The impact of epilepsy on academic achievement in children with normal intelligence and without major comorbidities: A systematic review

Wo, Su Woan; Ong, Lai Choo; Low, Wah Yun; Lai, Pauline Siew Mei

doi:10.1016/j.eplepsyres.2017.07.009

Cited by 34 publications

(30 citation statements)

References 35 publications

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“…Considering the high prevalence of functional disabilities (e.g., learning difficulties) among PWE, routine screening of all PWE for early detection and appropriate management of any cognitive dysfunction and functional disability would be a reasonable approach. 15,16 However, these findings should be seen and interpreted in the context of sociocultural backgrounds. For example, in 2019, Iran's unemployment rate was estimated to be 12% of the total labor force 17 ; this is much lower than the 53% rate in PWE in the current study.…”

Section: Discussionmentioning

confidence: 91%

“…In a previous qualitative interview and focus group study involving teachers, parents, and young PWE, 7 behavioral problems and learning difficulties (consistent with "inability to study" in the current work) were cited as the main barriers to education for young PWE. 7 Inability to study 13 (19) Fear of having a seizure at school 11 (16) Other reasons 12 (17) Other reasons 6 (9)…”

Section: Discussionmentioning

confidence: 99%

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Education, Marriage, and Employment in People with Epilepsy: The Barriers that Patients Perceive

Asadi‐Pooya

Homayoun

Keshavarz

2020

International Journal of Epilepsy

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Purpose We surveyed people with epilepsy (PWE) and uncontrolled seizures on the challenges which they have had in their lives with respect to educational achievement, employment, and marriage. We tried to scrutinize their reasons and perceptions for their social underachievement and difficulties. Methods Adult patients above 25 years of age, with epileptic seizures for more than 5 years, who were investigated at Shiraz Comprehensive Epilepsy Center, from January until March 2019, were studied. We prepared a questionnaire for our study and asked whether they have any college education? If they have ever married? And, if they are employed? Results Seventy patients enrolled in our study. Age of the patients was 33 ± 6 years (range: 26–59 years) and their age at onset of epilepsy was 14 ± 9 years (range: 0–35 years). Forty-four patients (63%) never received any college education; 30 patients (43%) were single; and finally, 37 patients (53%) were unemployed. The most common reasons perceived by the patients for these life challenges were functional disability (e.g., inability to study or to work), social discrimination and stigmatization, and uncontrolled seizures and the associated consequences (i.e., fear of having seizures). Conclusion Many PWE (both men and women) and uncontrolled seizures suffer from social underachievement and challenges in their daily lives. Various strategies may help PWE to overcome these challenges.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Education, Marriage, and Employment in People with Epilepsy: The Barriers that Patients Perceive

Asadi‐Pooya

Homayoun

Keshavarz

2020

International Journal of Epilepsy

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“…5 Akibatnya banyak penderita epilepsi yang tidak terdiagnosis dan mendapat pengobatan yang tidak tepat sehingga menimbulkan dampak klinis dan psikososial yang merugikan baik penyandang maupun keluarganya, 6 adanya gangguan tidur, perasaan rendah diri, kecemasan dan depresi. [6][7][8] Beberapa studi telah menunjukkan pasien dengan epilepsi mempunyai beberapa gangguan kognitif tingkat tertentu, termasuk memori, atensi, visuospasial, fungsi ekskutif, abstraksi, dan kecepatan berpikir. 9,10 Epilepsi yang terdiagnosis pada anakanak memengaruhi secara negatif perkembangan dan maturasi otak yang mengarah pada defisit kognitif.…”

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Gambaran Fungsi Kognitif pada Pasien Epilepsi di Poliklinik Saraf RSUP Prof. Dr. R.D. Kandou Manado

Sigar¹,

Kembuan²,

Mahama³

2017

eCl

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Epilepsy is one of most common neurological disorders that causes cognitive decline. This stuayd was aimed to ascertain the overview of cognitive function in epilepsy patients at the Neurology Clinic of Prof Dr. R. D. Kandou Hospital Manado. This was a prospective descriptive study with a cross-sectional design. Data were obtained through anamnesis and direct test to 35 epileptic patients by using questionnaire, MMSE, and Ina-MoCA instruments in the Neurology Clinic of Prof. Dr. R. D. Kandou Hospital Manado from October to November 2017. The results MMSE showed 77.10% of patients had normal cognitive function. Meanwhile, the Ina-MoCa resulted in 89% of respondents suffering from cognitive decline. Conclusion: There were impaired cognitive functions ranging from mild to severe in epileptic patients that could affect their quality of life and functional status.Keywords: epilepsy, cognitive function Abstrak: Epilepsi adalah salah satu gangguan neurologik yang terbanyak yang menyebabkan gangguan fungsi kognitif. Penelitian ini bertujuan untuk mengetahui gambaran fungsi kognitif pada pasien epilepsi di Poliklinik Saraf RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif prospektif dengan desain potong-lintang. Pengumpulan data diperoleh melalui wawancara dan pengujian langsung terhadap pasien epilepsy yang berjumlah 35 orang. Penelitian ini menggunakan kuesioner, serta instrumen MMSE dan Ina-MoCA dilakukan di Poliklinik Saraf RSUP Prof Dr. R. D. Kandou Manado sejak bulan Oktober s/d November 2017. Hasil pemeriksaan dengan MMSE menunjukkan 77,10% dari pasien dengan fungsi kognitif normal sedangkan pemeriksaan dengan Ina-MoCA menunjukkan 89% dari pasien mengalami gangguan fungsi kognitif. Simpulan: Terdapat gangguan fungsi kognitif ringan-berat pada pasien epilepsi yang dapat memengaruhi kualitas hidup dan status fungsional.Kata kunci: epilepsi, fungsi kogntif

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“…Seizures and epilepsy are associated with neurodevelopmental conditions, such as autism spectrum disorders [3], attention-deficit hyperactivity disorder, and cognitive impairment [4][5][6][7]. Moreover, epilepsy with or without intellectual impairment is associated with low academic achievement [8].…”

Section: Introductionmentioning

confidence: 99%

Epigenome-wide association study of seizures in childhood and adolescence

et al. 2020

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The occurrence of seizures in childhood is often associated with neurodevelopmental impairments and school underachievement. Common genetic variants associated with epilepsy have been identified and epigenetic mechanisms have also been suggested to play a role. In this study, we analyzed the association of genome-wide blood DNA methylation with the occurrence of seizures in~800 children from the Avon Longitudinal Study of Parents and Children, UK, at birth (cord blood), during childhood, and adolescence (peripheral blood). We also analyzed the association between the lifetime occurrence of any seizures before age 13 with blood DNA methylation levels. We sought replication of the findings in the Generation R Study and explored causality using Mendelian randomization, i.e., using genetic variants as proxies. The results showed five CpG sites which were associated cross-sectionally with seizures either in childhood or adolescence (1-5% absolute methylation difference at p FDR < 0.05), although the evidence of replication in an independent study was weak. One of these sites was located in the BDNF gene, which is highly expressed in the brain, and showed high correspondence with brain methylation levels. The Mendelian randomization analyses suggested that seizures might be causal for changes in methylation rather than vice-versa. In conclusion, we show a suggestive link between seizures and blood DNA methylation while at the same time exploring the limitations of conducting such study.

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The impact of epilepsy on academic achievement in children with normal intelligence and without major comorbidities: A systematic review

Cited by 34 publications

References 35 publications

Education, Marriage, and Employment in People with Epilepsy: The Barriers that Patients Perceive

Education, Marriage, and Employment in People with Epilepsy: The Barriers that Patients Perceive

Gambaran Fungsi Kognitif pada Pasien Epilepsi di Poliklinik Saraf RSUP Prof. Dr. R.D. Kandou Manado

Epigenome-wide association study of seizures in childhood and adolescence

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