The impact of fish oil and wheat germ oil combination on mineral-bone and inflammatory markers in maintenance hemodialysis patients: a randomized, double-blind, placebo-controlled clinical trial

Zakaria, Hadeer; Mostafa, Tarek; El-Azab, Gamal A.; Wahab, Ahmed M. Abd El; Elshahawy, Heba; Sayed‐Ahmed, Nagy

doi:10.1007/s11255-017-1643-6

Cited by 14 publications

(16 citation statements)

References 33 publications

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“…In the eligibility section, six articles were eliminated that did not evaluate whether the studies were non-randomized trials or described a diseased population (Haripriya and Premakumari, 2010 ; Zakaria et al, 2017 ). One study was also removed that did not report the functionality of wheat germ related to metabolic markers (Kobyliak et al, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

Effect of wheat germ on metabolic markers: a systematic review and meta-analysis of randomized controlled trials

Liaqat

Jeong

Kim

et al. 2020

Food Sci Biotechnol

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This systematic review and meta-analysis aim to evaluate the association of wheat germ interventions and metabolic markers. An electronic search was performed by mid-May 2019 in the PubMed, Google Scholar, and Web of Science databases. Quality was evaluated using the risk of bias assessment tools. Thirty-three randomized controlled trials (RCTs) were identified, among which ten were suitable and systematically reviewed based on biomarkers (cholesterol, triglycerides, glucose, and oxidative stress). Three biomarkers in five eligible studies were investigated by meta-analysis. Total cholesterol showed non-significant results (p = 0.98), with standard mean difference (SMD) of-0.01 (95% confidence interval;-0.17, 0.16). The SMD was-0.06 (95% CI-0.41, 0.29, n = 4) for triglycerides and-0.09 (95% CI-0.62, 0.45, n = 2) for glucose. No biomarkers showed heterogeneity (0%). This review revealed non-significant association between wheat germ interventions and metabolic markers. Sensitive analysis with high-quality RCTs may be worth trying.

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Section: Resultsmentioning

confidence: 99%

Effect of wheat germ on metabolic markers: a systematic review and meta-analysis of randomized controlled trials

Liaqat

Jeong

Kim

et al. 2020

Food Sci Biotechnol

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“…Six trials provided data on hs-CRP among the five treatments ( n = 303) (Figure 2B) [10,11,20,25,28,30]. According to the available data, our network meta-analysis of hs-CRP showed no significant differences among placebo, PUFA, vitamin E, PUFAs plus vitamin E, and MCT (Supplementary File 4).…”

Section: Resultsmentioning

confidence: 98%

“…Then, two systematic reviews and 25 randomized clinical trials without relevant outcomes were excluded [31,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69]. There were 21 references from 18 RCTs meeting the eligibility criteria (Figure 1) [10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30].…”

Section: Resultsmentioning

confidence: 99%

“…The 18 trials recruited 962 patient undergoing dialysis from Brazil [24], Denmark [13,18], Greece [27], Egypt [30], Iran [10,14,21,22,25,26], Korea [23], United States [11,12,19,20,29], and Sweden [28]. The treatments in the 18 trials could be categorized into five treating strategies including placebo, PUFAs, vitamin E, medium chain triglyceride (MCT), and PUFAs plus vitamin E. The available data in each study showed mean ages from 46.4 to 68 years old, and a total of 598 (62.2%) men were included in the studies.…”

Section: Resultsmentioning

confidence: 99%

“…To improve the outcomes among patients with hemodialysis, controlling their inflammatory status is an important aspect in clinical practice. In the past decade, many trials have tried to control these inflammations among this group of patients through nutrient supplements [10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30]. Commonly-used nutrient supplements such as polyunsaturated fatty acids (PUFAs), vitamin D, antioxidants, polyphenol-rich foods, fibers, and probiotics to modulate patient’s immune response are becoming more and more popular [31].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy of Polyunsaturated Fatty Acids on Inflammatory Markers in Patients Undergoing Dialysis: A Systematic Review with Network Meta-Analysis of Randomized Clinical Trials

Yeh

et al. 2019

IJMS

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The effects of polyunsaturated fatty acids (PUFAs) on inflammatory markers among patients receiving dialysis have been discussed for a long time, but previous syntheses made controversial conclusion because of highly conceptual heterogeneity in their synthesis. Thus, to further understanding of this topic, we comprehensively gathered relevant randomized clinical trials (RCTs) before April 2019, and two authors independently extracted data of C-reactive protein (CRP), high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) for conducting network meta-analysis. Eighteen eligible RCTs with 962 patients undergoing dialysis were included in our study. The result showed that with placebo as the reference, PUFAs was the only treatment showing significantly lower CRP (weighted mean difference (WMD): −0.37, 95% confidence interval (CI): −0.07 to −0.68), but the CRP in PUFAs group was not significantly lower than vitamin E, PUFAs plus vitamin E, or medium-chain triglyceride. Although no significant changes were noted for hs-CRP and IL-6 levels, PUFAs showed the best ranking among treatments according to surface under the cumulative ranking. Therefore, PUFAs could be a protective option for patients receiving dialysis in clinical practice.

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Wheat germ improves hepatic steatosis, hepatic enzymes, and metabolic and inflammatory parameters in patients with nonalcoholic fatty liver disease: A randomized, placebo‐controlled, double‐blind clinical trial

Salehi‐Sahlabadi

Kord‐Varkaneh

Kocaadam-Bozkurt

et al. 2022

Phytotherapy Research

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Globally, Non‐alcoholic fatty liver disease (NAFLD) has a rising prevalence with no definitive pharmacological treatments. The aim of this study was to assess the clinical effects of wheat germ in patients with NAFLD. Fifty participants with NAFLD were randomly allocated to take 40 g wheat germ (n = 25) or placebo (n = 25) in a randomized double‐blind clinical trial over 12 weeks. Transient elastography (FibroScan) determined a diagnosis of NAFLD. After 12 weeks of intervention, reduction in serum alanine aminotransferase (p = 0.006) and γ‐glutamyltransferase (p = 0.004), total cholesterol (p = 0.018), triglyceride (p = 0.046), and hepatic steatosis (p = 0.043) levels in the wheat germ group was significantly higher compared to the placebo group. Serum TAC levels in wheat germ group patients increased significantly higher than placebo group (p = 0.001). Reduction in serum hs‐CRP level in the wheat germ group was significantly higher than in the placebo group (p = 0.031). In conclusion, our study shows that wheat germ consumption may improve total antioxidant capacity, hepatic steatosis, serum total cholesterol and triglyceride levels, alanine aminotransferase (ALT), and Gamma‐glutamyl Transferase (GGT) in NAFLD patients. Longitudinal studies with larger sample sizes are needed to confirm biological effects of wheat germ on NAFLD patients.

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The impact of fish oil and wheat germ oil combination on mineral-bone and inflammatory markers in maintenance hemodialysis patients: a randomized, double-blind, placebo-controlled clinical trial

Abstract: FO plus WGO supplementation showed beneficial effect on serum Ca levels of HD patients without any statistically significant effect on other mineral-bone and inflammatory markers. Further investigations are required to confirm it.

Cited by 14 publications

References 33 publications

Effect of wheat germ on metabolic markers: a systematic review and meta-analysis of randomized controlled trials

Effect of wheat germ on metabolic markers: a systematic review and meta-analysis of randomized controlled trials

Efficacy of Polyunsaturated Fatty Acids on Inflammatory Markers in Patients Undergoing Dialysis: A Systematic Review with Network Meta-Analysis of Randomized Clinical Trials

Wheat germ improves hepatic steatosis, hepatic enzymes, and metabolic and inflammatory parameters in patients with nonalcoholic fatty liver disease: A randomized, placebo‐controlled, double‐blind clinical trial

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