The impact of hypoxia on extracellular vesicle secretome profile of cancer

Mortezaee, Keywan; Majidpoor, Jamal

doi:10.1007/s12032-023-01995-x

Cited by 13 publications

(5 citation statements)

References 75 publications

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“…These observations were consistent with the present data from expression microarray analysis, where PostNAC-O xenografts exhibited enhanced expression of EMT-and hypoxia-related genes. Our results can be interpreted in terms of rapid growth of PostNAC-O in vivo, causing substantial necrosis accompanied by upregulation of hypoxia-responsive genes, resulting in induction of EMT, as previous studies have demonstrated that EMT can be induced by hypoxia [27][28][29] . Interestingly, however, PostNAC-O showed upregulation of hypoxia-and EMT-related genes even under normoxic culture conditions without enhancement of proliferative activity.…”

Section: Discussionsupporting

confidence: 55%

“…To reveal the precise mechanisms underlying the upregulation of EMT-and hypoxiarelated genes in PostNAC-O, further studies are required. While upregulation of EMT-related genes could be attributed to upregulation of hypoxia-related genes [27][28][29] , it remains to be clari ed why hypoxia-related genes are upregulated in PostNAC-O relative to PreNAC-O even in normoxic culture. Further clari cation of the mechanism(s) underlying the induction of hypoxia-related genes in PostNAC-O would help to throw more light on the processes governing chemoresistance.…”

Section: Discussionmentioning

confidence: 99%

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Characterization of residual cancer by comparison of a pair of organoids established from a patient with ESCC before and after neoadjuvant chemotherapy

Fuchino,

Kurogi,

Tsukamoto

et al. 2023

Preprint

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Neoadjuvant chemotherapy (NAC) followed by surgery is a standard approach for management of locally advanced esophageal squamous cell carcinoma (ESCC). Patients who do not respond well to NAC have a poor prognosis. Despite extensive research, the mechanisms of chemoresistance in ESCC remain largely unknown. Here, we established paired tumor organoids – designated as PreNAC-O and PostNAC-O – from one ESCC patient before and after NAC, respectively. Although the two organoids did not exhibit significant differences in proliferation, morphology or drug sensitivity in vitro, the tumorigenicity of PostNAC-O in vivo was significantly higher than that of PreNAC-O. Xenografts from PreNAC-O tended to exhibit keratinization, while those from PostNAC-O displayed conspicuous necrotic areas. The tumorigenicity of PostNAC-O xenografts during the chemotherapy was comparable to that of PreNAC-O without treatment. Furthermore, the gene expression profiles of the xenografts suggested that expression of genes involved in the EMT and/or hypoxia response might be related to the tumorigenicity of PostNAC-O. Our data suggested that the tumorigenicity of residual cancer had been enhanced, outweighing the effects of chemotherapy, rather than being attributable to intrinsic chemoresistance. Further studies are required to clarify the extent to which residual cancers share a common mechanism similar to that revealed here.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Characterization of residual cancer by comparison of a pair of organoids established from a patient with ESCC before and after neoadjuvant chemotherapy

Fuchino,

Kurogi,

Tsukamoto

et al. 2023

Preprint

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“…Hypoxia is a hallmark of TME in solid cancers [ 202 ]. It not only promotes tumor growth, but also reduces the effectiveness of treatment.…”

Section: Nano-hbocs For Cancer Therapymentioning

confidence: 99%

Nanomaterial-related hemoglobin-based oxygen carriers, with emphasis on liposome and nano-capsules, for biomedical applications: current status and future perspectives

Zhu,

Wang,

Xiao

et al. 2024

J Nanobiotechnol

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Oxygen is necessary for life and plays a key pivotal in maintaining normal physiological functions and treat of diseases. Hemoglobin-based oxygen carriers (HBOCs) have been studied and developed as a replacement for red blood cells (RBCs) in oxygen transport due to their similar oxygen-carrying capacities. However, applications of HBOCs are hindered by vasoactivity, oxidative toxicity, and a relatively short circulatory half-life. With advancements in nanotechnology, Hb encapsulation, absorption, bioconjugation, entrapment, and attachment to nanomaterials have been used to prepare nanomaterial-related HBOCs to address these challenges and pend their application in several biomedical and therapeutic contexts. This review focuses on the progress of this class of nanomaterial-related HBOCs in the fields of hemorrhagic shock, ischemic stroke, cancer, and wound healing, and speculates on future research directions. The advancements in nanomaterial-related HBOCs are expected to lead significant breakthroughs in blood substitutes, enabling their widespread use in the treatment of clinical diseases. Graphical Abstract

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“…Hypoxia promotes the production and secretion of exosomes by tumor cells, which conversely facilitates the delivery of biological information, further enhancing hypoxia and promoting the functionality of hypoxia-inducible factors. 49 Patton et al . discovered that hypoxia enhances the release of smaller-sized exosomes by pancreatic cancer cells, thereby enabling the increased survival of these cancer cells.…”

Section: Preparation Strategies For Engineered Exosomesmentioning

confidence: 99%

A comprehensive review of engineered exosomes from the preparation strategy to therapeutic applications

Fan,

Zhang,

Liu

et al. 2024

Biomater. Sci.

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The impact of hypoxia on extracellular vesicle secretome profile of cancer

Cited by 13 publications

References 75 publications

Characterization of residual cancer by comparison of a pair of organoids established from a patient with ESCC before and after neoadjuvant chemotherapy

Characterization of residual cancer by comparison of a pair of organoids established from a patient with ESCC before and after neoadjuvant chemotherapy

Nanomaterial-related hemoglobin-based oxygen carriers, with emphasis on liposome and nano-capsules, for biomedical applications: current status and future perspectives

A comprehensive review of engineered exosomes from the preparation strategy to therapeutic applications

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