The Impact of Illness Perceptions on Depressive Symptoms Among Benign Prostatic Hyperplasia Patients with Lower Urinary Tract Symptom

Yang, Linlin; Chen, Xin; Liu, Zhiqi; Sun, Wei; Yu, Dexin; Tang, Honglei; Zhang, Zhiqiang

doi:10.2147/ijgm.s342512

Cited by 3 publications

(2 citation statements)

References 49 publications

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“…40,51,53,54,58-62,66,67,69,70,76,78-80,84,86,90,92-98, 101,102,104,106-116,118-122,126-129,131-136 A clear temporal relationship is beginning to be investigated that shows some evidence of depression predating urologic symptoms. 56,61,67,78,80,94,97,98,102,104,108,[111][112][113][114]116,118,127,129 I would like to highlight several studies that have data to suggest that depression can independently cause LUTS. 51,62,66,79,90,97,106,108,115,116,121,122,127,132,134 Of these studies, I would like to specifically highlight the association between BPH and suicide in South Korea and the mouse model of psychological stress inducing bladder overactivity in female mice.…”

Section: Introductionmentioning

confidence: 99%

“…56,61,67,78,80,94,97,98,102,104,108,[111][112][113][114]116,118,127,129 I would like to highlight several studies that have data to suggest that depression can independently cause LUTS. 51,62,66,79,90,97,106,108,115,116,121,122,127,132,134 Of these studies, I would like to specifically highlight the association between BPH and suicide in South Korea and the mouse model of psychological stress inducing bladder overactivity in female mice. 115,132 The BPH and suicide study was a retrospective look at men who had committed suicide over a 9-year period evaluating 193,785 Korean adults.…”

Section: Introductionmentioning

confidence: 99%

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Lower Urinary Tract Symptoms in Depression: A Review

Anderson,

Aucoin,

Toups

et al. 2023

Health Psychology Research

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Lower Urinary Tract Symptoms (LUTS) are frequently present in the general population as patients age with approximately a third of individuals experiencing LUTS during their lifetime. LUTS can be further defined as having any of the following symptoms: urinary hesitancy, straining, nocturia, increased urination frequency, and dysuria. LUTS has the potential for patients to contribute their symptoms to what can normally occur as we age. This can lead to a decrease in patients seeking care and could negatively impact patients’ health-related quality of life (HRQL). In conjunction with LUTS, we obtained from our analysis that LUTS and depression are closely related and worsening depressive symptoms may increase the severity of LUTS. We also discerned three categories of factors that can yield major depression namely adversity, internalizing, and externalizing factors. Within these categories, trauma, social support, genetic factors, and minimal education appeared to increase the risk of depression in patients. With the recent increase in mental health awareness and more access to mental health care amid the COVID-19 Pandemic, further screening, and collaboration between providers to treat both urological and psychiatric symptoms could improve patient outcomes. It is important for providers to have an increased understanding of the mental and physical impact both LUTS and depression can have on patients’ wellbeing. This has the potential to help patients be more open about their symptoms with the aim of better addressing LUTS and depression to positively impact their HRQL.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lower Urinary Tract Symptoms in Depression: A Review

Anderson,

Aucoin,

Toups

et al. 2023

Health Psychology Research

View full text Add to dashboard Cite

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Investigating the causal relationship between major depressive disorder and benign prostatic hyperplasia: a bidirectional Mendelian randomisation study

Zheng,

Xiao,

Cheng

et al. 2024

Psychogeriatrics

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BackgroundEvidence from various cohort studies indicate a potential association between depressive disorder and benign prostatic hyperplasia (BPH), yet findings are inconsistent. This study employs bidirectional two‐sample Mendelian randomisation (MR) analysis to explore the causal relationship between BPH and major depressive disorder (MDD).MethodsGenetic variants strongly associated with MDD were extracted as instrumental variables conducted by the Psychiatric Genomics Consortium (PGC). Two sets of genetic variants associated with BPH were extracted from the recent FinnGen and Medical Research Council‐Integrative Epidemiology Unit Consortium of BPH as the discovery and replication stages, respectively. Bidirectional MR analysis employed methods such as inverse variance weighted, MR‐Egger, weighted median, maximum likelihood, and weighted mode. The inverse variance weighted method was primarily used to evaluate the causal relationship.ResultsMR analysis in both the discovery and replication stages showed a significant causal relationship between MDD and the risk of BPH (discovery stages, odds ratio (OR) = 1.1146, 95% CI 1.0058–1.2353, P = 0.03852; replication stage, OR: 1.0042, 95% CI 1.0019–1.0065, P = 0.0004). No causal relationship was found between BPH and MDD risk in the reverse MR analysis.ConclusionsOur findings highlight a significant association between MDD and an increased risk of BPH development. Further investigation is needed to elucidate the underlying mechanisms linking depression and BPH.

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Longitudinal association between the dynamic nature of depression with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH)

Xie,

Liu,

et al. 2024

BMC Public Health

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Background Depression is associated with an increased risk of lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH). Whether the dynamic nature of depression affects the incidence of LUTS/BPH remains unknown. A four-year cohort study based on the China Health and Retirement Longitudinal Study (CHARLS) was conducted to assess their association. Methods This study included 3433 Chinese men from the CHARLS 2011, representative of > 95 million individuals. All eligible individuals underwent three assessments of LUTS/BPH and depression in 2011, 2013 and 2015. The dynamic nature of depression was classified as acute depression with remission, acute depression with recurrence, or chronic major depression. Weighted, generalized additive analyses with three binomial models were used to investigate the relationship between LUTS/BPH and the dynamic nature of depression. Results During the four-year follow-up, 11.5% (95% confidence interval [95% CI] = 9.5-13.3%) of Chinese men were diagnosed with newly incident LUTS/BPH. Meanwhile, there were 60.6% (95% CI = 58.5-62.7%) of the individuals without depression and 8.9% (95% CI = 7.9-10%) of the individuals with chronic major depression. A total of 25.1% (95% CI = 23.4-26.9%) and 5.4% (95% CI = 4.6-6.3%) of the individuals were categorized as acute depression with remission and recurrence. After weighted, adjusted all included confounding risk factors, chronic major depression (RR = 1.63, 95% CI = 1.14–2.33, P < 0.01) but not acute depression with remission (RR = 1.2, 95% CI = 0.92–1.56, P = 0.18) and recurrence (RR = 1.32, 95% CI = 0.82–2.10, P = 0.26) significantly increased the incidence of LUTS/BPH compared with no depression. The subgroup analysis showed that the above relationships appeared to be evident among Chinese men < 60 years. Conclusions Our results suggest that the dynamic nature of depression has a different effect on the incidence of LUTS/BPH. The monitoring and treatment of depression are important in preventing LUTS/BPH.

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The Impact of Illness Perceptions on Depressive Symptoms Among Benign Prostatic Hyperplasia Patients with Lower Urinary Tract Symptom

Cited by 3 publications

References 49 publications

Lower Urinary Tract Symptoms in Depression: A Review

Lower Urinary Tract Symptoms in Depression: A Review

Investigating the causal relationship between major depressive disorder and benign prostatic hyperplasia: a bidirectional Mendelian randomisation study

Longitudinal association between the dynamic nature of depression with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH)

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