The impact of hearing loss on cognitive impairment: The mediating role of depressive symptoms and the moderating role of social relationships

Cao, Xia; Liu, Qian; Liu, Jiali; Yang, Bingfang; Zhou, Jiansong

doi:10.3389/fpubh.2023.1149769

Cited by 8 publications

(8 citation statements)

References 69 publications

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“…Our results also seem to contrast with a recent study, finding that “depressive symptoms partially mediated the association between hearing loss and cognitive function [standardized regression B coefficient (β) = −0.114; 95% confidence interval (CI): (−0.158, −0.076)] ( 128 ). Despite this apparent inconsistency, we believe that there is basically no contradiction between the two studies.…”

Section: Discussioncontrasting

confidence: 99%

Hearing loss, depression, and cognition in younger and older adult CI candidates

Huber,

Reuter,

Weitgasser

et al. 2023

Front. Neurol.

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Background and AimHearing loss in old age is associated with cognitive decline and with depression. Our study aimed to investigate the relationship between hearing loss, cognitive decline, and secondary depressive symptoms in a sample of younger and older cochlear implant candidates with profound to severe hearing loss.MethodsThis study is part of a larger cohort study designated to provide information on baseline data before CI. Sixty-one cochlear implant candidates with hearing loss from adulthood onwards (>18 years) were enrolled in this study. All had symmetrical sensorineural hearing loss in both ears (four-frequency hearing threshold difference of no more than 20 dB, PTA). Individuals with primary affective disorders, psychosis, below-average intelligence, poor German language skills, visual impairment, and a medical diagnosis with potential impact on cognition (e.g., neurodegenerative diseases,) were excluded. Four-frequency hearing thresholds (dB, PTA, better ear) were collected. Using the Abbreviated Profile of Hearing Aid Benefit, we assessed subjective hearing in noise. Clinical and subclinical depressive symptoms were assessed with the Beck Depression Inventory (BDI II). Cognitive status was assessed with a neurocognitive test battery.ResultsOur findings revealed a significant negative association between subjective hearing in noise (APHAB subscale “Background Noise”) and BDII. However, we did not observe any link between hearing thresholds, depression, and cognition. Additionally, no differences emerged between younger (25–54 years) and older subjects (55–75 years). Unexpectedly, further unplanned analyses unveiled correlations between subjective hearing in quiet environments (APHAB) and cognitive performance [phonemic fluency (Regensburg Word Fluency), cognitive flexibility (TMTB), and nonverbal episodic memory (Nonverbal Learning Test), as well as subjective hearing of aversive/loud sounds (APHAB)], cognitive performance [semantic word fluency (RWT), and inhibition (Go/Nogo) and depression]. Duration of hearing loss and speech recognition at quiet (Freiburg Monosyllables) were not related to depression and cognitive performance.ConclusionImpact of hearing loss on mood and cognition appears to be independent, suggesting a relationship with distinct aspects of hearing loss. These results underscore the importance of considering not only conventional audiometric measures like hearing thresholds but also variables related to hearing abilities during verbal communication in everyday life, both in quiet and noisy settings.

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Section: Discussioncontrasting

confidence: 99%

Hearing loss, depression, and cognition in younger and older adult CI candidates

Huber,

Reuter,

Weitgasser

et al. 2023

Front. Neurol.

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“…To examine the moderating effect of social support more comprehensively, this study extended it to social relations, including social activities, social networks, and social support. This concept has been applied in previous studies ( 45 , 72 ).…”

Section: Discussionmentioning

confidence: 99%

Association between disability and cognitive function in older Chinese people: a moderated mediation of social relationships and depressive symptoms

Ai,

Li,

Dong

et al. 2024

Front. Public Health

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ObjectiveMany previous studies have found that disability leads to cognitive impairment, and in order to better understand the underlying mechanisms between disability and cognitive impairment, the present study aimed to investigate the moderating role of social relationships, including their role as mediators between disability and cognitive impairment in depressive symptoms.Study designThis is a cross-sectional study.MethodsA total of 5,699 Chinese older adults from the 2018 China Longitudinal Healthy Longevity Survey (CLHLS) were included in this study, and PROCESS macro was used to perform simple mediator and moderator mediator analyses, which were used to analyze the relationship between depressive symptoms and social relationships between disability and cognitive impairment.ResultsThe results of this study showed significant correlations between disability, cognitive impairment, depressive symptoms, and social relationships, and that depressive symptoms mediated the relationship between disability and cognitive functioning [B = −0.232; 95% CI: (−0.304, −0.164)], and that social relationships mediated disability and cognitive functioning through pathway a (Disability-Depressive Symptoms) [B = 0.190; 95% CI: (0.020, 0.036)], path b (depressive symptoms-cognitive impairment) [B = 0.029; 95% CI: (0.015, 0.042)], and path c’ (incapacitation-cognitive impairment) [B = 0.492; 95% CI: (0.298, 0.685)] to modulate the effect of incapacitation on cognitive impairment. In addition, social activities and social networks moderated the mediation model directly or indirectly, whereas social support moderated only the direct effect.ConclusionThis study explains the intrinsic link between incapacitation and cognitive impairment in Chinese older adults, and that social relationships and depressive symptoms can directly or indirectly modulate the effects between them. This provides a basis for healthcare professionals to be able to better develop interventions that can be used to improve the level of cognitive functioning and mental health of older adults.

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“…This financial burden is accompanied by increased risks of conditions like Alzheimer’s disease and dementia in individuals with age-related hearing loss [ 2 , 3 ]. Additionally, individuals with hearing loss often face communication difficulties that lead to linguistic degradation, reduced social engagement, social isolation, emotional detachment, and depression [ 4 , 5 ]. Among the factors contributing to hearing loss, ototoxic mechanisms have been a central focus, with clinical research primarily centered around the adverse effects of platinum-based drugs and aminoglycosides [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Association between blood volatile organic aromatic compound concentrations and hearing loss in US adults

Wang,

Luo,

Zhang

et al. 2024

BMC Public Health

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Objective Benzene, ethylbenzene, meta/para-xylene, and ortho-xylene, collectively referred to as benzene, ethylbenzene, and xylene (BEX), constitute the main components of volatile organic aromatic compounds (VOACs) and can have adverse effects on human health. The relationship between exposure to BEX and hearing loss (HL) in the adult U.S. population was aimed to be assessed. Methods Cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) for the years 2003–2004, 2011–2012, and 2015–2016 were analyzed. This dataset included complete demographic characteristics, pure-tone audiometry measurements, and volatile organic compound detection data from the NHANES database. A weighted multivariate logistic regression model was employed to investigate the associations between blood BEX concentrations HL, low-frequency hearing loss (SFHL), and high-frequency hearing loss (HFHL). Results 2174 participants were included, with weighted prevalence rates of HL, SFHL, and HFHL being 46.81%, 25.23%, and 45.86%, respectively. Exposure to benzene, ethylbenzene, meta/para-xylene, and ortho-xylene, and cumulative BEX concentrations increased the risk of hearing loss (odds ratios [ORs] were 1.36, 1.22, 1.42, 1.23, and 1.31, respectively; all P < 0.05). In the analysis with SFHL as the outcome, ethylbenzene, m-/p-xylene, o-xylene, benzene, and overall BEX increased the risk (OR 1.26, 1.21, 1.28, 1.20, and 1.25, respectively; all P < 0.05). For HFHL, exposure to ethylbenzene, m-/p-xylene, o-xylene, benzene, and overall BEX increased the risk (OR 1.36, 1.22, 1.42, 1.22, and 1.31, respectively; all P < 0.05). Conclusion Our study indicated that a positive correlation between individual or cumulative exposure to benzene, ethylbenzene, meta/para-xylene, and ortho-xylene and the risk of HL, SFHL, and HFHL. Further research is imperative to acquire a more comprehensive understanding of the mechanisms by which organic compounds, notably BEX, in causing hearing loss and to validate these findings in longitudinal environmental studies.

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The impact of hearing loss on cognitive impairment: The mediating role of depressive symptoms and the moderating role of social relationships

Cited by 8 publications

References 69 publications

Hearing loss, depression, and cognition in younger and older adult CI candidates

Hearing loss, depression, and cognition in younger and older adult CI candidates

Association between disability and cognitive function in older Chinese people: a moderated mediation of social relationships and depressive symptoms

Association between blood volatile organic aromatic compound concentrations and hearing loss in US adults

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