The Impact of Hemp Seed Oil on Drug-Drug Interactions: A Comprehensive Review of Potential Mechanisms and Clinical Implications

Abstract

Hemp seed oil (HSO), esteemed for its potential health benefits and therapeutic attributes, has garnered substantial attention in recent years. However, the escalating consumption of HSO has engendered apprehensions regarding its potential interactions with pharmaceutical medications, posing the risk of adverse effects or altered drug efficacy. This comprehensive review diligently explores and elucidates the underlying mechanisms through which HSO may interact with a spectrum of drugs, accompanied by an extensive assessment of the clinical ramifications of these interactions. By assiduously unraveling these intricate dynamics, this review equips healthcare professionals and consumers with the knowledge to make judicious decisions concerning the concurrent use of HSO and prescription medications. Moreover, this comprehensive review endeavors to identify and address research gaps, charting a route for future investigations in this critical domain. This review sheds light on HSO's impact on drug-drug interactions (DDIs), delivering invaluable insights for healthcare professionals, researchers, and consumers and fostering the responsible and informed incorporation of this natural product across diverse therapeutic contexts.

Cannabis sativa: 2023-Outbreak and Re-emergence of Nipah virus (NiV) in India: Role of Hemp oil

“…Another major problem is increasing trend of combining hemp seed oil with pharmaceutical medications has raised concerns among healthcare professionals and researchers about the possibility of drug-drug interactions [22]. Drug interactions occur when the effects of one medication are altered by the presence of another substance, potentially leading to adverse effects, diminished drug efficacy, delivery, metabolism, or other unexpected outcomes [22]. Given that hemp seed oil and pharmaceutical drugs can be metabolized and interact with common cellular pathways and enzymes, the potential for drug-drug interactions demands careful investigation [21,22].…”

“…Drug interactions occur when the effects of one medication are altered by the presence of another substance, potentially leading to adverse effects, diminished drug efficacy, delivery, metabolism, or other unexpected outcomes [22]. Given that hemp seed oil and pharmaceutical drugs can be metabolized and interact with common cellular pathways and enzymes, the potential for drug-drug interactions demands careful investigation [21,22].…”

“…During, Covid-19, the infusion of Cannabis flower with a morning cup of tea has saved the life of many people . Cannabis oil was used as dengue mosquito repellent for controlling dengue viral fever [26][27][28][29][30][31][32][33][34][35][36][37], bacterial infections and fungal diseases [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37].…”