The impact of grape proanthocyanidin extract on dexamethasone-induced osteoporosis and electrolyte imbalance

Hasona, Nabil A.; Morsi, Abdullah; Alghabban, Abdullah Ali

doi:10.1007/s00580-018-2724-3

Cited by 3 publications

(6 citation statements)

References 47 publications

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“…Twenty-six studies revealed the potential effect of GSE on the alveolar bone, including maxilla, 15 interpremaxillary, 34 alveolar bone in a molar area, 35 36 37 and incisive area 38 39 the mandibular jaw bone 40 41 and condyle 31 42 skeletal bone including the femur, 28 43 calvaria, 28 and tibia. 28 44 45 46 47 In the disease model, femur, 48 49 50 51 52 tibia, 53 54 and knee were used. 55 56…”

Section: Resultsmentioning

confidence: 99%

“…The study of supplementations of GSE was mostly performed in Wistar rats, 15 31 35 36 37 38 40 41 42 43 44 45 46 47 49 50 54 55 Sprague-Dawley rat, 34 rabbits, 39 51 52 and mice. 28 48 56…”

Section: Resultsmentioning

confidence: 99%

“…GSE supplementation was performed in some studies related to bone healing-related disease. The in vivo model was performed by LPS to induce inflammation model, 48 osteoporosis, 49 50 osteonecrosis, 51 52 and arthritis. 53 54 55 56 In the bone inflammation and osteoporosis model, GSE maintained the bone structure, 49 by increasing the trabecular thickness 48 50 and bone mineral content.…”

Section: Discussionmentioning

confidence: 99%

“…Twenty-six studies revealed the potential effect of GSE on the alveolar bone, including maxilla, 15 interpremaxillary, 34 alveolar bone in a molar area, [35][36][37] and incisive area 38,39 the mandibular jaw bone 40,41 and condyle 31,42 skeletal bone including the femur, 28,43 calvaria, 28 and tibia. 28,[44][45][46][47] In the disease model, femur, [48][49][50][51][52] tibia, 53,54 and knee were used. 55,56 The study of supplementations of GSE was mostly performed in Wistar rats, 15,31,[35][36][37][38][40][41][42][43][44][45][46][47]49,50,54,55 Sprague-Dawley rat, 34 rabbits, 39,51,52 and mice.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…28,[44][45][46][47] In the disease model, femur, [48][49][50][51][52] tibia, 53,54 and knee were used. 55,56 The study of supplementations of GSE was mostly performed in Wistar rats, 15,31,[35][36][37][38][40][41][42][43][44][45][46][47]49,50,54,55 Sprague-Dawley rat, 34 rabbits, 39,51,52 and mice. 28,48,56 The GSE Effect on Alveolar Bone…”

Section: Study Characteristicsmentioning

confidence: 99%

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The Effect of Grape Seed Extract on the Alveolar, Jaw, and Skeletal Bone Remodeling: A Scoping Review

et al. 2023

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Herbal medicine has an important part in promoting and maintaining human health. One of them was grape seed extract (GSE). Various potentials of GSE in human health have been explored, and its potential for maintaining bone health is promising. Some initial research has provided evidence that the GSE was able to affect bone remodeling (bone resorption and bone formation). This scoping review analyzed and discussed all the reports on the effect of GSE on bone healing and bone remodeling in animals in the alveolar bone, jaw bone, and skeletal bone. The further purpose is to give an opportunity to research and development of supplementation of GSE for humans.The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines were used to compose this scoping review through database on Scopus, PubMed, Science Direct, Web of Science, Embase, and manual search until December 2022. The inclusion criteria were a study that analyzed the effect of supplementation GSE on all bones.All included study was in vivo study with supplementation of GSE. The supplementation of GSE affects the alveolar bone, jaw bones, and skeletal bone by promoting bone formation and inhibiting bone resorption by suppressing inflammation, apoptosis pathways, and osteoclastogenesis. It not only supports bone remodeling in bone inflammation, osteonecrosis, osteoporosis, and arthritis but also the GSE increases bone health by increasing the density and mineral deposition in trabecula and cortical bone.The supplementation of GSE supports bone remodeling by interfering with the inflammation process and bone formation not only by preventing bone resorption but also by maintaining bone density.

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Section: Resultsmentioning

confidence: 99%

“…The study of supplementations of GSE was mostly performed in Wistar rats, 15 31 35 36 37 38 40 41 42 43 44 45 46 47 49 50 54 55 Sprague-Dawley rat, 34 rabbits, 39 51 52 and mice. 28 48 56…”

Section: Resultsmentioning

confidence: 99%