The impact of educational materials on compliance and persistence rates with adjuvant aromatase inhibitor treatment: First-year results from the Compliance of ARomatase Inhibitors AssessmenT In Daily practice through Educational approach (CARIATIDE) study

Abstract

The CARIATIDE study was designed to assess the impact of educational materials (EMs) on compliance and persistence rates with aromatase inhibitor (AI) treatment in postmenopausal women with hormone-receptor-positive early breast cancer. Patients were randomized to standard AI treatment (Group A; N = 1379) or standard AI treatment plus EMs containing information on a range of breast-cancer-related topics (Group B; N = 1379). Standardized questionnaires assessed investigator-perceived levels of care and evaluated patient compliance and behavior. At 1 year, there was no significant difference in compliance between Group A and Group B (81% vs. 82%, p = 0.4524). However, higher compliance in patients receiving EMs was observed in Sweden/Finland (p = 0.0246). Compliance with initial AI and persistence rate were not significantly altered by EM. Other factors associated with improved compliance, irrespective of EMs, e.g. administration of chemotherapy were identified.

Behavioral Interventions to Enhance Adherence to Hormone Therapy in Breast Cancer Survivors: A Systematic Literature Review

“…In relation to the interventions, three of the studies tested the German-based PACT study intervention but in different contexts. 14, 24, 25 In relation to the study design, 80% (n=4) of the papers consisted of randomized controlled trials (RCT; n=4), all included an educational component (100%; n=5), and 60% incorporated reminders (n=3). All interventions were targeted towards patients (100%; n=5).…”

“…Adjuvant hormonal therapy adherence and persistence were expressed as proportions and were either abstracted 14, 24 or calculated 25, 26 based on reported data by two authors (TL and CD). Odds ratios (OR) and its 95% CI comparing adherence and persistence with adjuvant hormonal therapy in the intervention compared to the usual care group were also calculated from study results and are presented in Tables 3 and 4.…”

Breast Cancer Survivorship: A Comprehensive Review of Long-Term Medical Issues and Lifestyle Recommendations

“…451 Other studies have noted no improvement in patients given additional education materials or increased support services. 452,453 Going forward, technologic advances such as the widespread use of electronic medical records, sophisticated prescription bottles with built-in reminder timers, and effective pharmacy tracking systems may lead to further improvements. Simplified dosing regimens, as well as seamless access to refills, may also help improve compliance.…”

A Systematic Review of Adherence to Oral Antineoplastic Therapies

“…Five of these studies were randomized trials, none of which demonstrated significant differences between the intervention and control groups with respect to their primary adherence outcomes [44,45,47,52,54]. One randomized, three-arm trial did show differences in adherence, favoring the intervention groups, when the investigators conducted a post hoc pooled analysis comparing both interventions to the control group [47].…”

“…In a total of 12 studies ( [44][45][46][47], treatment monitoring [48], pharmacy-based programs [42,49,50], counseling programs [51,52], prefilled pill boxes [53], and automated voice response systems [54]. Five of these studies were randomized trials, none of which demonstrated significant differences between the intervention and control groups with respect to their primary adherence outcomes [44,45,47,52,54].…”