2021
DOI: 10.3390/life11040353
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The Impact of Epigallocatechin Gallate and Coconut Oil Treatment on Cortisol Activity and Depression in Multiple Sclerosis Patients

Abstract: (1) Background: Multiple sclerosis (MS) is pathogenically characterized by high oxidative stress and symptomatically by progressive muscle loss and increased body fat associated with the presence of depression. Epigallocatechin gallate (EGCG) (particularly present in green tea) and ketone bodies (in particular beta-hydroxybutyrate (BHB)), whose main source is coconut oil, have shown emotional benefits and body fat loss. The aim of this study was to assess the impact of EGCG and coconut oil on cortisol activity… Show more

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Cited by 14 publications
(30 citation statements)
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References 57 publications
(60 reference statements)
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“…The 46 included studies were conducted between 1999 and 2021. Thirty-six out of the 46 studies selected were clinical trials [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 ] and 10 studies were observational cohort studies [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 ]. Among the 36 included clinical trials, 31 were RCTs with an average number of 67.4 randomized participants.…”
Section: Resultsmentioning
confidence: 99%
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“…The 46 included studies were conducted between 1999 and 2021. Thirty-six out of the 46 studies selected were clinical trials [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 ] and 10 studies were observational cohort studies [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 ]. Among the 36 included clinical trials, 31 were RCTs with an average number of 67.4 randomized participants.…”
Section: Resultsmentioning
confidence: 99%
“…Most of the studies measured depression symptomatology in disease states, including osteopenia [ 52 ], osteoarthritis [ 45 ], fibromyalgia [ 55 ], multiple sclerosis [ 47 , 63 ], neurodegeneration or age-associated cognitive decline [ 32 , 38 , 39 , 54 ], obesity/overweight [ 34 , 49 ], schizophrenia and bipolar disorder [ 43 , 56 ] and chronic hepatitis C infection [ 44 ]. Sixteen of the studies were in perimenopausal, menopausal, or postmenopausal women [ 31 , 33 , 35 , 36 , 37 , 42 , 48 , 50 , 51 , 52 , 53 , 61 , 62 , 64 , 70 , 71 ].…”
Section: Resultsmentioning
confidence: 99%
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