The impact of gender, age, race/ethnicity, and stage on quality of life in a spectrum of cutaneous lymphomas

Martínez, X.; Chowdhury, Arnab; Stiller, Tracey; Palmer, Joycelynne; Loscalzo, Matthew; Barrios, Estella; Abdulla, Farah; Zain, Jasmine; Rosen, Steven T.; Querfeld, Christiane

doi:10.1007/s00520-021-06241-6

Cited by 9 publications

(13 citation statements)

References 33 publications

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“…5,22 To date, HRQoL in CBCL patients was merely investigated in mixed PCL cohorts together with CTCL patients. [24][25][26][27] We compared our study population to historic samples from Porkert et al and Sampogna et al, who both investigated HRQoL in CBCL patients using the Skindex-29 questionnaire. 24,27 Besides CTCL patients, Sampogna et al included 24 CBCL patients in their study (4% 'severe' or 'very severe' disease course).…”

Section: Discussionmentioning

confidence: 99%

“…5 Currently, HRQoL in CBCL patients has only been studied in small-sized studies without analysis of the respective CBCL subtypes. [24][25][26][27] However, specific influencing factors on HRQoL in CBCL have not yet been identified. [24][25][26][27] In the present study, HRQoL and potential influencing factors are assessed both for CBCL in general and individually for the entities PCMZL, PCFCL and DLBCL as subgroups.…”

Section: Introductionmentioning

confidence: 99%

“…[24][25][26][27] However, specific influencing factors on HRQoL in CBCL have not yet been identified. [24][25][26][27] In the present study, HRQoL and potential influencing factors are assessed both for CBCL in general and individually for the entities PCMZL, PCFCL and DLBCL as subgroups. Thereby we aim to identify relevant parameters of HRQoL in CBCL patients which may aid to improve therapeutic management and HRQoL in CBCL patients.…”

Section: Introductionmentioning

confidence: 99%

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Health‐related quality of life and its influencing factors in patients with primary cutaneous B‐cell lymphomas: A multicentric study in 100 patients

Schirren,

Albrecht,

Melchers

et al. 2024

Acad Dermatol Venereol

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BackgroundPrimary cutaneous B‐cell lymphomas (CBCL) are a group of rare malignant skin diseases that represent approximately 20%–30% of all primary cutaneous lymphomas (PCL). Previous studies revealed impaired health‐related quality of life (HRQoL) in patients diagnosed with primary cutaneous T‐cell lymphoma (CTCL). Currently, only small‐sized studies investigated HRQoL in CBCL patients and lacked detailed analysis of respective subtypes.ObjectivesThis study aims to investigate HRQoL in CBCL patients to identify independent factors of HRQoL impairment in CBCL patients.MethodsOne hundred CBCL patients were recruited from eight German PCL centres in this multicentric, cross‐sectional study from 2021 to 2022. The patients completed the dermatologic HRQoL questionnaire Skindex‐29 and an investigator‐designed ‘CBCL‐Questionnaire’ with additional questions on HRQoL and clinical characteristics.ResultsThe Skindex‐29 revealed that HRQoL in CBCL patients is impaired on a mild to moderate level. The multiple regression analysis identified parameters like worries about dying, feeling prejudiced/discriminated and impairment of daily activities to be independently associated with impairment of HRQoL. Highest scores for HRQoL impairment were found in patients with primary cutaneous follicle centre lymphoma while on rituximab treatment and in patients with primary cutaneous marginal zone lymphoma while on watchful waiting.ConclusionsHRQoL is impaired in CBCL patients, even though, in the face of indolent disease course and favourable prognosis in the majority of cases. Of note, our investigator‐designed tool identified worries about dying, feeling prejudiced/discriminated, and the type of treatment to have a negative impact on patients' HRQoL. Our study highlights the importance of a thorough patient–doctor communication to capture overall disease burden because generic HRQoL tools might lack of disease‐specific items.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Health‐related quality of life and its influencing factors in patients with primary cutaneous B‐cell lymphomas: A multicentric study in 100 patients

Schirren,

Albrecht,

Melchers

et al. 2024

Acad Dermatol Venereol

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“…A recent study shows that patients with Sézary syndrome suffer more than those with MF. In addition, other factors associated with a low quality of life are a high LDH index, high mSWAT index, alopecia, dark skin, and female gender 19,20 . Shinoara 21 and colleagues show that patients with a manifestation of the disease in the head and neck area, genitals, hands and feets show a greater suffering.…”

Section: Quality Of Lifementioning

confidence: 99%

Cutaneous T‐cell lymphoma—Focus on some problems, and some solutions

Beltraminelli

2023

Hematological Oncology

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Cutaneous lymphomas are a heterogeneous group of several distinct entities of lymphoproliferative diseases. The diagnosis of a cutaneous lymphoma is a challenge, and it is always the result of a careful analysis of several information's consisting of clinical history, clinical picture, histological and molecular analyses. For this reason, experts taking care of patients with a skin lymphoma need to know all the peculiar diagnostic elements very well, in order not to run into mistakes. In this article, we will focus the discussion on some issues as the skin biopsy (when and where). In addition, we will discuss the approach to the erythrodermic patient, whose differential diagnoses include mycosis fungoides, and Sézary syndrome, beside more frequent inflammatory conditions. Finally, we will address the issue of quality of life and the possible support of the suffering patient with a cutaneous lymphoma, well knowing that the current therapeutic possibilities are unfortunately limited.

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“…Although MF is found in patients of all skin types, MF is often diagnosed at an advanced stage in patients with skin of color and results in worse outcomes with limited treatment options (Nath et al, 2014). Early identification of MF in patients with skin of color could result in improved quality of life and address the higher incidence of advanced-stage MF in these populations (Martinez et al, 2021).…”

mentioning

confidence: 99%

Mycosis Fungoides in Skin of Color

Rager

Lake

2022

Journal of the Dermatology Nurses' Association

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Mycosis fungoides is the most common primary cutaneous T-cell lymphoma. Although mycosis fungoides affects patients of all skin tones, mycosis fungoides has a higher incidence in patients with skin of color. Patients with skin of color who are diagnosed with mycosis fungoides have worse outcomes and poor prognosis compared with patients with lighter skin tones. Mycosis fungoides is difficult to diagnose in patients with skin of color as rare subtypes or clinical presentations are commonly seen in these populations. Increased awareness of the presentation of mycosis fungoides in skin of color and early detection could address the higher rates of morbidity and mortality in these populations.

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The impact of gender, age, race/ethnicity, and stage on quality of life in a spectrum of cutaneous lymphomas

Cited by 9 publications

References 33 publications

Health‐related quality of life and its influencing factors in patients with primary cutaneous B‐cell lymphomas: A multicentric study in 100 patients

Health‐related quality of life and its influencing factors in patients with primary cutaneous B‐cell lymphomas: A multicentric study in 100 patients

Cutaneous T‐cell lymphoma—Focus on some problems, and some solutions

Mycosis Fungoides in Skin of Color

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