The Impact of Early Nutrition in Premature Infants on Later Childhood Insulin Sensitivity and Growth

Regan, Fiona; Cutfield, Wayne S.; Jefferies, Craig; Robinson, Elizabeth; Hofman, Paul L.

doi:10.1542/peds.2006-0733

Cited by 86 publications

(71 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Low protein intake in the first 3 mo of life occurred in the premature group, which was proposed as the trigger to epigenetic modification of genes involved in glucose regulation (47). Other factors such as prenatal or neonatal glucocorticoid exposure and illness in the neonatal period were not associated with insulin sensitivity (46).…”

Section: Childhood Clinical Characteristicsmentioning

confidence: 99%

Could Epigenetics Play a Role in the Developmental Origins of Health and Disease?

et al. 2007

View full text Add to dashboard Cite

show abstract

Section: Childhood Clinical Characteristicsmentioning

confidence: 99%

Could Epigenetics Play a Role in the Developmental Origins of Health and Disease?

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Nutritional advice that is offered to parents in the future will need to reflect the importance of avoiding excess growth (Ekelund et al 2006). Whilst optimal growth rate may differ between individuals, avoiding excess growth is also an important consideration Woods et al 2001 in the nutritional support offered to previously-sick and/or premature infants in their recovery phase when it may have the potential to improve later cardiovascular health (Regan et al 2006).…”

Section: Nutritional Programming Of the Kidney And Its Relationship Wmentioning

confidence: 99%

Integration of physiological and molecular mechanisms of the developmental origins of adult disease: new concepts and insights

Symonds

2007

Proc. Nutr. Soc.

View full text Add to dashboard Cite

It is now well established that an imbalance or reduction in the maternal diet either through pregnancy and lactation or at defined time points therein can have long-term effects on cardiovascular and metabolic health in the resulting offspring; the exact outcome varying greatly with the period of development or growth targeted. The EARly Nutrition programming -longterm follow up of Efficacy and Safety Trials and integrated epidemiological, genetic, animal, consumer and economic research (EARNEST), or metabolic programming, project aims to determine the primary physiological and molecular mechanisms that cause long-term changes in both cardiovascular function and metabolic homeostasis. Thereafter, it also aims to examine nutritional interventions that could be adopted in order to overcome such complications. The present review summarises some of the more recent findings from a range of nutritional interventions in both small and large animals that are beginning to uncover novel pathways by which long-term health can be determined. These interventions include nutritional manipulations that can increase or decrease blood pressure in the resulting offspring as well as indicating their dissociation from adaptations in the kidney. Particular emphasis will be placed on growth during lactation in conjunction with the extent to which central and peripheral tissue adaptations can act to amplify, or protect, the offspring from later disease when born to nutritionallymanipulated mothers.

show abstract

“…Barker et al [13] documented the association of LBW and low weight gain in the first year of life with death from ischemic heart disease. Recent studies focusing on excessive weight gain in early life have also shown that LBW combined with rapid weight gain in early infancy is associated with greater risk for the development of obesity [14], hypertension [15], insulin resistance [16] [17], and cardiovascular disease [18]. Therefore, growth among LBW infants is thought to influence the occurrence of noncommunicable diseases in later life.…”

Section: Introductionmentioning

confidence: 99%

Underweight and Obesity in Low Birth Weight Children in Early Infancy in Japan

Kato¹,

Kubota²,

Saito³

et al. 2015

FNS

View full text Add to dashboard Cite

Introduction: Although there are several reports on the prevalence of underweight or obesity in low birth weight (LBW, <2.5 kg) children, there are few longitudinal studies from birth to early infancy. Methods: We enrolled 177 (93 boys) LBW and 2485 (1267 boys) normal birth weight (NBW, ≥2.5 and <4.0 kg) children. Height and weight data at birth and at 1.5, 3.5, and 5 years were obtained from mother-health child records. Underweight and obesity were defined as <5 th percentile and ≥90 th percentile of the body mass index (BMI), respectively, based on reference values for Japanese children. Results: LBW children had accelerated growth from birth to age 3.5 years, but at Age 5, both sexes had significantly lesser height and weight z-scores, with notably lesser BMI percentile scores for girls, compared with NBW children. The prevalence of underweight was significantly higher in the LBW children throughout the study period. There were no significant differences in the prevalence of obesity between the two groups, except for at birth. Multiple regression analysis revealed that small-for-gestational age was associated with underweight at Age 5 years. Conclusions: This study indicates that, up to Age 5, underweight is a more serious problem than obesity in LBW children. Our results suggest that careful observation of growth from early infancy is necessary to prevent the occurrence of underweight in early infancy.

show abstract

The Impact of Early Nutrition in Premature Infants on Later Childhood Insulin Sensitivity and Growth

Cited by 86 publications

References 49 publications

Could Epigenetics Play a Role in the Developmental Origins of Health and Disease?

Could Epigenetics Play a Role in the Developmental Origins of Health and Disease?

Integration of physiological and molecular mechanisms of the developmental origins of adult disease: new concepts and insights

Underweight and Obesity in Low Birth Weight Children in Early Infancy in Japan

Contact Info

Product

Resources

About