The Impact Of Glubran 2 Use As A Biliostatic and Hemostatic Agent During Liver Resection In Pediatric Patients 

Abstract

Background Pediatric liver resection presents unique challenges, particularly in achieving effective hemostasis and biliostasis. Glubran 2, a synthetic surgical adhesive material composed primarily of modified n-butyl-2-cyanoacrylate, has shown a promise in various surgical applications. This study aimed to evaluate the impact of Glubran 2 application on alleviation of postoperative complications in pediatric liver resections. Methods This retrospective study was conducted on 22 pediatric patients underwent liver resection, those receiving intraoperative Glubran 2 on the transected liver surface. the current research was planned to investigate the mitigating action of glubran 2 on the hepatic resection related biliary leakage and bleeding . Results The mean age was 3.1 years (± 3.15). Hepatoblastoma was the most common pathology (50%). Right hepatectomy was performed in 59.09% of cases. Following the application of Glubran, postoperative biliary leakage showed no effect when compared with the results in literature, occurring in 18.18% of patients, with varying degrees of severity. however, the incidence of postoperative bleeding was markedly improved, observed in just 5.26% of patients. The mean hospital stay was 11.6 days (± 4.94), ranging from 3 to 22 days. Conclusions This study highlights the use of a hemostatic and a biliostatic agent like Glubran 2 that may potentially impact the outcome after liver resection in pediatric patients regarding bleeding.