The impact of far-UVC radiation (200–230 nm) on pathogens, cells, skin, and eyes – a collection and analysis of a hundred years of data

Heßling, Martin; Haag, Robin; Sieber, Nicole; Vatter, Petra

doi:10.3205/dgkh000378

Cited by 38 publications

(39 citation statements)

References 78 publications

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“…50 mJ/cm 2 is somewhat higher but in a range similar to that of the UVC dose, although far-UVC-D90 data does not yet exist for some microorganisms, including the relevant micrococci. However, this ratio between UVC and far-UVC doses for the selected microorganisms is also in agreement with our previous study, which included a larger number of microorganisms [ 30 ].…”

Section: Discussionsupporting

confidence: 92%

“…However, within UVC. there is the spectral range of 200–230 nm, called far-UVC, which is assumed to be similarly effective as the 254 nm UVC radiation of the widely applied mercury vapor lamps, but poses a much lower risk to humans [ 29 ], [ 30 ]. Unfortunately, suitable radiation sources are still difficult to obtain and many properties of far-UVC have not yet been sufficiently investigated.…”

Section: Introductionmentioning

confidence: 99%

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Review of microbial touchscreen contamination for the determination of reasonable ultraviolet disinfection doses

Heßling

Haag

Sicks

2021

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Background: Touchscreens are usually microbially contaminated and can therefore act as fomites inside and outside healthcare environments. Due to the increasing use of such touchscreens and the growing awareness of infection risks, approaches that allow safe and automatic disinfection are desired. Ultraviolet (UV) irradiation, with its known antimicrobial efficacy, could achieve this goal, but should be executed with limited touchscreen degradation, disinfection duration, and energy consumption. It should also pose as little harm as possible to humans even in case of failure. Materials and methods: A literature search was performed first to identify the microorganisms most commonly found on touchscreens. Then, the 90% reduction doses (D90 doses) for the different relevant microorganisms and UV spectral ranges were determined from the literature, and irradiation doses are suggested that should reduce most of these important microorganisms by 5 log-levels. Results: The most frequent microorganisms are staphylococci, bacilli, micrococci, enterococci, pseudomonads and E. coli with small differences between hospital and community environments, if antibiotic resistance properties are ignored. The determined irradiation doses for a 5 log-reduction of the most frequent microorganisms are about 40 mJ/cm 2 , 80 J/cm 2 , 500 J/cm 2 and 50 mJ/cm 2 for the UV spectral ranges UVC, UVB, UVA and far-UVC, respectively. These doses are also sufficient to inactivate all nosocomial ESKAPE pathogens on touchscreens by at least 99.999%. Conclusion: Disinfection is achievable in all UV spectral ranges, with UVC being the most effective, enabling automatic disinfection within a minute or less. The much higher doses required in the UVB and UVA spectral range result in much longer disinfection durations, with the advantage of a reduced risk to humans. For all kinds of UV irradiation, the doses should be limited to reasonable values to avoid irradiating an already more or less sterile surface and to prevent degradation of touchscreen devices.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Review of microbial touchscreen contamination for the determination of reasonable ultraviolet disinfection doses

Heßling

Haag

Sicks

2021

Self Cite

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“…Input information into the UV222 TM software contained data on distance to nearest unprotected eye, maximum occupancy time per patient or staff, and dose delivered (dd) per onoff cycle in the farthest distance from the lamp. In this instance, dd for chair seats were 400µJ, which is the approximate equivalence of the dose needed to reduce infectivity of SARS-CoVid-2 approximately 90% 7,15 .…”

Section: Filtered 222nm Excimer Lampmentioning

confidence: 89%

“…Searches for a tolerable technique has led to the development of the excimer lamp that generates UV light at 222 nm, a wavelength safe to humans. Most studies published on the antimicrobial e ciency of UV at 222 nm have been performed in laboratory settings as proof of principle 15 . While results have been very positive with regards to both human safety and in-vitro antimicrobial effect, this study is the rst to show e cacy in a real-life setting and nds two interesting results.…”

Section: Discussionmentioning

confidence: 99%

“…This due to all patients testing negative before visits. However, viruses, including SARS-CoVid-2 are more easily eliminated by 222nm UVC-Light than bacteria 15 and is therefore reasonable to assume that ltered 222nm excimer lamps would inactivate these viruses in this setting as well. A limitation to 222nm UVC-Light technology is that it only exert its effect on surfaces that are exposed and thus not on shadowed areas.…”

Section: Discussionmentioning

confidence: 99%

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Anti-microbial effect of filtered 222nm excimer lamps in a hospital waiting area

Thyrsted

Skaarup

Hvass

et al. 2022

Preprint

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Hospital aquired infections is a considerable challenge for vulnerable patients. Traditional anti-microbial mercury lamps emit light at 254nm and have well established anti-microbial effects. Their use in populated areas is, however, hindered by their carcinogenic properties. This is in contrast to anti-microbial lamps based on krypton chloride (KrCl), demonstrated to have no carcinogenic potential. These lamps emit light with a peak intensity at 222nm and have broad bactericidal and viricidal effects including inactivation of SARS-CoVid-2 in laboratory experiments. Here, we investigate the bactericidal effects of filtered KrCl 222nm excimer lamps (UV222 TM lamps) in an out-patient waiting area at the pulmonology clinic at Aarhus University Hospital. Furniture sufaces were sampled for bacterial load in a single-arm interventional longitudinal study with and without exposure to filtered 222nm UVC-light. Furthermore, bacterial species were identified using MALDI-ToF mass-spectrometry. We found filtered 222nm UVC-light to significantly reduced the number of colony-forming-units. Pathogenic bacteria such as Staphylococcus aureus and Staphylococcus epidermidis were detected only in the non-exposed areas suggesting that these species in particular are highly sensitive to inactivation by 222nm UVC-light. This study demonstrates the potential use of 222nm Far-UVC technology to reduce bacterial load and thus the spread of infectious disease in a hospital setting.

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UV Protection and Antimicrobial Properties of Textiles Using Nanotechnology

Ahmed,

Mazumdar,

Syduzzaman

et al. 2024

Materials Horizons: From Nature to Nanomaterials

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The impact of far-UVC radiation (200–230 nm) on pathogens, cells, skin, and eyes – a collection and analysis of a hundred years of data

Cited by 38 publications

References 78 publications

Review of microbial touchscreen contamination for the determination of reasonable ultraviolet disinfection doses

Review of microbial touchscreen contamination for the determination of reasonable ultraviolet disinfection doses

Anti-microbial effect of filtered 222nm excimer lamps in a hospital waiting area

UV Protection and Antimicrobial Properties of Textiles Using Nanotechnology

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