The Impact of Imaging-Diagnosed Sarcopenia on Long-term Prognosis After Curative Resection for Hepatocellular Carcinoma: A Systematic Review and Meta-analysis

Kong, Qingyan; Gao, Qianqian; Li, Wenjie; Chen, Zheyu

doi:10.1016/j.acra.2023.11.040

Cited by 3 publications

(2 citation statements)

References 71 publications

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“…They analyzed 30 studies, with a total of 7352 HCC patients (2695 in the sarcopenia group and 4657 in the non-sarcopenia group) who had undergone curative surgical resection. The meta-analysis performed on 28 out of the 30 studies indicated that the patients with sarcopenia had a significantly lower overall survival (HR = 2.20; 95% CI, 1.88-2.58; p < 0.01) [58]. These findings confirm the considerable importance of identifying and correcting sarcopenia in HCC patients who are candidates for surgery.…”

Section: Sarcopenia In Hcc Patientsmentioning

confidence: 55%

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Ultrasound Evaluation of Sarcopenia in Patients with Hepatocellular Carcinoma: A Faster and Easier Way to Detect Patients at Risk

Esposto,

Borriello,

Galasso

et al. 2024

Diagnostics

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The condition of sarcopenia, defined as a progressive loss of musculoskeletal mass and muscular strength, is very common in patients with hepatocellular carcinoma (HCC) and presents a remarkable association with its prognosis. Thus, the early identification of sarcopenic patients represents one of the potential new approaches in the global assessment of HCC, and there is increasing interest regarding the potential therapeutic implications of this condition. The gold standard for the quantification of muscle mass is magnetic resonance imaging (MRI) or computed tomography (CT), but these techniques are not always feasible because of the high-cost equipment needed. A new possibility in sarcopenia identification could be muscle ultrasound examination. The measurement of specific parameters such as the muscle thickness, muscular fascicles length or pennation angle has shown a good correlation with CT or MRI values and a good diagnostic accuracy in the detection of sarcopenia. Recently, these results were also confirmed specifically in patients with chronic liver disease. This review summarizes the role of imaging for the diagnosis of sarcopenia in patients with HCC, focusing on the advantages and disadvantages of the diagnostic techniques currently validated for this aim and the future perspectives for the identification of this condition.

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Section: Sarcopenia In Hcc Patientsmentioning

confidence: 55%

“…The overall influence of sarcopenia on the post-operative prognosis of HCC was recently summarized by Kong and colleagues [58]. They analyzed 30 studies, with a total of 7352 HCC patients (2695 in the sarcopenia group and 4657 in the non-sarcopenia group) who had undergone curative surgical resection.…”

Section: Sarcopenia In Hcc Patientsmentioning

confidence: 99%

Ultrasound Evaluation of Sarcopenia in Patients with Hepatocellular Carcinoma: A Faster and Easier Way to Detect Patients at Risk

Esposto,

Borriello,

Galasso

et al. 2024

Diagnostics

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The Missing Link: Sarcopenia’s Contribution to Long-term HCC Prognosis

Bahsoun,

Hussain

2024

Academic Radiology

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The Effects of Sarcopenia on Overall Survival and Postoperative Complications of Patients Undergoing Hepatic Resection for Primary or Metastatic Liver Cancer: A Systematic Review and Meta-Analysis

Giakoustidis,

Papakonstantinou,

Chatzikomnitsa

et al. 2024

JCM

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Background: Colorectal cancer is the third most common cancer worldwide, and 20–30% of patients will develop liver metastases (CRLM) during their lifetime. Hepatocellular carcinoma (HCC) is also one of the most common cancers worldwide with increasing incidence. Hepatic resection represents the most effective treatment approach for both CRLM and HCC. Recently, sarcopenia has gained popularity as a prognostic index in order to assess the perioperative risk of hepatectomies. The aim of this study is to assess the effects of sarcopenia on the overall survival (OS), complication rates and mortality of patients undergoing liver resections for HCC or CRLM. Methods: A systematic literature search was performed for studies including patients undergoing hepatectomy for HCC or CRLM, and a meta-analysis of the data was performed. Results: Sarcopenic patients had a significantly lower 5-year OS compared to non-sarcopenic patients (43.8% vs. 63.6%, respectively; p < 0.01) and a significantly higher complication rate (35.4% vs. 23.1%, respectively; p = 0.002). Finally, no statistical correlation was found in mortality between sarcopenic and non-sarcopenic patients (p > 0.1). Conclusions: Sarcopenia was significantly associated with decreased 5-year OS and increased morbidity, but no difference was found with regard to postoperative mortality.

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The Impact of Imaging-Diagnosed Sarcopenia on Long-term Prognosis After Curative Resection for Hepatocellular Carcinoma: A Systematic Review and Meta-analysis

Cited by 3 publications

References 71 publications

Ultrasound Evaluation of Sarcopenia in Patients with Hepatocellular Carcinoma: A Faster and Easier Way to Detect Patients at Risk

Ultrasound Evaluation of Sarcopenia in Patients with Hepatocellular Carcinoma: A Faster and Easier Way to Detect Patients at Risk

The Missing Link: Sarcopenia’s Contribution to Long-term HCC Prognosis

The Effects of Sarcopenia on Overall Survival and Postoperative Complications of Patients Undergoing Hepatic Resection for Primary or Metastatic Liver Cancer: A Systematic Review and Meta-Analysis

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