The impact of exercise intervention for patients undergoing hemodialysis on fatigue and quality of life

Abstract

Background: This study aims to determine the therapeutic efficacy of exercise interventions for patients undergoing hemodialysis (HD) on fatigue and health-related quality of life (HRQoL). Methods: This review will only include randomized controlled trials (RCTs). The search strategy will be performed in 4 English databases, 4 Chinese databases, Clinical Trials.gov, and the Chinese Clinical Trial Registry. All English or Chinese RCTs, published from inception to May 31, 2020, will be sought. Two reviewers will screen, select studies, extract data, and assess quality independently. Primary outcome is fatigue assessed by questionnaire. The methodological quality including the risk of bias of the included studies will be evaluated using the Physiotherapy Evidence Database scale. Stata 12.0 software will be used for heterogeneity assessment, generating funnel-plots, data synthesis, subgroup analysis, and sensitivity analysis. Results: We will provide some more practical and targeted results investigating the effect of exercise interventions for patients undergoing HD on fatigue and HRQoL in the current meta-analysis, and point out the main limitation of previous studies. Conclusion: The study will provide recent evidence for evaluating the therapeutic efficacy of exercise interventions for patients undergoing HD on fatigue and HRQoL. Registration number: INPLASY202050071 (DOI: 10.37766/inplasy2020.5.0071)

Quality of life tools among patients on dialysis: A systematic review

“… Functional Independence Measure (FIM) ( Matsufuji et al, 2015 ) Physical; Psychological; Social 6 Self-Care; Sphincter control; mobility; locomotion; communication; social cognition 18 Used to assess and grade a person's functional status based on the level of assistance he or she requires. FIM scores range from: 1–7, where 1 = Total dependence, and 7 = complete independence with no helper Piper Fatigue Scale (PFS) ( Zhang et al, 2020 , Reeve et al, 2012 ) Phycological; Physical; Social 4 Behavior; affect; sensory; cognitive/mood 27 22 items, each scaled using 0–10 to measure four dimensions of subjective fatigue. In addition to 5 writing questions that help to describe reasons and states.…”

“… Physical Zhang et al. (2020) ( Zhang et al, 2020 ) Systematic Review and meta -analysis Evaluation of the therapeutic efficacy of exercise for patients undergoing hemodialysis on fatigue and HRQoL. Patients with ESRD undergoing hemodialysis Inclusion Criteria: Patients with ESRD undergoing hemodialysis who were diagnosed using the Kidney Disease Improving Global Outcomes.…”

“…Five studies ( Picariello et al, 2018 , Picariello et al, 2021 , Suhardjono et al, 2019 , Matsufuji et al, 2015 , J.S. et al, 2017 , Zhang et al, 2020 ) examined the effect of non-pharmacological approaches on QoL among kidney dialysis patients. Suhardjono et al (2019) reported improved lower exterminates muscle strength following an exercise regimen ( Picariello et al, 2018 ).…”

Effect of exercise on fatigue in patients receiving maintenance hemodialysis treatment: A systematic review and network meta-analysis

“…14 To date, clinical trials have demonstrated that Baduanjin, Pilates, yoga, aerobic exercise, muscle relaxation exercise, resistance exercise, and aerobic-resistance combined exercise could improve the symptoms of fatigue in MHD patients, [15][16][17][18][19] and increase dialysis adequacy and urea clearance, 20 but are limited by sample size, lack of a control group, or short intervention duration, and the optimal exercise type and format for MHD patients remains uncertain. Several systematic reviews and meta-analyses have shown that exercise intervention could alleviate fatigue symptoms in MHD patients, [21][22][23][24] but only one specific type and time of exercise (intradialytic or interdialytic) are discussed; in addition, traditional meta-analysis cannot rank for different interventions. Meanwhile, network meta-analysis (NMA), also known as mixed treatment comparison or multiple treatments comparison meta-analysis, is a statistical method to directly and indirectly compare the effects of two or more treatments and allows the ranking of different treatments.…”

Exercise training in dialysis patients: impact on cardiovascular and skeletal muscle health

“…Recently, Zhang et al . [ 68 ] conducted a meta-analysis to define a protocol for systematic review and meta-analysis of the literature to study the therapeutic efficacy of exercise interventions for patients undergoing HD on fatigue and health-related QoL that could contribute to limit the bias due to heterogeneity of exercise protocols and outcomes.…”