2023
DOI: 10.1186/s13052-023-01414-x
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The impact of early empirical antibiotics treatment on clinical outcome of very preterm infants: a nationwide multicentre study in China

Abstract: Background Infants with rule-out infections are responsible for the majority of empirical antibiotics treatment (EAT) in neonatal intensive care units (NICUs), particularly very preterm infants (VPIs). Antibiotic overuse has been linked to adverse outcomes. There is a paucity of data on the association between EAT and clinical outcomes (containing the nutritional outcomes) of VPIs without infection-related morbidities. Methods Clinical data of VPIs… Show more

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“…However, in preterm, very low-birthweight infants, each day of antibiotic treatment has been associated with an increased risk of late-onset sepsis, NEC, or death [ 97 ]. Indeed, such exposure to early antibiotics can impact the developing gut microbiome [ 98 ], gastrointestinal transit [ 99 ], stool patterns, and oral feeding tolerance [ 100 , 101 ].…”
Section: Antibiotics and Acid Suppressants Can Impact The Development...mentioning
confidence: 99%
“…However, in preterm, very low-birthweight infants, each day of antibiotic treatment has been associated with an increased risk of late-onset sepsis, NEC, or death [ 97 ]. Indeed, such exposure to early antibiotics can impact the developing gut microbiome [ 98 ], gastrointestinal transit [ 99 ], stool patterns, and oral feeding tolerance [ 100 , 101 ].…”
Section: Antibiotics and Acid Suppressants Can Impact The Development...mentioning
confidence: 99%