The Impact of Immunostimulating Nutrition on Infectious Complications After Upper Gastrointestinal Surgery

Kłęk, Stanisław; Kulig, Jan; Sierżęga, Marek; Szybiński, P.; Szczepanek, Kinga; Kubisz, Aldona; Kowalczyk, Tomasz; Gach, Tomasz; Pach, Radosław; Szczepanik, Antoni M.

doi:10.1097/sla.0b013e318180a3c1

Cited by 94 publications

(87 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, various flaws in the design of these studies have been noted [72]. Studies finding no benefit to immunoenhanced nutrition have also been reported [73][74][75]. Further research will be required to determine if immuno-enhanced formulas improve esophagectomy outcomes.…”

Section: Immuno-enhanced Nutritionmentioning

confidence: 88%

Nutritional management during neoadjuvant therapy for esophageal cancer

Bower

Martin

2009

Journal of Surgical Oncology

View full text Add to dashboard Cite

Patients undergoing neoadjuvant therapy for esophageal cancer are at a high risk for malnutrition due to the effects of chemoradiation, dysphagia, and malignancy induced cachexia. Preparation for esophagectomy requires careful assessment of nutritional risk and adequate supplementation as indicated. Supplementation via the enteral route is preferred to the parenteral route but requires feeding tube placement. Endoscopically placed silicone stents have also shown promise as a means to alleviate malnutrition and avoid invasive feeding tubes.

show abstract

Section: Immuno-enhanced Nutritionmentioning

confidence: 88%

Nutritional management during neoadjuvant therapy for esophageal cancer

Bower

Martin

2009

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

“…The role and the effectiveness of immunonutrition in patients undergoing upper GI surgery have been studied and debated extensively in the literature [47][48][49][50][51][52][53][54][55][56]. According to a meta-analysis of 11 randomized controlled clinical trials [56] of enteral nutrition with an immuneenhancing formula that included 1009 patients, nutritional support supplemented with key nutrients (arginine, glutamine, branched-chain amino acids, nucleotides, and omega-3 fatty acids) significantly reduced the risk of developing infectious complications and reduced the overall hospital stay in critically ill patients and in patients with GI cancer.…”

Section: Immunonutrition In Gastrointestinal (Gi) Surgerymentioning

confidence: 99%

Biology-based nutritional support of critically ill and injured patients

Dogjani¹,

Zatriqi

Uranues

et al. 2011

Eur Surg

View full text Add to dashboard Cite

“…13,[21][22][23][24][25][26][27][28][29] In the present study, we enrolled all patients at nutritional risk who were identified by using the NRS, and no restriction on the type of operation was made, as this patient group is likely to benefit most from nutritional interventions. [6][7][8] So far, no randomized trial on IN has used the NRS before.…”

Section: Discussionmentioning

confidence: 99%

Preoperative immunonutrition in patients at nutritional risk: results of a double-blinded randomized clinical trial

et al. 2012

View full text Add to dashboard Cite

BACKGROUND/OBJECTIVES:To evaluate the impact of preoperative immunonutrition (IN) on postoperative morbidity in patients at risk of malnutrition undergoing major gastrointestinal (GI) surgery. SUBJECTS/METHODS: The combination of malnutrition and major GI surgery entails high morbidity. The Nutritional Risk Score (NRS) reliably identifies patients who need preoperative nutrition; the optimal nutritional formula for these patients still needs to be defined. In all, 152 patients with a NRSX3 and undergoing elective major GI surgery were randomized between IN or isocaloricisonitrogenous nutrition (ICN) given for 5 days preoperatively. Patients and caregivers were blinded for the allocated intervention. Thirty days complication rate was the primary endpoint. Infections, length of hospital stay and compliance were considered as secondary outcomes. RESULTS: Overall, 145 patients were available for analysis; the 73 patients in the IN group matched well with the 72 ICN patients with regards to patient's and surgical characteristics. In all, 39 IN and 33 ICN patients experienced a total of 48 and 50 postoperative complications, respectively (P ¼ 0.723). Both groups did not differ significantly concerning infectious (13 vs 9) complications. Independent risk factors for overall complications were malignant disease (odds ratio (OR) ¼ 4.304; confidence interval (CI) 1.317-14.002) and operative time (OR ¼ 1.004; CI 1.000-1.008). CONCLUSION: In patients at nutritional risk, complications, infections and hospital stay after major GI surgery were comparable regardless of preoperative supplementation with IN or ICN.

show abstract

The Impact of Immunostimulating Nutrition on Infectious Complications After Upper Gastrointestinal Surgery

Cited by 94 publications

References 46 publications

Nutritional management during neoadjuvant therapy for esophageal cancer

Nutritional management during neoadjuvant therapy for esophageal cancer

Biology-based nutritional support of critically ill and injured patients

Preoperative immunonutrition in patients at nutritional risk: results of a double-blinded randomized clinical trial

Contact Info

Product

Resources

About