The impact of hip fracture on health-related quality of life and activities of daily living: the SPARE-HIP prospective cohort study

Prieto‐Alhambra, Daniel; Moral-Cuesta, Débora; Palmer, Antony; Aguado-Maestro, I.; Bardaji, Manuel Francisco Bravo; Brañas, Fátima; Bueno, G Adrados; Caeiro-Rey, José Ramón; Cano, Ignacio Andrés; Barrés-Carsí, Mariano; Delgado, Luis Gracia; Salomó-Domènech, M.; Etxebarría-Foronda, I.; Ferrer, Bartolomé Lladó; Mills, Sarah; Ezquerra, Laura; Mifsut, Damián; Evangelista, Luana; Nogués, Xavier; Pérez-Coto, Iván; Blasco, Jorge Martínez-Iñiguez; Martín-Hernández, C.; Kessel, H.; Teixidor-Serra, Jordi; Solís, Juan Rodríguez; Suau, Óscar Torregrosa; Vaquero-Cervino, E.; Hernández, C. Pablos; Mañas, Leocadio Rodríguez; Herrera, Antonio; Díez-Pérez, Adolfo

doi:10.1007/s11657-019-0607-0

Cited by 21 publications

(16 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In any case, these recent papers criticized the usefulness of vitamin D supplementation with the goal to maintain or improve musculoskeletal health in the general population, but its role in patients receiving treatment for osteoporosis is an entirely different topic. It is well-known that, in these patients, adequate calcium and vitamin D intake are essential, and their deficiency represents the most common reason for lack of response to any treatment, 5,8,9 This observation has been confirmed also in a recent large retrospective study based on Italian administrative databases. 4 The study showed once again that pharmacological treatments for osteoporosis are associated with a lower risk for both refracture and all-cause mortality to a greater extent when they are administered in combination with calcium and vitamin D. 4…”

Section: Requirements For Therapymentioning

confidence: 71%

“…4 Their recovery is usually slow and often incomplete. 5 For these reasons, a large proportion of fractured individuals is destined to lose function and independence and to suffer from persistent pain and decreased quality of life. 5 Due to the progressive aging of the general population, the annual incidence of fragility fractures is expected to rise from 3.5 million in 2010 to 4.5 million in 2025.…”

mentioning

confidence: 99%

“…5 For these reasons, a large proportion of fractured individuals is destined to lose function and independence and to suffer from persistent pain and decreased quality of life. 5 Due to the progressive aging of the general population, the annual incidence of fragility fractures is expected to rise from 3.5 million in 2010 to 4.5 million in 2025. 2 In the last three decades, pharmacological treatments of osteoporosis have shown to be effective and able to reduce the fracture risk by about 50%, with consequent benefits on the patients' health status.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Pharmacological Management of Osteoporosis in Postmenopausal Women: The Current State of the Art

Gatti

Fassio

2019

jptcp

View full text Add to dashboard Cite

Osteoporosis is a common disease that increases fracture risk. Fragility fractures bring heavy consequences in terms of mortality and disability, with burdensome health and social costs. In subjects with clinical bone fragility, the first goal is to identify the secondary forms of osteoporosis, especially in young subjects, in males and in patients who recently experienced a fragility fracture. In addition, before considering any sort of treatment, it is fundamental to check for adequate calcium and vitamin D intake, since their deficiency is the most common reason for drug failure. In the last decade of the 20th century, several molecules have been developed and proved to be effective in achieving the true goal of any antiosteoporotic drug: fracture prevention. In this article, we considered the most commonly prescribed antiresorptive drugs (hormonal therapy, bisphosphonates, and denosumab), the anabolic agents (teriparatide), the dual-action drugs (romosozumab), and the drugs characterized by an unclear mechanism of action (strontium ranelate) to provide physicians with useful insights for their clinical practice. We discussed the main criteria for the appropriate choice selection and management of each treatment. Finally, we addressed the current controversies related to treatment discontinuation, sequential, and combination therapy.

show abstract

Section: Requirements For Therapymentioning

confidence: 71%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Pharmacological Management of Osteoporosis in Postmenopausal Women: The Current State of the Art

Gatti

Fassio

2019

jptcp

View full text Add to dashboard Cite

show abstract

“…Intertrochanteric fracture is a common osteoporotic fracture among elderly populations in an aging society [1][2][3]. Multiple comorbidities result in high rates of morbidity and mortality, which makes intertrochanteric fractures challenging to treat for orthopedic surgeons [4][5][6]. Early surgical xation on these aging patients has been proposed recently for early rehabilitation and has had a positive impact on reducing comorbidities [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…The lag screw tip position in the femoral head was classi ed by the Cleveland index (Figure 2a) [22]. 5. Femoral neck shortening: The femoral neck shortening distance was measured between the last follow-up and the immediate postoperative radiographs with the correction of the true implant diameters.…”

mentioning

confidence: 99%

Similarities between Inferior-Center and Center-Center Lag Screw Positions in Femoral Intertrochanteric Fracture Surgeries

Yeh

Liu

Chou

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The center-center lag screw position has been widely accepted as the optimal lag screw/helical blade position in femoral intertrochanteric fracture surgery to achieve a tip-apex distance (TAD) less than 25 mm. Despite the inferior-center lag screw/helical blade position having some biomechanical advantages, and the emergence of calcar-referenced tip-apex distance (CalTAD), the clinical differences between the two commonly placed lag screw/helical blade positions remain unclear. This study aimed to (1) report radiological outcomes in managing geriatric femoral intertrochanteric fractures, (2) identify the influences of positions of lag screw/helical blade, and (3) identify the relationship between implants and the values of TAD and CalTAD.Methods: We retrospectively assessed the clinical and radiographic findings of geriatric patients (age ≥ 55 years) who underwent surgery for acute closed femoral intertrochanteric fractures during 1-year period and were followed up a minimum of 6 months. The radiographic parameters and incidences of fixation failure were compared between the different lag screw and helical blade positions (center-center vs. inferior-center). Subgroup analyses of different implant types (extramedullary and intramedullary) were also performed for comparisons for different lag screw positions, and TAD and CalTAD beyond the normal standard value of 25 mm.Results: A total of 206 patients were included during the study period, with a 7.8% fixation failure. There were no differences in incidences of fixation failure between the commonly inserted lag screw/helical blade positions (center-center vs. inferior-center), regardless of the implant types. Those with a TAD > 25 mm had significantly higher incidence of fixation failure than those with a TAD ≤ 25 mm in the extramedullary plate (17.0% vs. 1.2%, p = 0.001), but not in the intramedullary nails (16.1% vs. 4.4%, p = 0.08). There were no significant differences in incidences of fixation failure between CalTAD ≤ 25 mm and CalTAD > 25 mm in either extramedullary or intramedullary implants. Conclusion: Although TAD > 25 mm might increase the fixation failure rate in extramedullary plates, an inferior-center lag screw/helical blade position could achieve comparable radiographic results as a center-center position after osteosynthesis for geriatric femoral intertrochanteric fractures.

show abstract

Artificial Intelligence for Hip Fracture Detection and Outcome Prediction

et al. 2023

View full text Add to dashboard Cite

ImportanceArtificial intelligence (AI) enables powerful models for establishment of clinical diagnostic and prognostic tools for hip fractures; however the performance and potential impact of these newly developed algorithms are currently unknown.ObjectiveTo evaluate the performance of AI algorithms designed to diagnose hip fractures on radiographs and predict postoperative clinical outcomes following hip fracture surgery relative to current practices.Data SourcesA systematic review of the literature was performed using the MEDLINE, Embase, and Cochrane Library databases for all articles published from database inception to January 23, 2023. A manual reference search of included articles was also undertaken to identify any additional relevant articles.Study SelectionStudies developing machine learning (ML) models for the diagnosis of hip fractures from hip or pelvic radiographs or to predict any postoperative patient outcome following hip fracture surgery were included.Data Extraction and SynthesisThis study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses and was registered with PROSPERO. Eligible full-text articles were evaluated and relevant data extracted independently using a template data extraction form. For studies that predicted postoperative outcomes, the performance of traditional predictive statistical models, either multivariable logistic or linear regression, was recorded and compared with the performance of the best ML model on the same out-of-sample data set.Main Outcomes and MeasuresDiagnostic accuracy of AI models was compared with the diagnostic accuracy of expert clinicians using odds ratios (ORs) with 95% CIs. Areas under the curve for postoperative outcome prediction between traditional statistical models (multivariable linear or logistic regression) and ML models were compared.ResultsOf 39 studies that met all criteria and were included in this analysis, 18 (46.2%) used AI models to diagnose hip fractures on plain radiographs and 21 (53.8%) used AI models to predict patient outcomes following hip fracture surgery. A total of 39 598 plain radiographs and 714 939 hip fractures were used for training, validating, and testing ML models specific to diagnosis and postoperative outcome prediction, respectively. Mortality and length of hospital stay were the most predicted outcomes. On pooled data analysis, compared with clinicians, the OR for diagnostic error of ML models was 0.79 (95% CI, 0.48-1.31; P = .36; I2 = 60%) for hip fracture radiographs. For the ML models, the mean (SD) sensitivity was 89.3% (8.5%), specificity was 87.5% (9.9%), and F1 score was 0.90 (0.06). The mean area under the curve for mortality prediction was 0.84 with ML models compared with 0.79 for alternative controls (P = .09).Conclusions and RelevanceThe findings of this systematic review and meta-analysis suggest that the potential applications of AI to aid with diagnosis from hip radiographs are promising. The performance of AI in diagnosing hip fractures was comparable with that of expert radiologists and surgeons. However, current implementations of AI for outcome prediction do not seem to provide substantial benefit over traditional multivariable predictive statistics.

show abstract

The impact of hip fracture on health-related quality of life and activities of daily living: the SPARE-HIP prospective cohort study

Cited by 21 publications

References 16 publications

Pharmacological Management of Osteoporosis in Postmenopausal Women: The Current State of the Art

Pharmacological Management of Osteoporosis in Postmenopausal Women: The Current State of the Art

Similarities between Inferior-Center and Center-Center Lag Screw Positions in Femoral Intertrochanteric Fracture Surgeries

Artificial Intelligence for Hip Fracture Detection and Outcome Prediction

Contact Info

Product

Resources

About