The impact of hyperoxia on brain activity: A resting-state and task-evoked electroencephalography (EEG) study

Sheng, Min; Liu, Peiying; Mao, Deng; Ge, Yulin; Lu, Hanzhang

doi:10.1371/journal.pone.0176610

Cited by 20 publications

(17 citation statements)

References 41 publications

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“…In all these studies, however, behavioural state was not controlled and the influence of HYPEROXIA ON BRAIN ACTIVITY 5 physiological variables such as respiratory and heart rate changes were not taken into account. A recent study, however, reported decreases in EEG alpha activity during sustained-attention and task-evoked conditions, comparing 5-minute interleaved oxygen and control blocks (Sheng et al, 2017). While this study did control behavioural state under alert, sustained attention conditions, there has still been no systematic evaluation of the impact of hyperoxia on EEG oscillations in resting-state conditions.…”

Section: Introductionmentioning

confidence: 84%

Electrophysiological correlates of hyperoxia during resting-state EEG in awake human subjects

Vuong

Kizuk

MacLean

et al. 2018

Preprint

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Recreational use of concentrated oxygen has increased. Claims have been made that hyperoxic breathing can help reduce fatigue, increase alertness, and improve attentional capacities; however, few systematic studies of these potential benefits exist. Here we examined the effects of short-term (15 minute) hyperoxia on resting-states in awake human subjects by measuring spontaneous EEG activity between normoxic and hyperoxic situations, using a within-subjects design for both eyes-opened and eyes-closed conditions. We also measured respiration rate, heart rate, and blood oxygen saturation levels to correlate basic physiological changes due to the hyperoxic challenge with any brain activity changes. Our results show that breathing short term 100% oxygen led to increased blood-oxygen saturation levels, decreased heart rate, and a slight, but non-significant, decrease in breathing rate. Changes of brain activity were apparent, including decreases in low-alpha (7-10 Hz), high-alpha (10-14 Hz), beta (14-30 Hz), and gamma (30-50 Hz) frequency ranges during eyes-opened hyperoxic conditions. During eyes-closed hyperoxia, increases in the delta (0.5-3.5 Hz) and theta (3.5-7 Hz) frequency range were apparent together with decreases in the beta range. Hyperoxia appeared to accentuate the decrease of low alpha and gamma ranges across the eyes-opened and closed conditions suggesting that it modulated brain state itself. As decreased alpha during eyes-opened conditions has been associated with increased attentional processing and selective attention, and increased delta and theta during eyes-closed condition are typically associated with the initiation of sleep, our results suggest a state-specific and perhaps opposing influence of short-term hyperoxia.

show abstract

Section: Introductionmentioning

confidence: 84%

Electrophysiological correlates of hyperoxia during resting-state EEG in awake human subjects

Vuong

Kizuk

MacLean

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…Anesthesia was delivered for 6 min in air, then for 6 min in 80% oxygen, and finally in air again for 6 min. Anesthetic delivery was tested in air as well as in combination with 80% O 2 because anesthesia is often delivered in higher-than-air oxygen concentration and it has been shown that hyperoxia can affect neuronal activity in the awake state (Sheng et al 2017). Anesthesia was then stopped and recordings continued during the period of recovery for 20 minutes.…”

Section: Experimental Designmentioning

confidence: 99%

The effect of sevoflurane and isoflurane anesthesia on single unit and local field potentials

Aksenov¹,

Miller²,

Dixon³

et al. 2019

Exp Brain Res

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Volatile general anesthetics are used commonly in adults and children, yet their mechanisms of action are complex and the changes in single unit firing and synaptic activity that underlie the broad decreases in neuronal activity induced by these drugs have not been well characterized. Capturing such changes throughout the anesthesia process is important for comparing the effects of different anesthetics and gaining a better understanding of their mechanisms of action and their impact on different brain regions. Using chronically implanted electrodes in the rabbit somatosensory cortex, we compared the effects of two common general anesthetics, isoflurane and sevoflurane, on cortical neurons. Single unit activity and local field potentials (LFP) were recorded continuously before and during anesthetic delivery at 1 MAC, as well as during recovery. Our findings show that, although isoflurane and sevoflurane belong to the same class of volatile general anesthetics, their effects upon cortical single units and LFP were quite different. Overall, the suppression of neuronal firing was greater and more uniform under sevoflurane. Moreover, the changes in LFP frequency bands suggest that effect of anesthesia upon beta oscillations does not necessarily depend on the level of single unit activity, but rather on the changes in GABA/ glutamate neurotransmission induced by each drug.

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“…While different oscillatory states are associated with specific cognitive functions, our task did not specifically test a cognitive function, rather it simply demonstrated that there are oscillatory changes that occur under short‐term hyperoxia in resting‐state conditions. Sheng et al () recently demonstrated that hyperoxia was associated with reductions in alpha and beta power during both a sustained attention task and a visual ERP task. Our results similarly showed that hyperoxia was associated with decreases in alpha and beta power as well as proportion of detections during a resting‐state task when the eyes were opened but extended this to the comparison of eyes‐closed condition in which this decrease was lessened.…”

Section: Discussionmentioning

confidence: 99%

“…In all these studies, however, behavioral state was not controlled, and the influence of physiological variables such as respiratory and heart rate changes were not taken into account. A recent study, however, reported decreases in EEG alpha activity during sustained‐attention and task‐evoked conditions, comparing 5‐min interleaved oxygen and control blocks (Sheng, Liu, Mao, Ge, & Lu, ). While this study did control behavioral state under alert, sustained attention conditions, there has still been no systematic evaluation of the impact of hyperoxia on EEG oscillations in resting‐state conditions.…”

Section: Introductionmentioning

confidence: 96%

Electrophysiological correlates of hyperoxia during resting‐state EEG in awake human subjects

et al. 2019

View full text Add to dashboard Cite

Recreational use of concentrated oxygen has increased. Claims have been made that hyperoxic breathing can help reduce fatigue, increase alertness, and improve attentional capacities; however, few systematic studies of these potential benefits exist. Here, we examined the effects of short‐term (15 min) hyperoxia on resting states in awake human subjects by measuring spontaneous EEG activity between normoxic and hyperoxic situations, using a within‐subject design for both eyes‐opened and eyes‐closed conditions. We also measured respiration rate, heart rate, and blood oxygen saturation levels to correlate basic physiological changes due to the hyperoxic challenge with any brain activity changes. Our results show that breathing short‐term 100% oxygen led to increased blood oxygen saturation levels, decreased heart rate, and a slight, but nonsignificant, decrease in breathing rate. Changes of brain activity were apparent, including decreases in low‐alpha (7–10 Hz), high‐alpha (10–14 Hz), beta (14–30 Hz), and gamma (30–50 Hz) frequency ranges during eyes‐opened hyperoxic conditions. During eyes‐closed hyperoxia, increases in the delta (0.5–3.5 Hz) and theta (3.5–7 Hz) frequency range were apparent together with decreases in the beta range. Hyperoxia appeared to accentuate the decrease of low alpha and gamma ranges across the eyes‐opened and eyes‐closed conditions, suggesting that it modulated brain state itself. As decreased alpha during eyes‐opened conditions has been associated with increased attentional processing and selective attention, and increased delta and theta during eyes‐closed condition are typically associated with the initiation of sleep, our results suggest a state‐specific and perhaps opposing influence of short‐term hyperoxia.

show abstract

The impact of hyperoxia on brain activity: A resting-state and task-evoked electroencephalography (EEG) study

Cited by 20 publications

References 41 publications

Electrophysiological correlates of hyperoxia during resting-state EEG in awake human subjects

Electrophysiological correlates of hyperoxia during resting-state EEG in awake human subjects

The effect of sevoflurane and isoflurane anesthesia on single unit and local field potentials

Electrophysiological correlates of hyperoxia during resting‐state EEG in awake human subjects

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