New cases of the coronavirus disease and its fatal consequences continue to be recorded even now, almost three years after the first detected case. The problem of the COVID-19 spread worries the world community because the virus affects the social, economic, environmental, political, and other spheres of every person’s life. The pandemic reality has brought a massive range of changes to the everyday life of both Ukrainians and representatives of other nations. The purpose of this study is to identify general trends in the dynamics of indicators of the COVID-19 rate and transformation vectors of critical indicators in the healthcare system. The article reviews modern publications on COVID-19 and healthcare. This study presents the dynamics of changes in Ukraine’s health, life, and mortality indicators concerning the COVID-19 pandemic. The urgency of this problem is due to the further detection of new cases of illness and death from COVID-19 in Ukraine. The issue of its spread requires further new research. Analytical and graphical methods were used to predict structural changes in morbidity, mortality, and factors affecting it. The data forecast period covers the years 2021-2023. The accuracy of forecasts is assessed by the MAPE and RMSPE quality criteria. The obtained results showed that the number of cases of illness and death from COVID-19 in Ukraine would decrease over the forecast period due to the increase in the birth rate and vital activity in the pandemic conditions. In the current realities of the world, human resources are of integral importance both for Ukraine with its current situation and for the world in general. The results of further research will play an essential role in the timely detection of new cases of coronavirus disease and the prevention of fatal consequences in the future. For the political structure, this study will help to predict possible changes in the behaviour of coronavirus spread for the following months or years. Also, it will introduce the necessary quarantine restrictions promptly. A comprehensive in-depth study of this problem in science and medicine can help determine new factors of behaviour in everyday human life, which affects the virus spread speed. Even though the attention of Ukrainians has shifted from the problem of morbidity and mortality from COVID-19 to the war beginning, this virus still poses a threat to our state and humanity in general.