The impact of in vitro fertilization on health of the children: an update

Fortunato, Adriana; Tosti, Elisabetta

doi:10.1016/j.ejogrb.2010.10.012

Cited by 34 publications

(34 citation statements)

References 48 publications

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“…The ICSI process also introduces additional sperm components into the egg cytoplasm. Despite documented efficiency and success in infertility treatment using ART, there is increasing evidence of congenital malformations and chromosome aberrations in children born after ICSI and IVF [14,15,20,29]. A study that assessed the risk of nuclear spindle damage following ICSI suggests that this technique might interfere with regular chromosome segregation at the second meiotic division of the oocytes [27].…”

Section: Introductionmentioning

confidence: 99%

Effect of sperm entry on blastocyst development after in vitro fertilization and intracytoplasmic sperm injection — mouse model

Piotrowska-Nitsche

Chan

2012

J Assist Reprod Genet

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Purpose To investigate whether in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), influence the embryo's development and its quality using the mouse as a model. Methods Assisted fertilization was performed using ICSI and IVF. Fluorescent beads were adhered to the fertilization cone or place of previous sperm injection in the natural mated (NM), IVF and ICSI embryos, respectively. Embryo examination was carried out at the two-cell and blastocyst stage to determine the position of fluorescent bead. Protein expression was detected by fluorescence immunocytochemical staining and confocal microscopic imaging of blastocysts. Results IVF and ICSI embryos developed at rates comparable to NM group. Embryos show similar expression patterns of two transcription factors, Oct4 and Cdx2. The most preferred place for spermatozoa attachment was the equatorial site of the egg, whether fertilization occurred in vitro or under natural conditions. We also link the sperm entry position (SEP) to embryo morphology and the number of cells at the blastocyst stage, with no influence of the method of fertilization. Conclusions IVF and ICSI, do not compromise in vitro preimplantation development. Additional data, related to sperm entry, could offer further criteria to predict embryos that will implant successfully. Based on embryo morphology, developmental rate and protein expression level of key transcription factors, our results support the view that ART techniques, such as IVF and ICSI, do not perturb embryonic development or quality.

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Section: Introductionmentioning

confidence: 99%

Effect of sperm entry on blastocyst development after in vitro fertilization and intracytoplasmic sperm injection — mouse model

Piotrowska-Nitsche

Chan

2012

J Assist Reprod Genet

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“…On the other hand, in contrast to what is described in the literature, we did not find any relationship between the type of pregnancy (ART or natural) and the rate of infant complications. (18…”

Section: Discussionmentioning

confidence: 99%

Outcomes in women receiving low-molecular-weight heparin during pregnancy

Sancho

Khalid

Christos

2012

Blood Coagulation &Amp; Fibrinolysis

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Objective To assess the rate and type of maternal and infant complications among pregnant women receiving low-molecular-weight heparin (LMWH). Study Design Retrospective study of pregnant women on LMWH referred to two university hematology clinics from January 2001 to December 2010. We recorded the number of pregnancies, indication, dose and dose adjustments for LMWH, pregnancy outcomes (live births, maternal and infant complications) and side effects of LMWH. Results There were 89 pregnancies in 76 women. The most common indication for LMWH was a history of adverse outcome of pregnancy associated with thrombophilia. LMWH was adjusted in 75% and 45% of pregnancies in women on therapeutic and prophylactic doses, respectively. Live birth rate was 97%. There were 25 maternal and 11 infant complications. Side effects were minimal and included decreased bone mineral density and bleeding. Conclusion LMWH use among pregnant women is associated with successful pregnancy outcomes. While side effects were minimal, maternal and infant complications occurred in 28% and 12% of cases, respectively.

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“…Si bien existen desde 1995 dudas sobre la seguridad de los procedimientos, hasta muy recientemente han obviado tan grave asunto con la falacia de que no está clara la causa en cuanto que no se conoce -se decía-qué proporción del daño se debe a la situación de los gametos de los progenitores y qué proporción se debe a las técnicas en sí mismas. Resumiendo los numerosos estudios: a) La inseminación intrauterina conlleva tantos riesgos para la descendencia como la fecundación in vitro o la inyección de un espermatozoide al óvulo (Sagot et al, 2012); b) Esta última es más perjudicial que la convencional; c) El riesgo de nacer con algún tipo de defecto es mayor que cuando son engendrados (Davies, et al, 2012;Pandey et al, 2012); d) Se generan síndromes raros (Fortunato & Tosti, 2011) y alteraciones que aparecen a largo plazo, causadas por la exposición del embrión en los primeros días de vida a un entorno adverso (Scherrer, et al, 2012).…”

Section: Ineficiencia De La Tecnologíaunclassified

La ética y la bioética de la programación de la humanidad

Moratalla

2014

Rev. Lasallista Investig.

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The impact of in vitro fertilization on health of the children: an update

Cited by 34 publications

References 48 publications

Effect of sperm entry on blastocyst development after in vitro fertilization and intracytoplasmic sperm injection — mouse model

Effect of sperm entry on blastocyst development after in vitro fertilization and intracytoplasmic sperm injection — mouse model

Outcomes in women receiving low-molecular-weight heparin during pregnancy

La ética y la bioética de la programación de la humanidad

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