The Impact of Hypertension on Patients with Acute Coronary Syndromes

Picariello, Claudio; Lazzeri, Chiara; Attanà, Paola; Chiostri, Marco; Gensini, Gian Franco; Valente, Serafina

doi:10.4061/2011/563657

Cited by 80 publications

(55 citation statements)

References 60 publications

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“…Notably, the great majority of patients with hypertension were found with STEMI followed by NSTEMI. In general, the prevalence of hypertension rises progressively with age in both men and women and ac as strong risk factor for ACS [23]. A previous study revealed a 63.4% prevalence of hypertension among ACS patients [24].…”

Section: Discussionmentioning

confidence: 99%

Risk Factors Associated with Acute Coronary Syndrome in Northern Saudi Arabia

2017

JCCR

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Objective: The aim of this study was to find out the common risk factors associated with Acute Coronary Syndrome (ACS) in Northern Kingdom of Saudi Arabia (KSA).Methodology: One hundred and fifty six patients with ACS were investigated in intensive care unit (ICU), at cardiac center in King Khalid Hospital, in northern KSA, city of Hail.Results: Risk factors for ACS including; Hypertension, Ischemic Heart Disease (IHD), Smoking, Diabetes Miletus (DM), and Dyslipidemia were found in 68.6%, 34.6%, 20.5%, 59% and 83.3% of the patients, respectively. Conclusion:The most common risk factors for ACS in northern KSA (Hail region) were dyslipidemia and hypertension. These favored the urgent need for intervention and control, which lower the burden of ACS.

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Section: Discussionmentioning

confidence: 99%

Risk Factors Associated with Acute Coronary Syndrome in Northern Saudi Arabia

2017

JCCR

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“…For example, in mice, aberrant D 3 receptor expression in heart and in peripheral vascular systems may increase intimal permeability, vascular remodeling, atherosclerosis formation, or the possibility of plaque rupture by interacting with renin, angiotensin II, insulin, endothelin, and cytokine vascular permeability factor/vascular endothelial growth factor. [33][34][35][36][37][38] Additionally, there are several blood coagulation pathways involving D 3 receptors systems, including the activation of platelet aggregation and the secretion of the procoagulant von Willebrand factor. 39,40 Hence, D 3 receptors blockade could also predispose the patient to the formation of acute thrombosis in stenotic coronary arteries, contributing to AMI.…”

Section: Discussionmentioning

confidence: 99%

Association Between Antipsychotic Use and Risk of Acute Myocardial Infarction

et al. 2014

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R ecent evidence suggests that psychiatric patients may be at increased risk for cardiovascular events. Large community studies report that people with mental illnesses have a 2-to 5-fold greater risk of coronary heart disease and a 2-to 3-fold greater risk of cardiac mortality than the general population. [1][2][3] This increased risk might be explained by risk factors commonly noted in these patients, including smoking, obesity, and unhealthy lifestyles. 4-6 Clinical Perspective on p 243The association of risk for acute myocardial infarction (AMI) with antipsychotic treatment remains unclear because earlier analyses have methodological issues (eg, residual confounding and limited statistical power and external validity). 3,[7][8][9][10][11] If the link exists, more attention might be paid to monitoring drug safety, especially because of current increased use of antipsychotics and the widening range of disorders for which they are being indicated. 12This study tapped a large nationwide population-based data set to investigate the association between antipsychotic treatment and risk of AMI in patients with mental disorders. A casecrossover design was used to eliminate known or unknown within-subject time-invariant confounders while examining the acute effects of various antipsychotics on subsequent AMI Background-Antipsychotic medications have been increasingly and more widely prescribed despite continued uncertainty about their association with the incidence of acute myocardial infarction (AMI

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“…Data on the prognostic role of a pre-existing hypertensive state in ACS patients are contradictory and come mostly from old trials and registries, before the era of thrombolysis. 1 In patients with acute myocardial infarction (AMI), the prevalence of history of HTN varies from 31 to 59%. 2,3 On the contrary, it is not clear whether previously known hypertensive patients have an increased rate of adverse outcomes after non-ST elevation AMI (NSTEMI).…”

Section: Introductionmentioning

confidence: 99%

Hypertension and acute coronary syndromes in Romania: data from the ISACS-TC registry

Dorobanțu

Tăutu

Fruntelată

et al. 2014

European Heart Journal Supplements

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There is little information on the incidence and prognostic significance of arterial hypertension (HTN) in acute coronary syndromes (ACSs), especially in the east European countries. We sought to investigate a registry of ACS patients in Romania, in order to better elucidate whether hypertensive patients are at higher risk of death and deserve a tailored approach for management and follow-up. The data of this study are a framework of the International Survey of Acute Coronary Syndromes in Transitional Countries (ISACS-TC) (ClinicalTrials.gov, NCT01218776). The present analysis focused on 2286 retrospective patients admitted to 23 hospitals in Romania with a diagnosis of ACS. Among 1450 hypertensive patients, 64.5% were admitted with a diagnosis of STelevation myocardial infarction (STEMI), while the remaining was admitted with a diagnosis of non-STEMI (NSTEMI). When compared with non-hypertensive patients, hypertensive patients were older (mean age 60.3 vs. 66.7 years, P , 0.001), were prevalently female (25.8% vs. 35.5%, P , 0.001), and had higher rates of cardiovascular risk factors as well as higher rates of prior myocardial infarction (11.2% vs. 18.3%, P , 0.001). Additionally, they had higher rates of prior stroke (4.2% vs. 11.7%, P , 0.001) and chronic heart failure (11.5% vs. 18.4%, P , 0.001). Despite this adverse clinical profile, hypertensive patients were less likely be to be admitted with Killip class ≥2 (23.1% vs. 26.6%, P , 0.001) but they were more likely to be discharged with NYHA class ≥III (10.6% vs. 7.1%, P , 0.006). There were significant higher rates of unadjusted in-hospital mortality among hypertensive older (.65 years) patients with both STEMI and NSTEMI. Hypertensive ACS patients in Romania represent a higher risk group, since they are more often discharged with NYHA class ≥ III, are older and have an adverse clinical profile. In the elderly, the outcomes of the hypertensive patients are worse than non-hypertensive patients.

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The Impact of Hypertension on Patients with Acute Coronary Syndromes

Cited by 80 publications

References 60 publications

Risk Factors Associated with Acute Coronary Syndrome in Northern Saudi Arabia

Risk Factors Associated with Acute Coronary Syndrome in Northern Saudi Arabia

Association Between Antipsychotic Use and Risk of Acute Myocardial Infarction

Hypertension and acute coronary syndromes in Romania: data from the ISACS-TC registry

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