2021
DOI: 10.1002/jdn.10108
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The impact of early life stress and immune challenge on behavior and glia cells alteration in late adolescent rats

Abstract: Maternal deprivation (MD) is known to be related to long‐term changes that could influence the onset of psychiatric disorders. Studies have demonstrated that early life stress makes the cells in the brain more susceptible to subsequent stressors. To test it, we used an animal model of MD conducted from postnatal day (PND) 1 to 10. Deprived and non‐deprived rats (control) were randomized to receive or not lipopolysaccharide (LPS) at 5 mg/kg on PND 50. The behavior and glial cells activation were evaluated in al… Show more

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Cited by 4 publications
(1 citation statement)
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“…The lasting impact of ELS is particularly noteworthy here as both studies induced brain injury more than a month after ELS, and in the Sanchez et al report, a stress challenge (30 min of restraint) 8 weeks after TBI induced an exacerbated increase in glucocorticoids levels in brain injured mice that experienced ELS. These data are consistent with similar reports in other disease states, indicating that neuroinflammatory priming by ELS exacerbates amyloid pathology in a mouse model of Alzheimer's Disease ( Hoeijmakers et al, 2017 ) as well as behavioral and inflammatory responses to an immune challenge in adulthood ( Reus et al, 2021 ; Viola et al, 2019 ).…”
Section: Early Life Stress Exacerbates the Inflammatory Response To Tbisupporting
confidence: 91%
“…The lasting impact of ELS is particularly noteworthy here as both studies induced brain injury more than a month after ELS, and in the Sanchez et al report, a stress challenge (30 min of restraint) 8 weeks after TBI induced an exacerbated increase in glucocorticoids levels in brain injured mice that experienced ELS. These data are consistent with similar reports in other disease states, indicating that neuroinflammatory priming by ELS exacerbates amyloid pathology in a mouse model of Alzheimer's Disease ( Hoeijmakers et al, 2017 ) as well as behavioral and inflammatory responses to an immune challenge in adulthood ( Reus et al, 2021 ; Viola et al, 2019 ).…”
Section: Early Life Stress Exacerbates the Inflammatory Response To Tbisupporting
confidence: 91%