The Impact of Extended Typing On Red Blood Cell Alloimmunization in Transfused Patients

Makarovska-Bojadzieva, T.; Velkova, Еmilija; Blagoevska, M.

doi:10.3889/oamjms.2017.054

Cited by 18 publications

(13 citation statements)

References 16 publications

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“…Approximately half of these patients receive multiple transfusions throughout their lives, and approximately 7·5% begin a system of chronic transfusion (Zheng & Maitta, ). However, this therapy can be associated with an increased risk of hyperhemolysis, transient aplasia and erythrocyte alloimmunisation (Miller et al ., ; Kelly et al ., ; Makarovska‐Bojadzieva et al ., ).…”

mentioning

confidence: 97%

The erythrocyte alloimmunisation in patients with sickle cell anaemia: a systematic review

Gomes

Machado

Oliveira

et al. 2018

Transfusion Medicine

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Transfusion therapy is a common practice in the treatment of anaemia and can cause erythrocyte alloimmunisation. To systematise data related to erythrocyte alloimmunisation in patients with sickle cell disease (SCD). A bibliographic search was carried out in September 2017 to search for studies in four electronic databases. (i) Referring to the original work, (ii) being cohort or case-control, (iii) having been developed with individuals with SCD and (iv) having evaluated the erythrocyte alloimmunisation. Two reviewers identified the articles for inclusion in the study, extracted the predetermined data and carried out the evaluation of the methodological quality of the work. 21 studies were selected; the studies included data on 20 636 individuals (children and adults), were mostly published in the last 10 years, were developed in the United States and had high methodological quality. The occurrence of erythrocyte alloimmunisation ranged from 4·4 to 76%, and there was a higher rate of alloimmunisation against antigens of the Rh system. The risk factors for alloimmunisation were age; gender (female); red blood cell (RBC) units received; presence of ≥1 autoantibodies, TNF-α, interleukin (IL1B), human leukocyte antigens (HLA)-DRB1 gene polymorphisms; first blood transfusion (BT) after 5 years of age, transfusion episodic, multiple or during inflammatory events, acute chest syndrome (ACS) and vase-occlusive crisis (VOC); increased percentage of CD41 T memory cells; and positive direct antiglobulin test. Transfusion policies should be developed to protect the patient and his or her health based on the main factors associated with its incidence.

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confidence: 97%

The erythrocyte alloimmunisation in patients with sickle cell anaemia: a systematic review

Gomes

Machado

Oliveira

et al. 2018

Transfusion Medicine

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“…This frequency is far inferior to the one obtained in Morocco by Atouf in 2013 which was 90.4%, also in Ivory Coast carried by Sekongo in 2017 the obtained a frequency of 28.6%. This can be explained by the difference in the total population of study which was 2027 in Morocco by Atouf,42 in Ivory Coast compare to us which was 104 [5,16]. These results obtained implies that in the future, sickle cell patient will have difficulty in finding compatible blood for treatment and it is a real problem since transfusion is the major standard of care for patient suffering from sickle cell anemia in Cameroon.…”

Section: Discussionmentioning

confidence: 73%

Frequency of Allo-Immunization in Sickle Cell Disease: Case of the Patients at the Laquintinie Hospital in Douala-Cameroon

Guegang¹,

Tuono²,

Fewou³

et al. 2022

EJCBS

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Background: Allo-immunization is an immune response to foreign antigens after exposure to genetically different cells or tissues. Allo-immunized patients with sickle cell disease (SCD) appear to experience worse survival compared to non allo-immunized patients. Therefore, to contribute to the management of patients living with SCD and improve the blood transfusion process, we aimed to determine the frequency of allo-immunization in SCD's patients. To realize this study, we carry out a cross sectional study in one Hospital of Douala-Cameroon. Method: Plasma was prepared from collected blood sample, electrophoresis was done and depending on the migration on the gel; the type of electrophoresis was determine. Blood group ABO/Rh was done. After electrophoresis, depending on the result obtained those that was not homozygote (SS) and heterozygote sickle cell anemia (AS) was discarded. The check for irregular agglutinins was done using the indirect Coombs test. Clinical and biological characteristics of the different participants were studied and analyzed using a Statview statistical software. Result: We obtained 104 sickle cell patient, out of these we had 55% of positive RAI, with an average transfusion of 7.35. Also 83 patients were homozygote sickle cell anemia for a mean age of 15.75 years old (ranging from 1 to 52 years). The result obtained shows that the number of blood transfusion for homozygote sickle cell patient increases with age and that homozygote sickle cell patient received more blood transfusion than heterozygote patient. It can also be said that allo-immunization in these patients originate from the multiple blood transfusion received that were not fully compatible and that it affects more children (from 1 -15), they accounted for about 53.85% of the total population. Our result obtained implies that in the future, sickle cell patient will have difficulty in finding compatible blood for treatment and is a real problem since transfusion is the major standard of care for patient suffering from sickle cell anemia in Cameroon. The absence of treatment may lead to the death of the patient. To help reduced allo-immunization, extended compatibility test in all the red blood cell system and routinely screening for the presence of irregulars agglutinins may reduce the frequency of allo-immunization.

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“…Shah et al and Setya et al reported similar results of the frequencies [24,25]. However, Makarovska-Bojadzieva et al from the Republic of Macedonia reported different results with low frequencies of both Jka and Jkb at 7.7% and 2.5% respectively [26].…”

Section: Discussionmentioning

confidence: 82%

Frequency of Extended Red Cell Antigen Phenotype Among Patients of Hematological Diseases: A Single Center Study

Tariq¹,

Ahmed²,

Ashfaq³

et al. 2022

Cureus

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BackgroundAlloimmunization of erythrocytes is a major problem in patients with hematological diseases that require frequent blood transfusions. Matching of extended red cell antigens of Kell, MNS, Kidd, and Duffy can decrease the risk of alloimmunization. Hence, in this study, the frequencies of the extended red cell phenotypes were explored. ObjectiveTo find out the frequency of extended red blood cell antigen phenotypes among patients with hematological diseases. MethodsThis cross-sectional research study was performed on 488 patients diagnosed with hematological diseases who required blood transfusion at the National Institute of Blood Disease and Bone Marrow Transplantation Karachi for a period of 1.42 years from November 2019 to March 2021. The blood of patients was analyzed for antigen phenotypes of different blood group systems including Kell, MNS, Kidd, and Duffy. The data obtained were interpreted. ResultsAmong the 488 patients, 284 (58.20%) patients were male, and 204 (41.80%) patients were female with a mean age of 8.1 years. Beta thalassemia was the most common hematological disease reported in 354 (72.5%) of the patients. The most common blood group was O positive reported in 182 (37.3%) of the patients followed by B positive blood group in 124 (25.4%). The frequencies of extended red cell antigen phenotypes in the patients were K antigen 14 (2.9%), Kp a antigen 26 (5.3%), Kp b antigen 424 (86.9%), Fy a antigen 360 (73.8%), Fy b antigen 260 (53.3%), Jk a antigen 294 (60.2%), Jk b antigen 326 (66.8%), M antigen 410 (84.0%) and N antigen 306 (62.7%). ConclusionBeta thalassemia was the most common hematological disease followed by iron deficiency anemia, aplastic anemia, and acute leukemia. Patients with hematological diseases had a higher prevalence of Kp b antigen followed by M, Fy a , Jk b , N, Jk a , Fy b , Kp a, and K antigen. O positive was the most frequent blood group followed by B positive, A positive and AB positive blood group.

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The Impact of Extended Typing On Red Blood Cell Alloimmunization in Transfused Patients

Cited by 18 publications

References 16 publications

The erythrocyte alloimmunisation in patients with sickle cell anaemia: a systematic review

The erythrocyte alloimmunisation in patients with sickle cell anaemia: a systematic review

Frequency of Allo-Immunization in Sickle Cell Disease: Case of the Patients at the Laquintinie Hospital in Douala-Cameroon

Frequency of Extended Red Cell Antigen Phenotype Among Patients of Hematological Diseases: A Single Center Study

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