The impact of hepatitis C viremia status on lung functions in chronic hepatitis c patients

Bal, Tayibe; Önlen, Yüsüf; Babayiğit, Cenk; Yümer, Yusuf; Şahin, Selma İlkay

doi:10.4314/ahs.v19i2.21

Cited by 6 publications

(6 citation statements)

References 14 publications

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“…Results were in line with the previous study. [15] Similarly, the study by Mahmoud M. El-Habashy et al found that patients with COPD who also had chronic HCV infection had significantly lower lung function than those who did not have HCV. These results imply that persistent HCV infection contributes to the rapid decrease of pulmonary function seen in COPD patients.…”

Section: Discussionmentioning

confidence: 94%

Assess Restricted Pulmonary Function in Chronic Hepatitis C Patients at Various Phases

Rahman¹,

Rizwan²,

Hameed³

et al. 2022

PJMHS

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Background: Chronic hepatitis C infection has both hepatic and extra-hepatic symptoms, both of which are influenced by the inflammatory response triggered by HCV. Chronic HCV induces inflammation that manifests itself in the liver and beyond. Persistent HCV infection may be associated with reduced pulmonary functions especially in patients with high viremia levels. Objective: The objective of study was to examine restricted pulmonary function in chronic hepatitis C patients during different phases. Study Design: Cross-sectional study Place and Duration: Department of Medicine Social Security Teaching Hospital Ferozepure Road Lahore. From 01.02.2022 to 30.08.2022. Methods: There were 94 cases of chronic hepatitis included in this study. After gaining the participants' informed consent, we documented their age, sex, BMI, and smoking status in detail. Patients underwent for abdominal ultrasound. The anti-HCV antibody test was run with a third-generation ELISA (Ortho HCV ELISA) kit using 3 ml of blood and pulmonary function test were performed to eavaluate restrictive lung disease. Data was entered and analyzed in SPSS 24.0 and presented as frequency and percentages. Results: Among 94 cases, 57 (60.6%) were males and 37 (39.4%) were females. Mean age of the patients was 46.9±4.53 years and mean BMI was 25.4±6.29 kg/m2. Majority of the cases 51 (54.3%) had rural residency. There were 64 (68.1%) cases had smoking history. We found that 17 (18.1%) cases had severe HCV, 45 (47.9%) cases had moderate and 32 (34.04%) patients had mild HCV. There were 37 (39.4%) cases had restrictive pulmonary function among all cases. Among 37 cases of pulmonary disease, majority had severe HCV infection. Conclusion: We concluded in this study that the patient with HCV infection had higher incidence of restrictive pulmonary disease. Majority of the patients were males and had smoking history. Severe cases of HCV mostly had restrictive disease. Keywords: HCV, Restrictive Pulmonary Disease, Males, Smoking

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Section: Discussionmentioning

confidence: 94%

Assess Restricted Pulmonary Function in Chronic Hepatitis C Patients at Various Phases

Rahman¹,

Rizwan²,

Hameed³

et al. 2022

PJMHS

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“…The other finding here was the association between chronic hepatitis C infection and fetal pulmonary neuroendocrine cells, which has not been reported in any study so far. Bal et al, reported that patients having high doses of serum chronic hepatitis C RNA levels were 14.2 times more likely to show pulmonary dysfunction than non-viremic patients [ 57 ]. Segna and Dufour also reviewed the association between the hepatitis C virus (HCV) and endocrine and pulmonary manifestations [ 58 ].…”

Section: Resultsmentioning

confidence: 99%

Single-Cell Chromatin Accessibility Data Combined with GWAS Improves Detection of Relevant Cell Types in 59 Complex Phenotypes

Das

Qian

Naghavi

et al. 2022

IJMS

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Several disease risk variants reside on non-coding regions of DNA, particularly in open chromatin regions of specific cell types. Identifying the cell types relevant to complex traits through the integration of chromatin accessibility data and genome-wide association studies (GWAS) data can help to elucidate the mechanisms of these traits. In this study, we created a collection of associations between the combinations of chromatin accessibility data (bulk and single-cell) with an array of 201 complex phenotypes. We integrated the GWAS data of these 201 phenotypes with bulk chromatin accessibility data from 137 cell types measured by DNase-I hypersensitive sequencing and found significant results (FDR adjusted p-value ≤ 0.05) for at least one cell type in 21 complex phenotypes, such as atopic dermatitis, Graves’ disease, and body mass index. With the integration of single-cell chromatin accessibility data measured by an assay for transposase-accessible chromatin with high-throughput sequencing (scATAC-seq), taken from 111 adult and 111 fetal cell types, the resolution of association was magnified, enabling the identification of further cell types. This resulted in the identification of significant correlations (FDR adjusted p-value ≤ 0.05) between 15 categories of single-cell subtypes and 59 phenotypes ranging from autoimmune diseases like Graves’ disease to cardiovascular traits like diastolic/systolic blood pressure.

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“…These sometimes affects lung function, which leads to secondary effects with symptoms of progressive liver disease and drug treatment for HCV. Also, the presence of viremia is associated with a spirometric abnormality due to inflammation of the lungs (23). China is reported to have a varying prevalence of HCV infection compared to the neighboring countries (4,24).…”

Section: Discussionmentioning

confidence: 99%

“…sure of oxygen with that of carbon dioxide. According to the findings, patients with a positive HCV RNA had raised liver function tests compared to those with a negative anti-HCV antibody test (23). Subclinical HCV infection increases the risk of deterioration of liver functions.…”

Section: (36)mentioning

confidence: 98%

Subclinical Hepatitis C Virus Infection in Patients with Chronic Obstructive Pulmonary Disease: Evidence from a Cross-Sectional Multicenter Observation Study

Bai

Tian

2021

Jundishapur J Microbiol

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Background: Patients with hepatitis virus C (HCV) infection have declined levels of forced expiratory volume (FEV), which is a prognostic marker for chronic obstructive pulmonary disease (COPD). Objectives: The current study primarily aimed to investigate the incidence of subclinical HCV infection (clinical signs are absent but positive HCV RNA test performed by polymerase chain reaction) in patients with COPD of Zhejiang province, China, and its secondary aim was to investigate the clinical influence of HCV infection on COPD severity by body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) scoring index and pulmonary function tests (PFT). Methods: A total of 252 patients with COPD (confirmed by routine lab tests, BODE index, and PFT) were included in a cross-sectional multicenter study. An anti-HCV antibody test was used to diagnose HCV infection. Hepatitis virus C RNA was tested for patients with a HCV antibody-positive test. Results: Twelve patients had a positive anti-HCV antibody test. Of 12 anti-HCV antibody positive test patients, 10 were positive for the HCV RNA. The prevalence of anti-HCV antibody positivity and HCV RNA positivity was 12/ 252 and 10/ 252, respectively. The partial arterial pressure of oxygen was the same for patients with HCV RNA positive test compared to those with a negative anti-HCV antibody test (59.70 ± 5.50 mmHg vs. 63.84 ± 15.63 mmHg, P = 0.791). Patients with a positive HCV RNA test had a higher partial arterial pressure of carbon dioxide compared to those with a negative anti-HCV antibody test (43.70 ± 1.89 mmHg vs. 49.42 ± 7.33 mmHg, P = 0. 007). BODE index was higher for patients with HCV RNA positive test than those with anti-HCV antibody test negative (6 (3 - 7) vs. 4 (2 - 6), P < 0.0001). Among the variables of BODE index scoring, the values of distance walked in 6 min (P < 0.0001) and % predicted forced expiratory volume in 1 s (P < 0.0001) were fewer for patients with HCV RNA positive test than those with a negative anti-HCV antibody test. Conclusion: This study demonstrated that subclinical HCV infection may be observed in COPD patients.

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The impact of hepatitis C viremia status on lung functions in chronic hepatitis c patients

Cited by 6 publications

References 14 publications

Assess Restricted Pulmonary Function in Chronic Hepatitis C Patients at Various Phases

Assess Restricted Pulmonary Function in Chronic Hepatitis C Patients at Various Phases

Single-Cell Chromatin Accessibility Data Combined with GWAS Improves Detection of Relevant Cell Types in 59 Complex Phenotypes

Subclinical Hepatitis C Virus Infection in Patients with Chronic Obstructive Pulmonary Disease: Evidence from a Cross-Sectional Multicenter Observation Study

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