The goal attached to the ongoing research is to explore the influence of geographical conditions, geographical area and information system on the economic development in Russia. The aim that is also attached with the current article is to examine the mediating impact of international relations among the nexus of geographical conditions, geographical area, information system and economic development in Russia. The study and questionnaires have followed the quantitative method of collecting data were used for this purpose. The economist and geographical planner are the respondents while smart-PLS were used to analyze the data by means of checking the reliability, validity and testing of hypotheses. The results show that geographical conditions, geographical area and information system have a positive association with economic development in Russia. The outcomes also exposed that international relations positively mediates among the links of geographical conditions, geographical area, information system and economic development in Russia. These outcomes are providing the guidelines to the regulators that they should increase their focus on the geographical conditions, area and information system factors that could enhance economic development in the country.