The Impact of Echocardiographic Epicardial Fat Thickness on Outcomes of Cryoballoon‐Based Atrial Fibrillation Ablation

Canpolat, Uğur; Aytemir, Kudret; Yorgun, Hikmet; Asil, Serkan; Dural, M.; Özer, Necla

doi:10.1111/echo.13193

Cited by 25 publications

(19 citation statements)

References 28 publications

(68 reference statements)

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“…Most of the articles (7/10) were in the full-text format, while three articles were in the conference abstract [17,19,20]. CT [[15], [16], [17],[19], [20], [21], [22], [23]] and echocardiography [18,24] were the used imaging modalities for EFT measurements. The least sample size was 38 [17], and the largest ones were related to Chao et al, [18] with 283 patients.…”

Section: Resultsmentioning

confidence: 99%

“…The least sample size was 38 [17], and the largest ones were related to Chao et al, [18] with 283 patients. The first article was published in 2011 [15], and the latest article in 2016 [24] (Table 1). Other characteristics of the included studies including study location, type of ablation, follow-up duration, age, body mass index (BMI), and gender distribution are shown in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…The abundance of EFT and post-ablation AF recurrence was firstly described by Tsao et al; while more than ten different studies have investigated this association up to now [15]. However, these studies have been conducted in different populations, various disease stages (paroxysmal or persistent AF), a variety of EFT measurement methods (computed tomography (CT) or echocardiography), numerous methods of rhythm control strategy (CA or CBA), and diverse intervals of follow-up for AF recurrence [[16], [17], [18], [19], [20], [21], [22], [23], [24]]. The present study was the first attempt to verify the association between AF recurrence and EFT, conducting a meta-analysis of investigations comparing patients with and without AF recurrence after ablation.…”

Section: Introductionmentioning

confidence: 99%

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Is epicardial fat tissue associated with atrial fibrillation recurrence after ablation? A systematic review and meta-analysis

Shamloo

Dagres

Dinov

et al. 2019

IJC Heart & Vasculature

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IntroductionAlthough an undoubted association between epicardial fat tissue (EFT) and atrial fibrillation (AF) has been recently approved, the association between EFT and post-ablation AF recurrence is not evident yet. This study aimed to assess the association between EFT and AF recurrence after ablation.MethodsThe present study was a systematic review and meta-analysis using related literature available in electronic databases until July 2018 via “atrial fibrillation” and “epicardial fat” as the main keywords. Considering the different methods of EFT measurement, three different pooled meta-analyses were conducted in this study including: 1) comparison of total EFT volume, 2) left atrium (LA)-EFT volume, and 3) EFT thickness between two groups with and without AF recurrence estimating standardized mean difference (SMD) through a random and non-random effect meta-analysis. Statistical analysis was also performed using Comprehensive Meta-analysis (CMA) Software.ResultsFollowing a search into a total number of 518 articles, the findings of 12 studies published in 10 articles were enrolled in this meta-analysis. Accordingly, the results of meta-analysis showed that LA-EFT and total EFT volumes were higher in recurrent subjects (LA-EFT: SMD = 0.862 ml; I2 = 0.00, 95% confidence interval (CI) = 0.567–1.156; total EFT: SMD = 1.017 ml, I2 = 0.00, 95% CI = 0.748–1.286). Besides, a significant higher EFT thickness in patients with AF recurrence compared to those with no AF recurrence was observed (SMD = 0.808 mm, I2 = 91.07, 95% CI = 0.215–1401).ConclusionThe total EFT and LA-EFT volumes, as well as EFT thickness, seemed to be associated with AF recurrence in patients undergoing AF ablation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Is epicardial fat tissue associated with atrial fibrillation recurrence after ablation? A systematic review and meta-analysis

Shamloo

Dagres

Dinov

et al. 2019

IJC Heart & Vasculature

View full text Add to dashboard Cite

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“…12,13 In addition, the relationship between EFT and AF incidence and that between EFT and AF recurrence has been reported in recent years, both after ablation and electrical cardioversion. [14][15][16]21,22 Although no significant difference was observed regarding the median EFT between early and late conversion groups, Obesity has been shown as an independent risk factor for AF. 12,23 However, the association between EpF and AF has been observed to be independent of obesity.…”

Section: Discussionmentioning

confidence: 88%

Predictors of time to conversion of new‐onset atrial fibrillation to sinus rhythm with amiodarone therapy

Dursun

Şahin

Bayraktar

et al. 2020

Journal of Arrhythmia

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Background New‐onset atrial fibrillation (AF) is a frequent cause of presentation to the emergency department (ED). Epicardial fat thickness (EFT) is associated with the presence and recurrence of AF. However, no study has investigated the predictors of the time to conversion of AF to sinus rhythm with amiodarone therapy. The aim of this study was to investigate predictors of time to conversion of AF to sinus rhythm in patients with new‐onset AF. Methods A total of 122 patients admitted to the ED with symptoms of hemodynamically stable new‐onset AF (lasting <48 hours) were registered consecutively. These patients received intravenous amiodarone. EFT was measured using 2D echocardiography in parasternal long‐axis views. Results A significant positive correlation was determined between EFT and conversion time (rho = 0.267, P = .017) in all patients. The median time for conversion from the start of amiodarone infusion was 410 min (150‐830 minutes). Based on the median conversion time, patients were classified as early conversion (time < 410 minutes; n = 41) and late conversion (time > 410 minutes; n = 40). Multivariate logistic regression analysis demonstrated that EFT (P = .033, odds ratio [OR]: 1.68, 95% confidence interval [CI]: 1.6‐2.7), higher troponin I level > 0.04 (P = .034, OR: 5.3, 95% CI: 1.1‐24.8), and lower age (P = .003, OR: 0.8, 95% CI: 0.8‐0.9) were significantly associated with longer conversion time. Conclusions We determined that EFT and high troponin level affected the time to conversion to sinus rhythm in patients with new‐onset AF.

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“…Although it is found to be related with cardiovascular and metabolic risk fac-tors, as in our study [17], a study by Nelson et al [5] revealed a weak correlation between EAT and Framingham risk score and no correlation with subclinical atherosclerosis assessed by carotid intima-media thickness, carotid artery plaque, and coronary artery calcium score. However, recently Canpolat et al [18] clarified that EAT measured by echocardiography independently predicted the AF recurrence after cryoablation and was also positively correlated with high-sensitivity C-reactive protein as an indicator of systemic inflammation. This discrepancy may be due to the different nature of study populations.…”

Section: Discussionmentioning

confidence: 99%

Clinical usefulness of epicardial adipose tissue in patients with high-intermediate pre-test probability for coronary artery disease

et al. 2018

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The Impact of Echocardiographic Epicardial Fat Thickness on Outcomes of Cryoballoon‐Based Atrial Fibrillation Ablation

Cited by 25 publications

References 28 publications

Is epicardial fat tissue associated with atrial fibrillation recurrence after ablation? A systematic review and meta-analysis

Is epicardial fat tissue associated with atrial fibrillation recurrence after ablation? A systematic review and meta-analysis

Predictors of time to conversion of new‐onset atrial fibrillation to sinus rhythm with amiodarone therapy

Clinical usefulness of epicardial adipose tissue in patients with high-intermediate pre-test probability for coronary artery disease

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