250Text: 3998 2 Abstract Purpose: Patient Reported Outcomes (PROs) have become essential clinical trial end points. However, a comprehensive, multi-dimensional, patient-relevant and precise glaucoma-specific PRO instrument is not available. Therefore, the purpose of this study was to identify content for a new, glaucoma-specific, quality of life (QOL) item bank. Results: A total of 737 unique items (extant items from PRO instruments, 247; qualitative articles, 14 items; focus groups and semi-structured interviews, 476 items) were identified. These items were classified into 10 QOL domains. Four criteria (item redundancy, item inconsistent with domain definition, item content too narrow to have wider applicability, and item clarity) were used to remove and refine the items. After the cognitive interviews, the final minimally representative item-set had a total of 342 unique items belonging to
Methods
Conclusion:The systematic content identification process identified ten QOL domains which were important to patients with glaucoma. The majority of items were identified from the patient-specific focus groups and semi-structured interviews suggesting that the existing PRO instruments do not adequately address QOL issues relevant to individuals with glaucoma.