disturbed SMC pathways resulting in male infertility could be defined, comparable information is missing in the epididymis. We therefore include some vas deferens data which could also be useful for a better understanding of epididymal SMC function. Furthermore, we would like to draw attention to drugs used in clinical practice and their potential (side) effects on contractions in the epididymis.

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Section: Potential Side Effects Of Medicationsmentioning

confidence: 99%

Contractility of the epididymal duct - function, regulation and potential drug effects

et al. 2018

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“…However, the consequences of APAP and NSAID exposure on the adult reproductive health are still largely unknown (22). A recent study showed the association between APAP and its metabolite p-aminophenol (quantified in urine) and reduced sperm quality in 500 male partners of couples planning for pregnancy (23).…”

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confidence: 99%

Intergenerational effects on mouse sperm quality after in utero exposure to acetaminophen and ibuprofen

et al. 2018

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Nonsteroidal antiinflammatory drugs and analgesic drugs, such as N-acetyl- p-aminophenol (APAP; acetaminophen, paracetamol), are widely used by pregnant women. Accumulating evidence has indicated that these molecules can favor genital malformations in newborn boys and reproductive disorders in adults. However, the consequences on postnatal testis development and adult reproductive health after exposure during early embryogenesis are still unknown. Using the mouse model, we show that in utero exposure to therapeutic doses of the widely used APAP-ibuprofen combination during the sex determination period leads to early differentiation and decreased proliferation of male embryonic germ cells, and early 5-methylcytosine and extracellular matrix protein deposition in 13.5 d postcoitum exposed testes. Consequently, in postnatal testes, Sertoli-cell maturation is delayed, the Leydig-cell compartment is hyperplasic, and the spermatogonia A pool is decreased. This results in a reduced production of testosterone and in epididymal sperm parameter defects. We observed a reduced sperm count (19%) in utero-exposed (F0) adult males and also a reduced sperm motility (40%) in their offspring (F1) when both parents were exposed, which leads to subfertility among the 6 mo old F1 animals. Our study suggests that the use of these drugs during the critical period of sex determination affects the germ-line development and leads to adverse effects that could be passed to the offspring.-Rossitto, M., Marchive, C., Pruvost, A., Sellem, E., Ghettas, A., Badiou, S., Sutra, T., Poulat, F., Philibert, P., Boizet-Bonhoure, B. Intergenerational effects on mouse sperm quality after in utero exposure to acetaminophen and ibuprofen.

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“…Concurrently, there has been a global decline in semen parameters, while the prevalence of hypogonadism remains high (Araujo et al, ; Levine et al, ; Mulligan, Frick, Zuraw, Stemhagen, & McWhirter, ). Though no link has been suggested between NSAID use and these epidemiologic trends, a few small studies over the past decade have suggested a spermatotoxic effect of select NSAIDS (Semet et al, ). Due to a lack of quality evidence, the true effect of NSAIDs on male reproductive physiology has remained understudied and unknown, yet these agents have been generally considered safe for use in men, with little concern for impact on gonadal function.…”

Section: Introductionmentioning

confidence: 99%

Effects of nonsteroidal anti‐inflammatory drug (NSAID) use upon male gonadal function: A national, population‐based study

et al. 2020

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Recent data have suggested that short‐term NSAID use induces a state of compensated hypogonadism. Our aim was to investigate the association between chronic, regular NSAID use and compensated hypogonadism in a large, nationally representative cohort, the US National Health and Nutrition Examination Survey (NHANES) database. Men 20–80 years who answered the analgesic use questionnaire and underwent hormonal testing were included. Multivariable regression was utilised to determine the relationship between NSAID use and serum testosterone (T), anti‐Mullerian hormone (AMH) and T:AMH ratio. Among 3,749 men, 505 (13.5%) reported regular NSAID use and 3,244 (86.5%) did not. Regular users had lower T (440.7 ± 27.0 vs. 557.0 ± 24.9 ng/dl, p = .005) and albumin (43.8 ± 0.2 vs. 45.1 ± 0.1, p < .001) compared to nonregular users. On multivariable analysis, only active smoking was significantly associated with T, AMH and T:AMH ratio (p < .001, p = .036 and p = .005 respectively). Regular NSAID use was not associated with T, AMH or T:AMH ratio (p = .523, p = .974, and p = .872 respectively). In this nationally representative sample of US men, regular and chronic NSAID use was not associated with alterations in T or compensated hypogonadism. These data should reassure patients and clinicians regarding the safety of NSAID use with respect to the risk of alteration in the hypothalamic–pituitary–gonadal axis.

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The impact of drugs on male fertility: a review

Cited by 255 publications

References 206 publications

Contractility of the epididymal duct - function, regulation and potential drug effects

Contractility of the epididymal duct - function, regulation and potential drug effects

Intergenerational effects on mouse sperm quality after in utero exposure to acetaminophen and ibuprofen

Effects of nonsteroidal anti‐inflammatory drug (NSAID) use upon male gonadal function: A national, population‐based study

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