2015
DOI: 10.1007/s13365-015-0411-6
|View full text |Cite
|
Sign up to set email alerts
|

The impact of ethnicity/race on the association between the Veterans Aging Cohort Study (VACS) Index and neurocognitive function among HIV-infected persons

Abstract: The Veterans Aging Cohort Study (VACS) Index was developed as a risk index for health outcomes in HIV, and it has been consistently associated with mortality. It shows a significant, yet relatively weak, association with neurocognitive impairment, and little is known about its utility among ethnic/racial minority groups. We examined whether the association between the VACS Index and neurocognition differed by ethnic/racial group. Participants included 674 HIV-infected individuals (369 non-Hispanic whites, 111 … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
8
0

Year Published

2018
2018
2023
2023

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 27 publications
(8 citation statements)
references
References 40 publications
0
8
0
Order By: Relevance
“…The Veterans Aging Cohort Study (VACS) Index is a validated predictor of morbidity and mortality for people with HIV by incorporating markers of organ system injury with traditional HIV disease estimates (17)(18)(19). The VACS Index is shown to correlate with age-related complications (i.e., frailty and cognitive impairment) and can inform mechanistic studies on the pathophysiologic effects of aging with HIV (15,(20)(21)(22)(23)(24)(25). Evaluating soluble mediators with these clinical index scores and discovering novel correlations can provide a deeper understanding of the interplay between biological function and outcomes of morbidity and mortality in PAWH (26).…”
Section: Introductionmentioning
confidence: 99%
“…The Veterans Aging Cohort Study (VACS) Index is a validated predictor of morbidity and mortality for people with HIV by incorporating markers of organ system injury with traditional HIV disease estimates (17)(18)(19). The VACS Index is shown to correlate with age-related complications (i.e., frailty and cognitive impairment) and can inform mechanistic studies on the pathophysiologic effects of aging with HIV (15,(20)(21)(22)(23)(24)(25). Evaluating soluble mediators with these clinical index scores and discovering novel correlations can provide a deeper understanding of the interplay between biological function and outcomes of morbidity and mortality in PAWH (26).…”
Section: Introductionmentioning
confidence: 99%
“…Although lower nadir CD4 counts are reliably linked to HIV-associated neurocognitive impairment (Ellis et al, 2011;Hassanzadeh-Behbahani et al, 2020;Wang et al, 2020) and brain volumes (Jernigan et al, 2011), the effect sizes tend to be small. In Black PWH, global neurocognition has been linked to current CD4 cell counts (Marquine et al 2016). However, the same study found HIV RNA did not relate to neurocognition for either Black or White PWH.…”
Section: Discussionmentioning
confidence: 90%
“…A smaller number of studies have examined the effects of race among PWH. Overall, those studies tend to show that Black PWH perform below White PWH (but comparable to Hispanic PWH) on measures of verbal fluency, information processing speed, executive functions, and working memory (Cruz et al, 2020;Marquine et al, 2016;Vo et al, 2013). For example, Winston and colleagues (2013) reported that Black PWH were over seven times more likely to meet Frascati-defined (Antinori et al, 2007) criteria for neurocognitive impairment than were White PWH.…”
Section: Evidence For Neuropsychological Health Disparities In Black Americans With Hiv Diseasementioning
confidence: 99%
“…23 However, when considered in conjunction with ethnicity, VACS scores were significantly associated with deterioration of global cognition only among Non-Hispanic whites and African Americans and not among Hispanics. 24 Interestingly, in the Korean cohort, older age was associated with better cognitive function. Whilst cognitive function usually deteriorates with age, older PLWH tend to have a better virological response, likely due to better adherence, than their younger counterparts 25,26 which may explain our findings.…”
Section: Discussionmentioning
confidence: 95%