The Impact of Herbal Products in the Prevention, Regeneration and Delay of Skin Aging

Abstract

Advances in Experimental Medicine and Biology presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research. Advances in Experimental Medicine and Biology has been publishing exceptional works in the field for over 30 years and is indexed in Medline, Scopus, EMBASE, BIOSIS, Biological Abstracts, CSA, Biological Sciences and Living Resources (ASFA-1), and Biological Sciences. The series also provides scientists with up-to-date information on emerging topics and techniques. 2018 Impact Factor: 2.126 Content of this series is reviewed.

Citrulluside H and citrulluside T from young watermelon fruit attenuate ultraviolet B radiation‐induced matrix metalloproteinase expression through the scavenging of generated reactive oxygen species in human dermal fibroblasts

“…15,16 Currently, combination therapy is an attractive strategy involving the impaired intrinsic antioxidant defense system complemented by exogenous factors, such as polyphenols and vitamins present in natural products. [5][6][7][8][17][18][19] In the present study, two novel phenolic glycosides, namely citrulluside UV-B changes the structure of trans-urocanic acid and tryptophan to cis-urocanic acid and 6-formylindolo-3,2-carbazole (FICZ), respectively, which alters their original biological activities. 27 FICZ is well established as an endogenous aryl hydrocarbon receptor (AhR) ligand.…”

“…As a defense mechanism against photoaging‐induced skin disorders, the skin is endogenously equipped with antioxidants and antioxidant enzymes; however, owing to aging and the resultant skin damage, these defenses are unable to process the ROS generated by UV irradiation 15,16 . Currently, combination therapy is an attractive strategy involving the impaired intrinsic antioxidant defense system complemented by exogenous factors, such as polyphenols and vitamins present in natural products 5‐8,17‐19 . In the present study, two novel phenolic glycosides, namely citrulluside H and citrulluside T, obtained from young watermelon fruit, were found to suppress UV‐B – induced MMP expression in NHDFs via downregulation of the MAPK/AP‐1 and NF‐κB signaling pathways activated by ROS (Figure 6).…”

“…We recently isolated two novel phenolic glycosides that exhibit antioxidant properties: citrulluside H (2‐caffeoyl‐3‐hydroxy‐3‐methylbutyric 4’‐β‐D‐glucopyranosyloxy‐3’‐hydroxybenzyl ester) and citrulluside H (2‐caffeoyl‐3‐hydroxy‐3‐methylbutyric 4’‐β‐D‐glucopyranosyloxybenzyl ester) from young watermelon ( Citrullus lanatus ) fruit, which is prematurely harvested following cultivation 4 . Several studies have indicated that such phytochemicals with antioxidant properties suppress the UV‐R–induced degradation of the dermal extracellular matrix (DECM) by inhibiting intracellular ROS generation 5‐8 . Therefore, in the present study, we examined whether these two novel compounds attenuate UV‐B–induced photoaging in normal human dermal fibroblasts (NHDFs), as well as their underlying mechanisms.…”

“…4 Several studies have indicated that such phytochemicals with antioxidant properties suppress the UV-R-induced degradation of the dermal extracellular matrix (DECM) by inhibiting intracellular ROS generation. [5][6][7][8] Therefore, in the present study, we examined whether these two novel compounds attenuate UV-B-induced photoaging in normal human dermal fibroblasts (NHDFs), as well as their underlying mechanisms.…”

Assessment of Topical and Transdermal Penetration of Curcuma heyneana Rhizome Extract in Rat Skin: Histological Analysis

“…In previous research, we have shown that the ethanol extract of Curcuma heyneana rhizome has an antioxidant and antiaging activity that protects the skin from the damaging effects of excessive UV exposure [7][8][9]. This study used a histomorphometric method of rats exposed to UV light [10].…”