The Impact of HLA Mismatches on the Survival of First Cadaveric Kidney Transplants

Abstract

Under ideal circumstances, a policy of maximal matching of cadaveric renal transplants would increase five-year graft survival by a comparatively small 4.4 percentage points, but the actual benefit is likely to be smaller.

MDRD-Estimated GFR at One Year Post-Renal Transplant Is a Predictor of Long-Term Graft Function

“…[9][10][11][12][13][14] These variables are useful prognostic indicators but are not helpful in the evaluation of maintenance immunosuppression regimes. Previous studies have demonstrated serum creatinine measured at one year to be a predictor of long-term graft survival.…”

HLA-A, -B, -C, -DR, and -DQ Matching in Pancreas Transplantation: Effect on Graft Rejection and Survival

“…For kidney recipients, studies agree on a general trend toward improved graft survival with decreasing numbers of combined HLA-A, -B, and -DR MMs (2,4,6,27). The major impact of matching is due to the HLA-DR and -B loci, with the HLA-A locus much less significant (3,28).…”

Current Concepts in Histocompatibility During Heart Transplant

“…14,15 controversial issues in human leukocyte antigen matching in a heart transplant The importance of HLA matching to improve outcome in kidney and bone marrow transplant has been widely accepted, whereas it is still debated in heart transplants. [16][17][18] There is a paucity of research on the clinical relevance of HLA matching in heart transplanting, because the HLA is not a selection criterion of the recipient's choice. Furthermore, heart disease patients have a severe short-term prognosis, and they cannot wait for a heart transplant with a high degree of HLA histocompatibility.…”