The Impact of Extreme Maternal Ages on Hypertensive Disorders of Pregnancy: A Retrospective Cohort Study in Dakar, Senegal

Ndiaye, Mame Diarra; Gueye, Mamour; Diallo, Moussa; Wade, Malick; Diakhate, Abdoulaye; Diouf, Abdoulaye; Niang, Ndama; Ndour, Simon Birame; Fall, Ndeye Gothe; Mbaye, Magatte; Moreau, Jean Charles

doi:10.4236/ojog.2020.1020018

Cited by 2 publications

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“…Some authors link placental laterality and the high risk of hypertension in pregnant women [35,36], which also coincides with our findings. The development of eclampsia can also be associated with adolescence, and age over 35 years -with hypertension [28]. Thus, our work clearly shows the risk factors and presents a screening model for PE.…”

Section: Discussionmentioning

confidence: 53%

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The model of screening for preeclampsia in the second and third trimesters of gestation

et al. 2023

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Purpose: Preeclampsia (PE) is a specific syndrome of multiple organ insufficiency in case of pregnancy, which is included in the panel of major obstetric syndromes and is among the main causes of maternal morbidity and mortality in the whole world. Material and methods: We conducted a prospective cohort study of 91 pregnant women to evaluate the effectiveness of integrated use of maternal risk factors (2019 International Federation of Gynecology and Obstetrics recommendations), placenta location (ultrasound at 18-20 weeks of gestation), and serum cystatin C (at 18-36 weeks of gestation) in screening for pe in the second and third trimesters of gestation. Results: In the subgroup of pregnant women with cystatin C levels greater than 1.0 mg/L (27 women), PE developed in 26 women, which is 96.29% in percentage terms. When calculating GFR for cystatin C in a group with PE there was a significant violation of the renal filtration system -52.46±2.08 (95% CI, 48.39-56.54), while in healthy group the indicator is within normal limits -97.6±1.64 (95% CI, 94.38-100.82). In the analysis of the ratio of cystatin C levels more than 1.0 mg / l and the development of PE, a sensitivity of 98.46%, specificity of 100% and accuracy of 98.9%, p<0.001. Conclusions: The data show that the combined model of maternal factors, ultrasound of the placenta and serum cystatin C, is prognostically effective in pregnant women in the second and third trimesters of gestation and is a reliable marker for the development of pe.

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Section: Discussionmentioning

confidence: 53%

“…Numerous scientific studies have concluded that older age (35 years) and an increase in BMI before pregnancy (25 kg/m 2 ) are considered moderate risk factors for PE [25][26][27][28][29][30][31]. A high rate of PE is associated with the study selection of pregnant women with maternal risk factors according to FIGO recommendations [5].…”

Section: Discussionmentioning

confidence: 99%

The model of screening for preeclampsia in the second and third trimesters of gestation

et al. 2023

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Maternal factors of pre-eclampsia development

Berlinska

Марічереда

Holubenko

et al. 2021

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Study objective: to determine the most important maternal factors for the pre-eclampsia (PE) prediction, which are used in screening of women when registered for pregnancy.Materials and methods. A prospective cohort study included 91 pregnant women in their first trimester; study period 2018–2020. The main group included 56 (61.54%) women with a number of maternal factors for PE development, and 35 (38.46%) were healthy females in the control group. Subgroups of women formed for females with and without PE – 28.57% and 71.43%, respectively.Results. Statistically significant values in the study of maternal factors were observed between subgroups of patients with and without PE for body mass index (BMI) prior to pregnancy (26.83 ± 1.29 and 26.03 ± 1.05) and height of pregnant women (163.35 ± 1.26 cm and 167.23 ± 1.02 cm), p <0.05. Among the risk factors that led to PE, statistically significant results were observed when combining the first pregnancy with a history of kidney disease (p = 0.033). Recurrent PE was observed when combined with PE history in mother (p = 0.011). Impact of chronic hypertension on the PE development was noted when the disease history was over 5 years. The combination of interval between pregnancies of 10 years and more and age >35 years was associated with PE (p = 0.008).During IVF PE developed in combination with such factors as BMI 30 kg/m2 and the interval between pregnancies over 10 years, 1.1% females had no other factors. History of renal disease and the age >35 years had an impact on the PE development in patients with anti-phospholipid syndrome. Analysis of the odds ratio of the isolated maternal factor showed the following indicators: PE during previous pregnancy – 6, multiple pregnancy – 2.56, anti-phospholipid syndrome – 2.56, first pregnancy – 1.83, in vitro fertilization – 1.72, obesity >30 kg/m2 – 1.65, PE in the mother – 1.57, age >35 years – 1.08, history of renal disease – 1, interval between pregnancies >10 years – 0.77 and chronic hypertension – 0.18.Conclusion. Thorough monitoring of maternal risk factors for PE should focus on PE during previous pregnancy. The second position is occupied by multiple pregnancy and anti-phospholipid syndrome. PE risk is increased for a combination of factors, especially with chronic renal disease and/or elevated BMI.

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The Impact of Extreme Maternal Ages on Hypertensive Disorders of Pregnancy: A Retrospective Cohort Study in Dakar, Senegal

Cited by 2 publications

References 15 publications

The model of screening for preeclampsia in the second and third trimesters of gestation

The model of screening for preeclampsia in the second and third trimesters of gestation

Maternal factors of pre-eclampsia development

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