The impact of epididymal and accessory sex gland function on sperm motility

Elzanaty, Saad; Richthoff, Jonas; Malm, Johan; Giwercman, Aleksander

doi:10.1093/humrep/17.11.2904

Cited by 132 publications

(104 citation statements)

References 41 publications

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“…Biochemical markers of epididymal function (neutral α--glucosidase, NAG), prostatic function (prostate--specific antigen (PSA) and zinc) and seminal vesicle function (fructose) were assessed as described before (Elzanaty et al, 2002). NAG activity was measured using a commercial assay (Episcreen; Fertipro, Beernem, Belgium) according to the manufacturer's protocol.…”

Section: Accessory Gland Markersmentioning

confidence: 99%

Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men

Brokken¹,

Rylander²,

Jönsson³

et al. 2013

Molecular and Cellular Endocrinology

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Recently the dogma that there is an inverse linear association between androgen receptor (AR) CAG and GGN polymorphisms and receptor activity has been challenged. We analysed the pattern of association between 21 male reproductive phenotypes and AR CAG/GGN repeat lengths in 557 proven--fertile men.A linear association was only found between sperm DNA fragmentation index (DFI) and CAG length, and between inhibin B and GGN length. Men with longer CAG then the reference (22--24), had higher oestradiol levels, whereas men with shorter CAG stretches had a higher DFI and a higher proportion of Fas--positive germ cells. Subjects with either short or long CAG had increased seminal levels of prostate--specific antigen and neutral α--glucosidase activity. Compared to men with the median GGN length of 23, those with shorter GGN repeats had higher levels of inhibin B, higher proportions of normal and progressive sperm, and a higher fraction of Fas--positive sperm, while men with longer GGN had higher oestradiol levels.These data indicate that at least for some markers of male reproductive function the association with CAG or GGN repeat length is curvilinear.

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Section: Accessory Gland Markersmentioning

confidence: 99%

Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men

Brokken¹,

Rylander²,

Jönsson³

et al. 2013

Molecular and Cellular Endocrinology

Self Cite

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“…Prostate-specific-antigen (PSA) and a-glucosidase, markers secreted by the prostate and the epididymis, respectively, decrease with age and are positively correlated to sperm motility (Elzanaty et al, 2002;Elzanaty, 2007). Age-dependent alterations of the epididymis might lead to disturbed mitochondrial functioning, as an important part of epididymal sperm maturation is the activation of sperm mitochondria , which could by itself already be altered via genetic mechanisms, as highlighted below.…”

Section: Paternal Age Testicular Morphology and Semen Parametersmentioning

confidence: 99%

Paternal age and reproduction

Sartorius

Nieschlag

2009

Human Reproduction Update

291

212

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background: Due to various sociological factors, couples in developed countries are increasingly delaying childbearing. Besides ethical, economical and sociological issues, this trend presents us with several complex problems in reproduction. Although it is well-known that maternal age has a negative effect on fertility and increases the risk of adverse outcome during pregnancy and in offspring, the paternal influence on these outcomes is less well researched and not well-known.methods: We performed a systematic search of PubMed, and retrieved original articles and review articles to update our previous survey in this journal.results: This review highlights the link between male age and genetic abnormalities in the germ line and summarizes the knowledge about the effects of paternal age on reproductive function and outcome. Increasing paternal age can be associated with decreasing androgen levels, decreased sexual activity, alterations of testicular morphology and a deterioration of semen quality (volume, motility, morphology). Increased paternal age has an influence on DNA integrity of sperm, increases telomere length in spermatozoa and is suggested to have epigenetic effects. These changes may, at least in part, be responsible for the association of paternal age over 40 years with reduced fertility, an increase in pregnancy-associated complications and adverse outcome in the offspring. conclusion: Although higher maternal age can be an indication for intensive prenatal diagnosis, including invasive diagnostics, consideration of the available evidence suggests that paternal age itself, however, provides no rationale for invasive procedures.

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“…These constituents include potassium, semenogelin, bicarbonate, fructose, magnesium, prostaglandins, ascorbic acid, calcium, zinc, citric acid, seminal vesicle proteins, prostate-specific antigen and albumin (Harrison and Lewis 1986;Mortimer 1994;Lewis-Jones et al 1996;Gonzales 2001;Jeyendran 2003;Owen and Katz 2005). Fructose in human semen provides energy for the motile sperm (Lewis-Jones et al 1996;Elzanaty et al 2002). Accordingly, measurement of seminal fructose has been used in fertility labs and by the World Health Organization as a marker of seminal vesicle function (Harrison and Lewis 1986;Gonzales 2001).…”

Section: Summary Of Some Measures Of Semen and Sperm Qualitymentioning

confidence: 99%

Aging in male primates: reproductive decline, effects of calorie restriction and future research potential

Sitzmann

Urbanski

Ottinger

2008

AGE

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Although less dramatic than in females, male mammals experience decreasing reproductive function during aging. In primates, multiple facets of the hypothalamic-pituitary-gonadal axis show evidence of gradual age-related decline, including behavioral, neuroendocrine and endocrine alterations such as decreased testosterone levels, reduced circulating dehydroepiandrosterone sulfate (DHEAS) levels, increased numbers of sperm abnormalities, and a general decline in physiological responses. In this review we consider a range of age-related changes in males. These measures, including more subtle aging characteristics, are interesting additional indices for detecting the timing of age-related changes in behavioral, neuroendocrine, and endocrine responses. Evidence of potential effects of calorie restriction as an intervention in reproductive aging is also discussed. A discernable decline occurs in both metabolic and reproductive endocrine processes during male aging. This cascade of events includes neuroendocrine and behavioral changes; biomarkers such as circulating DHEAS also show clear age-related decline. The varied changes that occur during male aging are considered in the context of primate aging in general.

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The impact of epididymal and accessory sex gland function on sperm motility

Cited by 132 publications

References 41 publications

Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men

Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men

Paternal age and reproduction

Aging in male primates: reproductive decline, effects of calorie restriction and future research potential

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