“…23 Those results have not been added to the tables, but they are consistent with the other reviews and analyses, that is, less blood loss and transfusion with tetrastarches compared with older starches; lack of adverse safety signals for blood loss, transfusion, and length of stay versus comparators; and lesser replacement volume than with crystalloids. In addition during this period, Kancir et al 24 reported the results of a randomized blinded trial in 38 patients undergoing elective hip arthroplasty, finding no adverse renal effects of HES 130/0.4 compared with saline, as evidenced by urinary NGAL, serum creatinine, or creatinine clearance.…”