The impact of HCV eradication on hyperglycemia, insulin resistance, cytokine production, and insulin receptor substrate-1 and 2 expression in patients with HCV infection

Mahmoud, Basant; Abdel-Moneim, Adel; Mabrouk, Doaa

doi:10.1007/s10238-021-00773-1

Cited by 5 publications

(3 citation statements)

References 47 publications

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“…Conversely, higher fibrosis stage before treatment, longer T2DM duration, a positive family history of diabetes, the Child class B, and the oesophageal varices were associated with lower improvement of glycemic control 75,78,85,87 . Viral eradication seems to have the greater impact on the improvement of both HbA1c and HOMA‐IR in diabetic patients, whereas in prediabetic patients it is related only with the reduction of HbA1c 63,88 …”

Section: Resultsmentioning

confidence: 99%

Effect of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, and associated metabolic comorbidities: A systematic review

Cespiati,

Coelho Rodrigues,

Santos

et al. 2024

Liver International

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Background and AimsThe beneficial effect of Hepatitis C virus (HCV) eradication by direct antiviral agents (DAAs) on liver fibrosis is well defined. Despite this, the impact of viral eradication in both hepatic and extra‐hepatic metabolic features is underreached. This systematic review aimed to synthesize the evidence on the impact of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, glucidic impairment, dyslipidaemia, and weight gain.MethodsA systematic search of the existing literature (up to December 2022) identified 97 original studies that fulfilled the inclusion criteria.ResultsWhereas total cholesterol and low‐density lipoprotein (LDL) seem to increase after viral eradication, the cardiovascular damage expressed as carotid plaques and intima‐media thickness seems to improve. Otherwise, the effect on liver steatosis, glucidic homeostasis, and weight seems to be strictly dependent on the presence of baseline metabolic disorders.ConclusionDespite high heterogeneity and relatively short follow‐up of included studies, we can conclude that the presence of metabolic risk factors should be strictly evaluated due to their impact on liver steatosis, glucidic and lipid homeostasis, and on weight gain to better identify patients at risk of liver disease progression despite the virus eradication.

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Section: Resultsmentioning

confidence: 99%

Effect of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, and associated metabolic comorbidities: A systematic review

Cespiati,

Coelho Rodrigues,

Santos

et al. 2024

Liver International

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“…Further, >50% of people infected with chronic hepatitis C virus (CHC) generally develop long-term effects. Owing to the inflammation and infection mechanism, some previous studies have shown that patients with CHC infection have a trend relation with type 2 diabetes and magnified cardiovascular diseases compared with those without hepatitis C virus infection [ 25 , 26 , 27 ]. In addition, many patients with CHC infection also develop extrahepatic health problems, such as diabetes mellitus, heart disease, hypertension, stroke, and renal impairment [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Lately, DAAs such as asunaprevir/daclatasvir, elbasvir/grazoprevir, and ledipasvir/sofosbuvir have enhanced cure rates with >95% efficiency, few side effects, and a short treatment time of 2–3 months [ 24 , 28 , 29 ]. Furthermore, DAA treatment is beneficial for hepatitis C virus clearance and is associated with better cardiometabolic function, including mitigated fasting glucose and glycated hemoglobin levels [ 26 , 27 ]. Eradication of the hepatitis C virus infection in 2030 has been announced by the World Health Organization [ 23 ], and the Taiwan Department of Health has set a goal for hepatitis C elimination by 2025 with free DAA treatment [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Health Inequality among Fishery Workers during Climate Change: A National Population-Based and Retrospective Longitudinal Cohort Study

Lin

Huang

et al. 2022

IJERPH

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Background: Owing to specific working environments, it is important to attain sustainable development goals for the health of fishery workers during climate change. Fishery workers have a hazardous working environment, leading to specific injuries and fatal events. However, limited studies have investigated the health status of fishery workers through long-term longitudinal follow-up and compared it with that of farmers and employed workers with similar socioeconomic status. Methods: The Longitudinal Health Insurance Database 2000, a subset of the Taiwan National Health Insurance Research Database was used for this retrospective cohort study. Only fishery workers, farmers, and employed workers were included. Based on the majority of causes of death and related diseases, participants newly diagnosed with 18 diseases, classified into cardiometabolic diseases, mental illness, chronic kidney disease, infection, and malignancy, were included. Participants with an old diagnosis of these diseases were excluded. All included participants were followed up from 1 July 2000 to the diagnosis and withdrawal date, or 31 December 2012, whichever occurred first. Due to the substantial difference in the baseline demographics, we executed a cohort study with propensity score-matched and applied the Cox model to explore the participants’ health status. Results: After matching, there were negligible differences in the baseline demographics of fishery workers, farmers, and employed workers. Compared to farmers and employed workers, fishery workers were more frequently diagnosed with 11 and 14 diseases, respectively, such as hypertension (hazard ratio [HR]: 1.11, p < 0.01), diabetes (HR: 1.21, p < 0.001), dyslipidemia (HR: 1.18, p < 0.001), depression (HR: 1.38, p < 0.001), peptic ulcer (HR: 1.17, p < 0.001), chronic viral hepatitis (HR: 2.06, p < 0.001), hepatocellular carcinoma (HR: 1.67, p < 0.001), and total malignancy (HR: 1.26, p < 0.001). Conclusions: Compared to farmers and employed workers, fishery workers were more impacted by cardiometabolic diseases, mental illness, infection, and malignancy. Therefore, it is imperative to specifically focus on health policies for fishery workers, such as providing curable antiviral treatment and initiating culture-tailored health promotion programs, to mitigate health inequality.

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Nonalcoholic Fatty Liver Disease Within Other Causes of Chronic Liver Diseases

Gheorghe

Iacob

2023

Essentials of Non-Alcoholic Fatty Liver Disease

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The impact of HCV eradication on hyperglycemia, insulin resistance, cytokine production, and insulin receptor substrate-1 and 2 expression in patients with HCV infection

Cited by 5 publications

References 47 publications

Effect of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, and associated metabolic comorbidities: A systematic review

Effect of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, and associated metabolic comorbidities: A systematic review

Health Inequality among Fishery Workers during Climate Change: A National Population-Based and Retrospective Longitudinal Cohort Study

Nonalcoholic Fatty Liver Disease Within Other Causes of Chronic Liver Diseases

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