More than ever, engaging a multidisciplinary approach in decision-making displays an arsenal ofcapacity necessary for success across managerial concerns in all sectors of the economy. Psychology andeconomics capturing human behaviors form part of this interdisciplinary research that spans the years thoughmany are far from this reality. The paper shows the impact of neuro-economics on strategic financialdecisions in multinational enterprises deploying theories of decisions, utility, and expectations across MNCsin the media industry in Nigeria while addressing the effects of emotions affecting advertising outcomes andbranding, and financial decisions building the theoretical framework from resources from Google Scholar andScopus search engines. Utilizing five MNCs as a sample in a population of 15 registered media firms inNigeria, the study uses grounded theory methodology and focus group discussions to uncover the reality ofemotional influence on strategic decisions and multiple regression analysis to test for the statisticalsignificance of independent variables on the dependent variable. The output shows that neuro-economicscontributes significantly to all economic decision-making in all sectors, including the media industry.Although research generalization is challenging due to economic variations in different markets, the reportposts resourceful information for policy-making decisions, productivity, and wealth creation.